Search Results - "Al‐Kuraya, Khawla S."

Telomerase reverse transcriptase mutations are independent predictor of disease‐free survival in Middle Eastern papillary thyroid cancer by Bu, Rong, Siraj, Abdul K., Divya, Sasidharan Padmaja, Kong, Yan, Parvathareddy, Sandeep Kumar, Al‐Rasheed, Maha, Al‐Obaisi, Khadija A.S., Victoria, Ingrid G., Al‐Sobhi, Saif S., Al‐Dawish, Mohammed, Al‐Dayel, Fouad, Al‐Kuraya, Khawla S.

“…Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Tumor recurrence occurs in ∼20% of PTCs and some reach advanced stages. Promoter…”
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PLK1 and FoxM1 expressions positively correlate in papillary thyroid carcinoma and their combined inhibition results in synergistic anti‐tumor effects by Poyil, Pratheesh Kumar, Siraj, Abdul K., Padmaja, Divya, Parvathareddy, Sandeep Kumar, Thangavel, Saravanan, Alobaisi, Khadija, Diaz, Roxanne, Begum, Rafia, Haqawi, Wael, Al‐Sobhi, Saif S., Al‐Dayel, Fouad, Al‐Kuraya, Khawla S.

“…Polo‐like kinase 1 (PLK1; also known as serine/threonine‐protein kinase PLK1) serves as a central player in cell proliferation, exerting critical regulatory…”
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PALB2 germline mutations in a large cohort of Middle Eastern breast-ovarian cancer patients by Siraj, Abdul K., Bu, Rong, Parvathareddy, Sandeep Kumar, Iqbal, Kaleem, Azam, Saud, Qadri, Zeeshan, Al-Rasheed, Maha, Haqawi, Wael, Diaz, Mark, Victoria, Ingrid G., Al-Badawi, Ismail A., Tulbah, Asma, Al-Dayel, Fouad, Ajarim, Dahish, Al-Kuraya, Khawla S.

“…The PALB2 gene is a breast cancer (BC) and ovarian cancer (OC) predisposition gene involved in the homologous recombination repair pathway. However, the…”
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Cyclooxygenase‐2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer by Uddin, Shahab, Ahmed, Maqbool, Hussain, Azhar, Assad, Lina, Al‐Dayel, Fouad, Bavi, Prashant, Al‐Kuraya, Khawla S., Munkarah, Adnan

“…Cyclooxygenase‐2 (COX‐2) expression contributes to tumor growth and invasion in epithelial ovarian cancer (EOC). COX‐2 inhibitors exhibit important…”
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Overexpression of the pro‐protein convertase furin predicts prognosis and promotes papillary thyroid carcinoma progression and metastasis through RAF/MEK signaling by Poyil, Pratheesh Kumar, Siraj, Abdul K., Padmaja, Divya, Parvathareddy, Sandeep Kumar, Diaz, Roxanne, Thangavel, Saravanan, Begum, Rafia, Haqawi, Wael, Al‐Mohanna, Falah Hassan, Al‐Sobhi, Saif S., Al‐Dayel, Fouad, Al‐Kuraya, Khawla S.

“…Furin belongs to the pro‐protein convertases (PCs) family and its aberrant expression has been documented in various types of cancers; however, its role in…”
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Prevalence, spectrum, and founder effect of BRCA1 and BRCA2 mutations in epithelial ovarian cancer from the Middle East by Siraj, Abdul K., Bu, Rong, Iqbal, Kaleem, Siraj, Nabil, Al‐Haqawi, Wael, Al‐Badawi, Ismail A., Parvathareddy, Sandeep Kumar, Masoodi, Tariq, Tulbah, Asma, Al‐Dayel, Fouad, Al‐Kuraya, Khawla S.

“…Germline mutations in breast cancer susceptibility gene 1 and 2 have previously been estimated to contribute to 13–18% of all epithelial ovarian cancer (EOC)…”
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Tumor size is an independent negative prognostic factor for event free survival in children with differentiated thyroid cancer by Parvathareddy, Sandeep Kumar, Siraj, Abdul K., Annaiyappanaidu, Padmanaban, Siraj, Nabil, Haqawi, Wael, Al-Sobhi, Saif S., Al-Dayel, Fouad, Al-Kuraya, Khawla S.

“…BackgroundThe incidence of pediatric differentiated thyroid carcinoma (DTC) is increasing. Despite the advanced disease at presentation, the overall prognosis…”
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Prognostic significance of alterations in KRAS isoforms KRAS-4A/4B and KRAS mutations in colorectal carcinoma by Abubaker, Jehad, Bavi, Prashant, Al-Haqawi, Wael, Sultana, Mehar, Al-Harbi, Sayer, Al-Sanea, Nasser, Abduljabbar, Alaa, Ashari, Luai H, Alhomoud, Samar, Al-Dayel, Fouad, Uddin, Shahab, Al-Kuraya, Khawla S

“…Somatic KRAS mutation is an early well-known event in colorectal carcinogenesis but a complete understanding of RAS function and dysfunction in colorectal…”
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Frequent PIK3CA gene amplification and its clinical significance in colorectal cancer by Jehan, Zeenath, Bavi, Prashant, Sultana, Mehar, Abubaker, Jehad, Bu, Rong, Hussain, Azhar, Alsbeih, Ghazi, Al-Sanea, Nasser, Abduljabbar, Alaa, Ashari, Luai H, Alhomoud, Samar, Al-Dayel, Fouad, Uddin, Shahab, Al-Kuraya, Khawla S

“…Using a DNA microarray approach to screen for gene copy number changes in 20 colorectal (CR) carcinoma samples and filtering for high-level DNA copy number…”
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Genetic heterogeneity and evolutionary history of high-grade ovarian carcinoma and matched distant metastases by Masoodi, Tariq, Siraj, Sarah, Siraj, Abdul K., Azam, Saud, Qadri, Zeeshan, Parvathareddy, Sandeep K., Tulbah, Asma, Al-Dayel, Fouad, AlHusaini, Hamed, AlOmar, Osama, Al-Badawi, Ismail A., Alkuraya, Fowzan S., Al-Kuraya, Khawla S.

“…Background High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian carcinoma, associated with poor clinical outcome and metastatic…”
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POLE and POLD1 germline exonuclease domain pathogenic variants, a rare event in colorectal cancer from the Middle East by Siraj, Abdul K., Bu, Rong, Iqbal, Kaleem, Parvathareddy, Sandeep K., Masoodi, Tariq, Siraj, Nabil, Al‐Rasheed, Maha, Kong, Yan, Ahmed, Saeeda O., Al‐Obaisi, Khadija A. S., Victoria, Ingrid G., Arshad, Maham, Al‐Dayel, Fouad, Abduljabbar, Alaa, Ashari, Luai H., Al‐Kuraya, Khawla S.

“…Background Colorectal cancer (CRC) is a major contributor to morbidity and mortality related to cancer. Only ~5% of all CRCs occur as a result of pathogenic…”
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Differential expression of PD-L1 between primary and metastatic epithelial ovarian cancer and its clinico-pathological correlation by Parvathareddy, Sandeep Kumar, Siraj, Abdul K., Al-Badawi, Ismail A., Tulbah, Asma, Al-Dayel, Fouad, Al-Kuraya, Khawla S.

“…Ovarian cancer (OC) is one of the most common gynecologic cancer, which has the worst prognosis and highest mortality rate. The lack of curative treatment and…”
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Identification of novel BRCA founder mutations in Middle Eastern breast cancer patients using capture and Sanger sequencing analysis by Bu, Rong, Siraj, Abdul K., Al‐Obaisi, Khadija A.S., Beg, Shaham, Al Hazmi, Mohsen, Ajarim, Dahish, Tulbah, Asma, Al‐Dayel, Fouad, Al‐Kuraya, Khawla S.

“…Ethnic differences of breast cancer genomics have prompted us to investigate the spectra of BRCA1 and BRCA2 mutations in different populations. The prevalence…”
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Identification and characterization of ATM founder mutation in BRCA-negative breast cancer patients of Arab ethnicity by Bu, Rong, Siraj, Abdul K., Al-Rasheed, Maha, Iqbal, Kaleem, Azam, Saud, Qadri, Zeeshan, Haqawi, Wael, Tulbah, Asma, Al-Dayel, Fouad, Almalik, Osama, Al-Kuraya, Khawla S.

“…Breast cancer (BC) is the most prevalent malignancy among women worldwide with germline pathogenic variants/likely pathogenic variants (PVs/LPVs) in BRCA1/2…”
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Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis by Hussain, Azhar R, Ahmed, Saeeda O, Ahmed, Maqbool, Khan, Omar S, Al Abdulmohsen, Sally, Platanias, Leonidas C, Al-Kuraya, Khawla S, Uddin, Shahab

“…A number of constitutively activated signaling pathways play critical roles in the survival and growth of primary effusion lymphoma cells (PELs) including NFkB…”
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Loss of CDH16 expression is a strong independent predictor for lymph node metastasis in Middle Eastern papillary thyroid cancer by Siraj, Abdul K., Parvathareddy, Sandeep Kumar, Al-Rasheed, Maha, Annaiyappanaidu, Padmanaban, Siraj, Nabil, Lennartz, Maximilian, Al-Sobhi, Saif S., Al-Dayel, Fouad, Sauter, Guido, Al-Kuraya, Khawla S.

“…Papillary Thyroid Cancer (PTC) is the most common type of thyroid cancer. The membrane-associated glycoprotein cadherin-16 (CDH16) plays a significant role in…”
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Genomic Profiling of Thyroid Cancer Reveals a Role for Thyroglobulin in Metastasis by Siraj, Abdul K., Masoodi, Tariq, Bu, Rong, Beg, Shaham, Al-Sobhi, Saif S., Al-Dayel, Fouad, Al-Dawish, Mohammed, Alkuraya, Fowzan S., Al-Kuraya, Khawla S.

“…Papillary thyroid carcinoma (PTC) has a wide geographic variation in incidence; it is most common in Saudi Arabia, where it is only second to breast cancer as…”
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Genome-Wide Expression Analysis of Middle Eastern Colorectal Cancer Reveals FOXM1 as a Novel Target for Cancer Therapy by Uddin, Shahab, Ahmed, Maqbool, Hussain, Azhar, Abubaker, Jehad, Al-Sanea, Nasser, AbdulJabbar, Alaa, Ashari, Luai H, Alhomoud, Samar, Al-Dayel, Fouad, Jehan, Zeenath, Bavi, Prashant, Siraj, Abdul K, Al-Kuraya, Khawla S

“…To identify genes potentially playing an important role in the progression of colorectal carcinoma (CRC), we screened global gene expression using cDNA…”
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XIAP over-expression is an independent poor prognostic marker in Middle Eastern breast cancer and can be targeted to induce efficient apoptosis by Hussain, Azhar R, Siraj, Abdul Khalid, Ahmed, Maqbool, Bu, Rong, Pratheeshkumar, Poyil, Alrashed, Alanood M, Qadri, Zeeshan, Ajarim, Dahish, Al-Dayel, Fouad, Beg, Shaham, Al-Kuraya, Khawla S

“…Breast cancer is the most common cancer in females and is ranked second in cancer-related deaths all over the world in women. Despite improvement in diagnosis,…”
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Loss of ZNF677 Expression Is an Independent Predictor for Distant Metastasis in Middle Eastern Papillary Thyroid Carcinoma Patients by Siraj, Abdul K., Poyil, Pratheesh Kumar, Parvathareddy, Sandeep Kumar, Alobaisi, Khadija, Ahmed, Saeeda O., Al-Sobhi, Saif S., Al-Dayel, Fouad, Al-Kuraya, Khawla S.

“…Thyroid cancer incidence has increased in recent decades. Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Approximately 30% of PTC…”
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