Search Results - "Al‑Balas, Qosay A."

Identification of the First "Two Digit Nano-molar" Inhibitors of the Human Glyoxalase-I Enzyme as Potential Anticancer Agents by Al-Balas, Qosay A, Al-Sha'er, Mahmoud A, Hassan, Mohammad A, Al Zou'bi, Esra'a

“…Glyoxalase-I (Glo-I) enzyme is recognized as an indispensable druggable target in cancer treatment. Its inhibition will lead to the accumulation of toxic…”
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Computational and experimental exploration of the structure–activity relationships of flavonoids as potent glyoxalase‐I inhibitors by Al‐Balas, Qosay A., Hassan, Mohammad A., Al‐Shar'i, Nizar A., El‐Elimat, Tamam, Almaaytah, Ammar M.

“…Hit, Lead & Candidate Discovery Glyoxalase‐I (Glo‐I) enzyme has emerged as a potential target for cancer treatment. Several classes of natural products…”
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The ethics of practicing defensive medicine in Jordan: a diagnostic study by Al-Balas, Qosay A E, Al-Balas, Hassan A E

“…Defensive medicine (DM) practice refers to the ordering or prescription of unnecessary treatments or tests while avoiding risky procedures for critically ill…”
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Computational fragment-based drug design of potential Glo-I inhibitors by Bibars, Roaa S, Al-Balas, Qosay A

“…In this study, a fragment-based drug design approach, particularly drug design, was implemented utilising three different crystal structures in order to…”
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Molecular Dynamics Simulations of Adenosine Receptors: Advances, Applications and Trends by Al-Shar'i, Nizar A, Al-Balas, Qosay A

“…Adenosine receptors (ARs) are transmembrane proteins that belong to the G protein-coupled receptors (GPCRs) superfamily and mediate the biological functions of…”
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Design, synthesis and biological evaluation of novel glyoxalase I inhibitors possessing diazenylbenzenesulfonamide moiety as potential anticancer agents by Al-Oudat, Buthina A., Jaradat, Hana'a M., Al‑Balas, Qosay A., Al-Shar'i, Nizar A., Bryant-Friedrich, Amanda, Bedi, Mel F.

“…[Display omitted] The enzyme glyoxalase-I (Glo-I) is an essential therapeutic target in cancer treatment. Significant efforts have been made to discover…”
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Recent Advances in Glyoxalase-I Inhibition by Al-Balas, Qosay A, Hassan, Mohammad A, Al-Shar'i, Nizar A, Al Jabal, Ghazi A, Almaaytah, Ammar M

“…Glyoxalase system is a ubiquitous system in human cells which has been examined thoroughly for its role in different disease conditions. It is composed of…”
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An Ethical Roadmap for Prioritizing Medical Resources Within Muslim Societies During the COVID-19 Pandemic by Al-Balas, Qosay A. E., Al-Delaimy, Wael K.

“…Profound ethical challenges have been generated by the emergence of the COVID-19 pandemic. The unprecedented plights that have arisen have led nations to…”
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Multi-Armed 1,2,3-Selenadiazole and 1,2,3-Thiadiazole Benzene Derivatives as Novel Glyoxalase-I Inhibitors by Al-Balas, Qosay A, Al-Smadi, Mousa L, Hassan, Mohammad A, Al Jabal, Ghazi A, Almaaytah, Ammar M, Alzoubi, Karem H

“…Glyoxalase-I (Glo-I) enzyme was established to be a valid target for anticancer drug design. It performs the essential detoxification step of harmful…”
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Ellagic acid: A potent glyoxalase-I inhibitor with a unique scaffold by Al-Shar’i, Nizar A., Al-Balas, Qosay A., Hassan, Mohammad A., El-Elimat, Tamam M., Aljabal, Ghazi A., Almaaytah, Ammar M.

“…The glyoxalase system, particularly glyoxalase-I (GLO-I), has been approved as a potential target for cancer treatment. In this study, a set of structurally…”
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The Ethics of Gene Editing from an Islamic Perspective: A Focus on the Recent Gene Editing of the Chinese Twins by Al-Balas, Qosay A. E., Dajani, Rana, Al-Delaimy, Wael K.

“…In light of the development of “CRISPR” technology, new promising advances in therapeutic and preventive approaches have become a reality. However, with it…”
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Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking by Audat, Suaad A, Al-Shar'i, Nizar A, Al-Oudat, Buthina A, Bryant-Friedrich, Amanda, Bedi, Mel F, Zayed, Aref L, Al-Balas, Qosay A

“…Leukotriene B4 (LTB4) is a potent, proinflammatory lipid mediator implicated in the pathologies of an array of inflammatory diseases and cancer. The…”
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Lead optimization and biological evaluation of diazenylbenzenesulfonamides inhibitors against glyoxalase-I enzyme as potential anticancer agents by Al-Oudat, Buthina A., Al-Shar'i, Nizar A., Al‑Balas, Qosay A., Audat, Suaad A., Alqudah, Mohammad A.Y., Hamzah, Ali H., Hallak, Ramez W., Bedi, Mel, Bryant-Friedrich, Amanda

“…[Display omitted] •Targeting the central zinc atom in the active site of glyoxalase I enzyme produces potent inhibitors.•Active inhibitors formed bidentate…”
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Virtual lead identification of farnesyltransferase inhibitors based on ligand and structure-based pharmacophore techniques by Al-Balas, Qosay A, Amawi, Haneen A, Hassan, Mohammad A, Qandil, Amjad M, Almaaytah, Ammar M, Mhaidat, Nizar M

“…Farnesyltransferase enzyme (FTase) is considered an essential enzyme in the Ras signaling pathway associated with cancer. Thus, designing inhibitors for this…”
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Methoxyphenylcipro induces antitumor activity in human cancer cells by Mhaidat, Nizar M., Qandil, Amjad M., Al-Balas, Qosay A., Hassan, Mohammad A., Jaradat, Saied A., Matalkah, Ahmad M., Thorne, Rick T.

“…To examine the antitumor activity of a new derivative of ciprofloxacin called methoxyphenylcipro (CMPP). Cell viability was assessed using the MTT assay and…”
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Traditional Islamic approach can enrich CRISPR twins debate by Al-Balas, Qosay A., Dajani, Rana, Al-Delaimy, Wael K.

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CRISPR twins: an Islamic perspective by Al-Balas, Qosay A, Dajani, Rana, Al-Delaimy, Wael K

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Synthesis, Antibacterial Evaluation and QSAR of α-Substituted-N₄-Acetamides of Ciprofloxacin and Norfloxacin by Qandil, Amjad M, Al-Zoubi, Lorca O, Al-Bakri, Amal G, Amawi, Haneen A, Al-Balas, Qosay A, Alkatheri, Abdulmalik M, Albekairy, Abdulkareem M

“…Twenty six α-substituted N₄-acetamide derivatives of ciprofloxacin (CIPRO) and norfloxacin (NOR) were synthesized and assayed for antibacterial activity…”
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Unraveling Potential Glyoxalase-I Inhibitors Utilizing Structure-Based Drug Design Techniques by Fetian, Mohammad H, Al-Balas, Qosay A

“…Glyoxalase system detoxifies methylglyoxal and other ketoaldehydes to produce innocuous metabolites that allow the cells to function normally. Its inhibition…”
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Combination of pharmacophore modeling and 3D-QSAR analysis of potential glyoxalase-I inhibitors as anticancer agents by Al-Sha'er, Mahmoud A., Al-Balas, Qosay A., Hassan, Mohammad A., Al Jabal, Ghazi A., Almaaytah, Ammar M.

“…Hydrogen bond map and Hydrophobic bond map of hit 27 (IC50 = 3.65 μM) docked in the binding pocket of Glyoxalase I (pdb: 3VW9, resolution =1.47 Å). [Display…”
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