Search Results - "Al‐Sarraj, S."

Invited Review: The spectrum of neuropathology in COVID‐19 by Al‐Sarraj, S., Troakes, C., Hanley, B., Osborn, M., Richardson, M. P., Hotopf, M., Bullmore, E., Everall, I. P.

“…There is increasing evidence that patients with Coronavirus disease 19 (COVID‐19) present with neurological and psychiatric symptoms. Anosmia, hypogeusia,…”
Get full text

RYR1 mutations are a common cause of congenital myopathies with central nuclei by Wilmshurst, J.M., Lillis, S., Zhou, H., Pillay, K., Henderson, H., Kress, W., Müller, C.R., Ndondo, A., Cloke, V., Cullup, T., Bertini, E., Boennemann, C., Straub, V., Quinlivan, R., Dowling, J.J., Al- Sarraj, S., Treves, S., Abbs, S., Manzur, A.Y., Sewry, C.A., Muntoni, F., Jungbluth, H.

“…Objective Centronuclear myopathy (CNM) is a rare congenital myopathy characterized by prominence of central nuclei on muscle biopsy. CNM has been associated…”
Get full text

British Neuropathological Society and International Society of Forensic Radiology and Imaging expert consensus statement for post mortem neurological imaging by Shelmerdine, S. C., Hutchinson, J. C., Al‐Sarraj, S., Cary, N., Dawson, T., Du Plessis, D., Ince, P. G., McLaughlin, S., Palm, L., Smith, C., Stoodley, N., Rijn, R., Arthurs, O. J., Jacques, T. S.

“…Aims To develop an expert consensus statement regarding appropriate clinical and forensic post mortem neurological imaging. Methods An expert panel of…”
Get full text

Unusual neuropathological features and increased brain aluminium in a resident of Camelford, UK by King, A., Troakes, C., Aizpurua, M., Mirza, A., Hodges, A., Al‐Sarraj, S., Exley, C.

Get full text

Cortical selective vulnerability in motor neuron disease: a morphometric study by Maekawa, S., Al‐Sarraj, S., Kibble, M., Landau, S., Parnavelas, J., Cotter, D., Everall, I., Leigh, P. N.

“…Neuroimaging and neuropsychological studies have revealed that the primary motor cortex (PMC) and the extramotor cortical areas are functionally abnormal in…”
Get full text

Transportin 1 colocalization with Fused in Sarcoma (FUS) inclusions is not characteristic for amyotrophic lateral sclerosis-FUS confirming disrupted nuclear import of mutant FUS and distinguishing it from frontotemporal lobar degeneration with FUS inclusions by Troakes, C., Hortobágyi, T., Vance, C., Al-Sarraj, S., Rogelj, B., Shaw, C. E.

“…C. Troakes, T. Hortobágyi, C. Vance, S. Al‐Sarraj, B. Rogelj and C. E. Shaw (2013) Neuropathology and Applied Neurobiology39, 553–561 Transportin 1…”
Get full text

Frontotemporal lobar degeneration and ubiquitin immunohistochemistry by Josephs, K. A., Holton, J. L., Rossor, M. N., Godbolt, A. K., Ozawa, T., Strand, K., Khan, N., Al-Sarraj, S., Revesz, T.

“…We set out to determine the frequency of the different pathologies underlying frontotemporal degeneration (FTD) in our brain bank series, by reviewing all…”
Get full text

Corticobasal syndrome associated with a novel 1048_1049insG progranulin mutation by Rohrer, J D, Beck, J, Warren, J D, King, A, Sarraj, S Al, Holton, J, Revesz, T, Collinge, J, Mead, S

“…[...]patients have also been described with a corticobasal syndrome (CBS), extending the pathological associations of this disorder into the TDP-43…”
Get full text

Neuropathology of the hippocampus in FTLD-Tau with Pick bodies: a study of the BrainNet Europe Consortium by Kovacs, G. G., Rozemuller, A. J. M., van Swieten, J. C., Gelpi, E., Majtenyi, K., Al-Sarraj, S., Troakes, C., Bódi, I., King, A., Hortobágyi, T., Esiri, M. M., Ansorge, O., Giaccone, G., Ferrer, I., Arzberger, T., Bogdanovic, N., Nilsson, T., Leisser, I., Alafuzoff, I., Ironside, J. W., Kretzschmar, H., Budka, H.

“…G. G. Kovacs, A. J. M. Rozemuller, J. C. van Swieten, E. Gelpi, K. Majtenyi, S. Al‐Sarraj, C. Troakes, I. Bódi, A. King, T. Hortobágyi, M. M. Esiri, O…”
Get full text

Traumatic axonal damage in the brain can be detected using β-APP immunohistochemistry within 35 min after head injury to human adults by Hortobágyi, T., Wise, S., Hunt, N., Cary, N., Djurovic, V., Fegan-Earl, A., Shorrock, K., Rouse, D., Al-Sarraj, S.

“…Immunohistochemistry staining for β‐amyloid precursor protein (β‐APP) is a sensitive method to detect early axonal damage in traumatic brain injury, which was…”
Get full text

Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration by Rohrer, Jonathan D., Lashley, Tammaryn, Schott, Jonathan M., Warren, Jane E., Mead, Simon, Isaacs, Adrian M., Beck, Jonathan, Hardy, John, de Silva, Rohan, Warrington, Elizabeth, Troakes, Claire, Al-Sarraj, Safa, King, Andrew, Borroni, Barbara, Clarkson, Matthew J., Ourselin, Sebastien, Holton, Janice L., Fox, Nick C., Revesz, Tamas, Rossor, Martin N., Warren, Jason D.

“…Relating clinical symptoms to neuroanatomical profiles of brain damage and ultimately to tissue pathology is a key challenge in the field of neurodegenerative…”
Get full text

Has the survival of patients with glioblastoma changed over the years? by deSouza, R M, Shaweis, H, Han, C, Sivasubramiam, V, Brazil, L, Beaney, R, Sadler, G, Al-Sarraj, S, Hampton, T, Logan, J, Hurwitz, V, Bhangoo, R, Gullan, R, Ashkan, K

“…Background: Over the last decade, the approach to the management of brain tumours and the understanding of glioblastoma tumour biology has advanced and a…”
Get full text

Changes in the expression of genes related to neuroinflammation over the course of sporadic Alzheimer’s disease progression: CX3CL1, TREM2, and PPARγ by Strobel, S., Grünblatt, E., Riederer, P., Heinsen, H., Arzberger, T., Al-Sarraj, S., Troakes, C., Ferrer, I., Monoranu, Camelia Maria

“…The role of neuroinflammation in the pathogenesis of neurodegenerative diseases has become more evident in recent years. Research on the etiology and…”
Get full text

Subacute necrotising encephalomyelopathy (Leigh's disease; Leigh syndrome) by Leigh, P N, Al-Sarraj, S, DiMauro, S

“…[...]he was proud of his role in identifying the disease bearing his name. LS can now be suspected and diagnosed in life through the biochemical profile of…”
Get full text

Fulminant corticobasal degeneration: a distinct variant with predominant neuronal tau aggregates by Ling, Helen, Gelpi, Ellen, Davey, Karen, Jaunmuktane, Zane, Mok, Kin Y., Jabbari, Edwin, Simone, Roberto, R’Bibo, Lea, Brandner, Sebastian, Ellis, Matthew J., Attems, Johannes, Mann, David, Halliday, Glenda M., Al-Sarraj, S., Hedreen, J., Ironside, James W., Kovacs, Gabor G., Kovari, E., Love, S., Vonsattel, Jean Paul G., Allinson, Kieren S. J., Hansen, Daniela, Bradshaw, Teisha, Setó-Salvia, Núria, Wray, Selina, de Silva, Rohan, Morris, Huw R., Warner, Thomas T., Hardy, John, Holton, Janice L., Revesz, Tamas

“…Corticobasal degeneration typically progresses gradually over 5–7 years from onset till death. Fulminant corticobasal degeneration cases with a rapidly…”
Get full text

The glial precursor proteoglycan, NG2, is expressed on tumour neovasculature by vascular pericytes in human malignant brain tumours by Chekenya, M., Enger, P. Ø., Thorsen, F., Tysnes, B. B., Al-Sarraj, S., Read, T. A., Furmanek, T., Mahesparan, R., Levine, J. M., Butt, A. M., Pilkington, G. J., Bjerkvig, R.

“…Glial precursor cells express NG2 and GD3 in the developing brain. These antigens are both over‐expressed during neoplasia, which suggests they may have…”
Get full text

Control tissue in brain banking: the importance of thorough neuropathological assessment by Nolan, M., Troakes, C., King, A., Bodi, I., Al-Sarraj, S.

“…Historically, control brain tissue was classified as such mainly by clinical history, and underwent limited neuropathological analysis. Significant progress…”
Get full text

Intracranial laterally based supratentorial neurenteric cyst by TAN, G. S, HORTOBAGYI, T, AL-SARRAJ, S, CONNOR, S. E. J

“…Neurenteric cysts are rare developmental cysts lined by endodermal derived epithelium. We present the case of a 68-year-old patient presenting with seizures…”
Get full text

Pilocytic astrocytoma of the adult--clinical features, radiological features and management by Bell, D, Chitnavis, BP, Al-Sarraj, S, Connor, S, Sharr, MM, Gullan, RW

“…Pilocytic astrocytoma is a histological subtype of astrocytoma classically located in the cerebellum of children and young adults. Cases occurring over the age…”
Get full text

Ubiquitin-only intraneuronal inclusion in the substantia nigra is a characteristic feature of motor neurone disease with dementia by Al-Sarraj, S., Maekawa, S., Kibble, M., Everall, I., Leigh, N.

“…Two types of ubiquitinated inclusions have been described in motor neurone disease (MND). (1) Skein or globular ubiquitinated inclusions in the motor neurones…”
Get full text