Search Results - "Al Azzam, Wasfi"

Comparability of protein therapeutics: quantitative comparison of second-derivative amide I infrared spectra by D'antonio, Jennifer, Murphy, Brian M, Manning, Mark Cornell, Al-Azzam, Wasfi A

“…Comparability determination for protein therapeutics requires an assessment of their higher order structure, usually by using spectroscopic methods. One of the…”
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Characterization of protein higher order structure using vibrational circular dichroism spectroscopy by Nagarkar, Radhika P, Murphy, Brian M, Yu, Xiaotong, Manning, Mark Cornell, Al-Azzam, Wasfi A

“…Better understanding of protein higher order structures (HOS) is of major interest to researchers in the field of biotechnology and biopharmaceutics…”
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Recent trends in stabilizing protein structure upon encapsulation and release from bioerodible polymers by Pérez, Caroline, Castellanos, Ingrid J., Costantino, Henry R., Al-Azzam, Wasfi, Griebenow, Kai

“…Sustained release of pharmaceutical proteins from biocompatible polymers offers new opportunities in the treatment and prevention of disease. The manufacturing…”
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Comparability of higher order structure in proteins: chemometric analysis of second-derivative amide I Fourier transform infrared spectra by Stockdale, Gregory, Murphy, Brian M, D'Antonio, Jennifer, Manning, Mark Cornell, Al-Azzam, Wasfi

“…Comparing higher order structure (HOS) in therapeutic proteins is a significant challenge. Previously, we showed that changes in solution conditions produced…”
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Pharmacodynamic evaluation and safety assessment of treatment with antibodies to serum amyloid P component in patients with cardiac amyloidosis: an open-label Phase 2 study and an adjunctive immuno-PET imaging study by Wechalekar, Ashutosh, Antoni, Gunnar, Al Azzam, Wasfi, Bergström, Mats, Biswas, Swethajit, Chen, Chao, Cheriyan, Joseph, Cleveland, Matthew, Cookson, Louise, Galette, Paul, Janiczek, Robert L, Kwong, Raymond Y, Lukas, Mary Ann, Millns, Helen, Richards, Duncan, Schneider, Ian, Solomon, Scott D, Sörensen, Jens, Storey, James, Thompson, Douglas, van Dongen, Guus, Vugts, Danielle J, Wall, Anders, Wikström, Gerhard, Falk, Rodney H

“…In a Phase I study treatment with the serum amyloid P component (SAP) depleter miridesap followed by monoclonal antibody to SAP (dezamizumab) showed removal of…”
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Use of the amide II infrared band of proteins for secondary structure determination and comparability of higher order structure by Murphy, Brian M, D'Antonio, Jennifer, Manning, Mark C, Al-Azzam, Wasfi

“…Demonstrating comparability of secondary structure composition as part of higher order structure (HOS) in therapeutic proteins is a significant challenge…”
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Engineering of protein thermodynamic, kinetic, and colloidal stability: Chemical Glycosylation with monofunctionally activated glycans by Solá, Ricardo J., Al-Azzam, Wasfi, Griebenow, Kai

“…In this work we establish the relationship between chemical glycosylation and protein thermodynamic, kinetic, and colloidal stability. While there have been…”
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The biodistribution and clearance of AlbudAb, a novel biopharmaceutical medicine platform, assessed via PET imaging in humans by Thorneloe, Kevin S., Sepp, Armin, Zhang, Sean, Galinanes-Garcia, Laura, Galette, Paul, Al-Azzam, Wasfi, Vugts, Danielle J., van Dongen, Guus, Elsinga, Phillip, Wiegers, Johan, Glaudemans, Andor W. J. M., Vincent, Veena, Renaux, Jessica, Szapacs, Matt, Birchler, Mary, Cleveland, Matthew, Bergstrom, Mats, Davies, Marie

“…Conjugation or fusion to AlbudAbs™ (albumin-binding domain antibodies) is a novel approach to extend the half-life and alter the tissue distribution of…”
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Effect of the covalent modification with poly(ethylene glycol) on alpha-chymotrypsin stability upon encapsulation in poly(lactic-co-glycolic) microspheres by Castellanos, Ingrid J, Al-Azzam, Wasfi, Griebenow, Kai

“…The effectiveness of the covalent modification of alpha-chymotrypsin with methoxy poly(ethylene glycol) (PEG) to afford its stabilization during encapsulation…”
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On the relationship between the activity and structure of PEG-α-chymotrypsin conjugates in organic solvents by Castillo, Betzaida, Méndez, Jessica, Al-Azzam, Wasfi, Barletta, Gabriel, Griebenow, Kai

“…Enzymes are attractive catalysts for the production of optically active compounds in organic solvents. However, their often low catalytic activity in such…”
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Effect of the covalent modification of horseradish peroxidase with poly(ethylene glycol) on the activity and stability upon encapsulation in polyester microspheres by Al-Azzam, Wasfi, Pastrana, Emil A, King, Brian, Méndez, Jessica, Griebenow, Kai

“…Encapsulation of proteins in polyester microspheres by coacervation methods frequently causes protein inactivation and aggregation. Furthermore, an…”
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An Industry Perspective on Forced Degradation Studies of Biopharmaceuticals: Survey Outcome and Recommendations by Halley, Jennifer, Chou, Yite Robert, Cicchino, Crystal, Huang, Min, Sharma, Vikas, Tan, Niclas Chiang, Thakkar, Santosh, Zhou, Liqiang Lisa, Al-Azzam, Wasfi, Cornen, Stephane, Gauden, Magdalena, Gu, Zhenyu, Kar, Sambit, Lazar, Alexandru C, Mehndiratta, Promod, Smith, John, Sosic, Zoran, Weisbach, Paul, Stokes, Elaine S E

“…The BioPhorum Development Group is an industry-wide consortium enabling networking and sharing of common practices for the development of biopharmaceuticals…”
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Technical Decision Making With Higher Order Structure Data: Perspectives on Higher Order Structure Characterization From the Biopharmaceutical Industry by Weiss, 4th, William F, Gabrielson, John P, Al-Azzam, Wasfi, Chen, Guodong, Davis, Darryl L, Das, Tapan K, Hayes, David B, Houde, Damian, Singh, Satish K

“…Characterization of the higher order structure (HOS) of protein-based biopharmaceutical products is an important aspect of their development. Opinions vary…”
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Immuno-PET Imaging to Assess Target Engagement: Experience from 89 Zr-Anti-HER3 mAb (GSK2849330) in Patients with Solid Tumors by Menke-van der Houven van Oordt, C Willemien, McGeoch, Adam, Bergstrom, Mats, McSherry, Iain, Smith, Deborah A, Cleveland, Matthew, Al-Azzam, Wasfi, Chen, Liangfu, Verheul, Henk, Hoekstra, Otto S, Vugts, Danielle J, Freedman, Immanuel, Huisman, Marc, Matheny, Chris, van Dongen, Guus, Zhang, Sean

“…PET imaging with radiolabeled drugs provides information on tumor uptake and dose-dependent target interaction to support selection of an optimal dose for…”
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Immuno-PET Imaging to Assess Target Engagement: Experience from 89Zr-Anti-HER3 mAb (GSK2849330) in Patients with Solid Tumors by van Oordt, C Willemien Menke-van der Houven, McGeoch, Adam, Bergstrom, Mats, McSherry, Iain, Smith, Deborah A, Cleveland, Matthew, Al-Azzam, Wasfi, Chen, Liangfu, Verheul, Henk, Hoekstra, Otto S, Vugts, Danielle J, Freedman, Immanuel, Huisman, Marc, Matheny, Chris, van Dongen, Guus, Zhang, Sean

“…PET imaging with radiolabeled drugs provides information on tumor uptake and dose-dependent target interaction to support selection of an optimal dose for…”
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Structure of Poly(Ethylene Glycol)-Modified Horseradish Peroxidase in Organic Solvents: Infrared Amide I Spectral Changes upon Protein Dehydration Are Largely Caused by Protein Structural Changes and Not by Water Removal Per Se by Al-Azzam, Wasfi, Pastrana, Emil A., Ferrer, Yancy, Huang, Qing, Schweitzer-Stenner, Reinhard, Griebenow, Kai

“…Fourier transform infrared (FTIR) spectroscopy has emerged as a powerful tool to guide the development of stable lyophilized protein formulations by providing…”
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On the relationship between the activity and structure of PEG-[alpha]- chymotrypsin conjugates in organic solvents by Castillo, Betzaida, Mendez, Jessica, Al-Azzam, Wasfi, Barletta, Gabriel, Griebenow, Kai

“…Enzymes are attractive catalysts for the production of optically active compounds in organic solvents. However, their often low catalytic activity in such…”
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Structure of poly(ethylene glycol-modified horseradish peroxidase in organic solvents: Infrared amide I spectral changes upon protein dehydration are largely by Al-Azzam, Wasfi, Pastrana, Emil A, Ferrer, Yancy, Huang, Qing

“…Fourier transform infrared (FTIR) spectroscopy has emerged as a powerful tool to guide the development of stable lyophilized protein formulations by providing…”
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On the activity loss of hydrolases in organic solvents I. Rapid loss of activity of a variety of enzymes and formulations in a range of organic solvents by CASTILLO, Betzaida, PACHECO, Yamaris, AL-AZZAM, Wasfi, GRIEBENOW, Kai, DEVI, Manjula, FERRER, Amaris, BARLETTA, Gabriel

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Heme Structural Perturbation of PEG-Modified Horseradish Peroxidase C in Aromatic Organic Solvents Probed by Optical Absorption and Resonance Raman Dispersion Spectroscopy by Huang, Qing, Al-Azzam, Wasfi, Griebenow, Kai, Schweitzer-Stenner, Reinhard

“…The heme structure perturbation of poly(ethylene glycol)-modified horseradish peroxidase (HRP-PEG) dissolved in benzene and toluene has been probed by…”
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