Search Results - "Al‐Dosari, Mohammed S."

The anti‐hepatitis B virus therapeutic potential of anthraquinones derived from Aloe vera by Parvez, Mohammad K., Al‐Dosari, Mohammed S., Alam, Perwez, Rehman, MdTabish, Alajmi, Mohammed F., Alqahtani, Ali S.

“…Although the approved hepatitis B virus (HBV)‐polymerase inhibitors (e.g., lamivudine) often lead to drug‐resistance, several natural products have shown…”
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Methotrexate, an anti-inflammatory drug, inhibits Hepatitis E viral replication by Kumar, Akash, Hooda, Preeti, Puri, Anindita, Khatter, Radhika, S Al-Dosari, Mohammed, Sinha, Neha, Parvez, Mohammad K, Sehgal, Deepak

“…Hepatitis E Virus (HEV) is a positively oriented RNA virus having a 7.2 kb genome. HEV consists of three open reading frames (ORF1-3). Of these, ORF1 codes for…”
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Antiviral Natural Products Against Chronic Hepatitis B: Recent Developments by Parvez, Mohammad K, Arbab, Ahmed H, Al-Dosari, Mohammed S, Al-Rehaily, Adnan J

“…Hepatitis B virus (HBV) is inherently a hepatotropic virus that causes acute and chronic hepatitis in about one-third of world population. Of the estimated 360…”
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POC1A Truncation Mutation Causes a Ciliopathy in Humans Characterized by Primordial Dwarfism by Shaheen, Ranad, Faqeih, Eissa, Shamseldin, Hanan E., Noche, Ramil R., Sunker, Asma, Alshammari, Muneera J., Al-Sheddi, Tarfa, Adly, Nouran, Al-Dosari, Mohammed S., Megason, Sean G., Al-Husain, Muneera, Al-Mohanna, Futwan, Alkuraya, Fowzan S.

“…Primordial dwarfism (PD) is a phenotype characterized by profound growth retardation that is prenatal in onset. Significant strides have been made in the last…”
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3M Syndrome: An Easily Recognizable yet Underdiagnosed Cause of Proportionate Short Stature by Al-Dosari, Mohammed S., PhD, Al-Shammari, Muneera, MD, Shaheen, Ranad, PhD, Faqeih, Eissa, MD, AlGhofely, Mohammed A., MD, Boukai, Ahmad, MD, Alkuraya, Fowzan S., MD

“…Objective To characterize, via clinical and molecul criteria, a cohort of patients with 3M syndrome and thereby increase awareness of this syndrome as a…”
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In silico exploration of deep-sea fungal metabolites as inhibitor of Ebola and Marburg VP35 and VP40 by Alanzi, Abdullah R, Alajmi, Mohammed F, Al-Dosari, Mohammed S, Parvez, Mohammad K, Alqahtani, Moneerah J

“…VP30 and VP40 proteins of Ebola and Marburg viruses have been recognized as potential targets for antiviral drug development due to their essential roles in…”
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Plant-derived antiviral drugs as novel hepatitis B virus inhibitors: Cell culture and molecular docking study by Parvez, Mohammad K., Tabish Rehman, Md, Alam, Perwez, Al-Dosari, Mohammed S., Alqasoumi, Saleh I., Alajmi, Mohammed F.

“…Despite high anti-HBV efficacies, while the nucleoside analogs (e.g., lamivudine) lead to the emergence of drug-resistance, interferons (e.g., IFN-α causes…”
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‘Ajwa’ dates (Phoenix dactylifera L.) extract ameliorates isoproterenol-induced cardiomyopathy through downregulation of oxidative, inflammatory and apoptotic molecules in rodent model by Al-Yahya, Mohammed, Raish, Mohammad, AlSaid, Mansour S., Ahmad, Ajaz, Mothana, Ramzi A., Al-Sohaibani, Mohammed, Al-Dosari, Mohammed S., Parvez, Mohammad K., Rafatullah, Syed

“…Ajwa, a special variety of Saudi Arabian dates (Phoenix dactylifera L.) is a rich source of nutrients, fibers and bioactive molecules. While previous studies…”
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Expanding the clinical and genetic heterogeneity of hereditary disorders of connective tissue by Alazami, Anas M., Al-Qattan, Sarah M., Faqeih, Eissa, Alhashem, Amal, Alshammari, Muneera, Alzahrani, Fatema, Al-Dosari, Mohammed S., Patel, Nisha, Alsagheir, Afaf, Binabbas, Bassam, Alzaidan, Hamad, Alsiddiky, Abdulmonem, Alharbi, Nasser, Alfadhel, Majid, Kentab, Amal, Daza, Riza M., Kircher, Martin, Shendure, Jay, Hashem, Mais, Alshahrani, Saif, Rahbeeni, Zuhair, Khalifa, Ola, Shaheen, Ranad, Alkuraya, Fowzan S.

“…Ehlers–Danlos syndrome (EDS) describes a group of clinical entities in which the connective tissue, primarily that of the skin, joint and vessels, is abnormal,…”
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Organosulfurs, S-allyl cysteine and N-acetyl cysteine sequester di-carbonyls and reduces carbonyl stress in HT22 cells by Bhattacharya, Reshmee, Saini, Saakshi, Ghosh, Souvik, Roy, Partha, Ali, Nemat, Parvez, Mohammad Khalid, Al-Dosari, Mohammed S., Mishra, Awdhesh Kumar, Singh, Laishram Rajendrakumar

“…Diabetes, characterized by high blood glucose level, is a progressive metabolic disease that leads to serious health complications. One of the major…”
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Human Mutations in NDE1 Cause Extreme Microcephaly with Lissencephaly by Alkuraya, Fowzan S., Cai, Xuyu, Emery, Carina, Mochida, Ganeshwaran H., Al-Dosari, Mohammed S., Felie, Jillian M., Hill, R. Sean, Barry, Brenda J., Partlow, Jennifer N., Gascon, Generoso G., Kentab, Amal, Jan, Mohammad, Shaheen, Ranad, Feng, Yuanyi, Walsh, Christopher A.

“…Genes disrupted in human microcephaly (meaning “small brain”) define key regulators of neural progenitor proliferation and cell-fate specification. In…”
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Bioassay-guided isolation of anti-hepatitis B virus flavonoid myricetin-3-O-rhamnoside along with quercetin from Guiera senegalensis leaves by Parvez, Mohammad K., Al-Dosari, Mohammed S., Arbab, Ahmed H., Al-Rehaily, Adnan J., Abdelwahid, Mazin A.S.

“…Recently, we have shown in vitro anti-hepatitis B virus (HBV) activity of G. senegalensis J.F. Gmel leaves, and Identified quercetin and other flavonoids by…”
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Mutation in PHC1 implicates chromatin remodeling in primary microcephaly pathogenesis by Awad, Salma, Al-Dosari, Mohammed S, Al-Yacoub, Nadya, Colak, Dilek, Salih, Mustafa A, Alkuraya, Fowzan S, Poizat, Coralie

“…Primary microcephaly (PM) is a developmental disorder of early neuroprogenitors that results in reduction of the brain mass, particularly the cortex. To gain…”
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Isolation and Characterization of Two Chalcone Derivatives with Anti-Hepatitis B Virus Activity from the Endemic Socotraen Dracaena cinnabari (Dragon's Blood Tree) by Mothana, Ramzi A, Arbab, Ahmed H, ElGamal, Ali A, Parvez, Mohammad K, Al-Dosari, Mohammed S

“…Hepatitis B virus (HBV) infection is prevalent and continues to be a global health concern. In this study, we determined the anti-hepatitis B virus (HBV)…”
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Quantitative analysis of rutin, quercetin, naringenin, and gallic acid by validated RP- and NP-HPTLC methods for quality control of anti-HBV active extract of Guiera senegalensis by Alam, Perwez, Parvez, Mohammad K., Arbab, Ahmed H., Al-Dosari, Mohammed S.

“…Context: Guiera senegalensis J.F. Gmel (Combretaceae) is a folk medicinal plant used in various metabolic and infectious diseases. In addition to its antiviral…”
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Deep-sea fungal metabolites as potential inhibitors of glucose-regulatory enzymes: in silico structure-activity analysis by Alanzi, Abdullah R., Parvez, Mohammad K., Alqahtani, Moneerah J., Al-Dosari, Mohammed S.

“…Chronic diabetes mellites related hyperglycemia is a major cause of mortality and morbidity due to further complications like retinopathy, hypertension and…”
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CYP2C19 Genetic Polymorphism in Saudi Arabians by Al‐Jenoobi, Fahad I., Alkharfy, Khalid M., Alghamdi, Amal M., Bagulb, Khawla M., Al‐Mohizea, Abdullah M., Al‐Muhsen, Saleh, Halwani, Rabih, Parvez, Mohammad Khalid, Al‐Dosari, Mohammed S.

“…The main objective of this study was to evaluate CYP2C19 genetic polymorphism in a Saudi Arabian population by determining the frequencies of CYP2C19*2, *3,…”
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Novel anti‑hepatitis B virus flavonoids sakuranetin and velutin from Rhus retinorrhoea by Ahmed, Sarfaraz, Parvez, Mohammad K, Al-Dosari, Mohammed S, Abdelwahid, Mazin A S, Alhowiriny, Tawfeq A, Al-Rehaily, Adnan J

“…Drug‑resistance in hepatitis B virus (HBV), especially due to prolonged treatment with nucleoside analogs, such as lamivudine (LAM), remains a clinical…”
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Analysis of antioxidative and antiviral biomarkers β-amyrin, β-sitosterol, lupeol, ursolic acid in Guiera senegalensis leaves extract by validated HPTLC methods by Parvez, Mohammad K., Alam, Perwez, Arbab, Ahmed H., Al-Dosari, Mohammed S., Alhowiriny, Tawfeq A., Alqasoumi, Saleh I.

“…Guiera senegalensis J.F. Gmel is a broad-spectrum African folk- medicinal plant, having activities against fowlpox and herpes viruses. Very recently, we have…”
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Design, Synthesis and Anticancer Evaluation of Novel Quinazoline-Sulfonamide Hybrids by Ghorab, Mostafa M, Alsaid, Mansour S, Al-Dosari, Mohammed S, El-Gazzar, Marwa G, Parvez, Mohammad K

“…By combining the structural features of quinazoline and sulfonamides, novel hybrid compounds 2-21 were synthesized using a simple and convenient method…”
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