Search Results - "Al‑Serwi, Rasha Hamed"
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Machine learning driven web-based app platform for the discovery of monoamine oxidase B inhibitors
Published in Scientific reports (28-02-2024)“…Monoamine oxidases (MAOs), specifically MAO-A and MAO-B, play important roles in the breakdown of monoamine neurotransmitters. Therefore, MAO inhibitors are…”
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Exploring the cytoprotective role of mesenchymal stem Cell-Derived exosomes in chronic liver Fibrosis: Insights into the Nrf2/Keap1/p62 signaling pathway
Published in International immunopharmacology (15-11-2024)“…Effect of MSCs-exo on targeted genes play critical roles in Nrf2/Keep1/P62 pathway in chronic liver inflammation. [Display omitted] •Pathology Reduction: The…”
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Polymeric ethosomal gel loaded with nimodipine: Optimisation, pharmacokinetic and histopathological analysis
Published in Saudi pharmaceutical journal (01-11-2022)“…This study was performed with the main objective of formulating and evaluating the potential of ethosomesl gel (Etho gel) to deliver nimodipine (NiM) for…”
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Extracellular Protease Production, Optimization, and Partial Purification from Bacillus nakamurai PL4 and its Applications
Published in Journal of King Saud University. Science (01-01-2023)“…[Display omitted] The major goal of the study was to isolate bacteria synthesizing protease enzyme from a soil sample taken in Dandeli, Karnataka, India…”
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Ameliorated Stomach Specific Floating Microspheres for Emerging Health Pathologies Using Polymeric Konjac Glucomannan-Based Domperidone
Published in BioMed research international (13-07-2022)“…The goal of this study was to use polymeric konjac glucomannan (KGM), Kollidon VA 64 (KVA64), and glutaraldehyde to ameliorate stomach specific floating…”
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Discovery of Some Heterocyclic Molecules as Bone Morphogenetic Protein 2 (BMP-2)-Inducible Kinase Inhibitors: Virtual Screening, ADME Properties, and Molecular Docking Simulations
Published in Molecules (Basel, Switzerland) (30-08-2022)“…Bone morphogenetic proteins (BMPs) are growth factors that have a vital role in the production of bone, cartilage, ligaments, and tendons. Tumors’ upregulation…”
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Astrocytes profiling in acute hepatic encephalopathy: Possible enrolling of glial fibrillary acidic protein, tumor necrosis factor-alpha, inwardly rectifying potassium channel (Kir 4.1) and aquaporin-4 in rat cerebral cortex
Published in Frontiers in cellular neuroscience (17-08-2022)“…Hepatic encephalopathy (HE) is a neurological disarray manifested as a sequel to chronic and acute liver failure (ALF). A potentially fatal consequence of ALF…”
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Impact of Some Natural and Artificial Sweeteners Consumption on Different Hormonal Levels and Inflammatory Cytokines in Male Rats: In Vivo and In Silico Studies
Published in ACS omega (16-07-2024)“…Substituting sugar with noncaloric sweeteners prevents overweight and diabetes development. They come in two types: artificial, like aspartame and sucralose,…”
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Potential of barley enriched yogurt to improve probiotic growth for the management of hypercholesterolemia
Published in International journal of food properties (22-09-2023)“…This study aimed to evaluate the effect of barley bran and flour-enriched yogurt against hypercholesterolemia in rats. Purposely, barley-enriched yogurts were…”
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Chalcones with N‐Methylpiperazine Moiety: Synthesis, Monoamine Oxidase Inhibition, Neuroprotective Effect and Computer Simulation Study
Published in ChemistrySelect (Weinheim) (12-04-2024)“…Eleven derivatives of chalcones (PZ1–PZ11) were synthesized by incorporating N‐methyl piperazine on the para position of the aromatic B ring of chalcones. The…”
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Targeting Some Key Metalloproteinases by Nano-Naringenin and Amphora coffeaeformis as a Novel Strategy for Treatment of Osteoarthritis in Rats
Published in Pharmaceuticals (Basel, Switzerland) (08-02-2023)“…Osteoarthritis (OA) represents the highest degenerative disorder. Because cartilage erosion is a common pathological alteration in OA, targeting some key…”
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Acute Effect of Whole-Body Vibration on Trunk Endurance and Balance in Obese Female Students: Randomized Controlled Trial
Published in Medicina (Kaunas, Lithuania) (01-08-2024)“…Compared to other subjects, obese people have inferior trunk muscle endurance and balance. A modern method of neuro-muscular training called whole body…”
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Exercise Augments the Effect of SGLT2 Inhibitor Dapagliflozin on Experimentally Induced Diabetic Cardiomyopathy, Possible Underlying Mechanisms
Published in Metabolites (11-07-2022)“…One of the most prevalent cardiovascular problems linked with type 2 diabetes mellitus (T2DM) is diabetic cardiomyopathy (DCM). DCM is associated with…”
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Proposed Mechanism for Emodin as Agent for Methicillin Resistant Staphylococcus Aureus: In Vitro Testing and In Silico Study
Published in Current issues in molecular biology (27-09-2022)“…In the search for a new anti-MRSA lead compound, emodin was identified as a good lead against methicillin-resistant Staphylococcus aureus (MRSA). Emodin serves…”
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Protective effect of nano vitamin D against fatty degeneration in submandibular and sublingual salivary glands: A histological and ultrastructural study
Published in Heliyon (01-04-2021)“…Poor nutritional habits and a low level of physical activity are associated with obesity, leading to increased caloric and fat intakes. A high-fat diet can…”
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Molecular Docking and Green Synthesis of Bioinorganic TiO2 Nanoparticles against E.coli and S.aureus
Published in Bioinorganic chemistry and applications (01-01-2022)“…This study used a simple solution evaporation approach to make a bioinorganic titanium dioxide (Bi-TiO2) photocatalyst for dye contaminant degradation. A…”
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Vitamin K2 (MK-7) Intercepts Keap-1/Nrf-2/HO-1 Pathway and Hinders Inflammatory/Apoptotic Signaling and Liver Aging in Naturally Aging Rat
Published in Antioxidants (30-10-2022)“…Aging is a naturally occurring physiological process with a deleterious impact on various body organs and humans’ well-being. The aging population is…”
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Hesperidin Attenuates Titanium Dioxide Nanoparticle-Induced Neurotoxicity in Rats by Regulating Nrf-2/TNF‑α Signaling Pathway, the Suppression of Oxidative Stress, and Inflammation
Published in ACS omega (10-10-2023)“…Background: Titanium dioxide nanoparticles (TiO2NPs) are widely utilized and consumed mainly as food additives. Oxidative stress is considered to be the basic…”
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Curcumin and vitamin C improve immunity of kidney via gene expression against diethyl nitrosamine induced nephrotoxicity in rats:In vivo and molecular docking studies
Published in Heliyon (01-03-2023)“…Kidney has a crucial role in immunity, so any toxicity occurs for the kidney will result in reduced immunity. The aim of this study is to improve the immune…”
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α-Lipoic Acid Protects against Cyclosporine A-Induced Hepatic Toxicity in Rats: Effect on Oxidative Stress, Inflammation, and Apoptosis
Published in Toxics (Basel) (01-08-2022)“…The clinical application of cyclosporine A (CsA) as an immunosuppressive agent is limited by its organ toxicity. We aimed to evaluate the effectiveness of…”
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