Search Results - "Akuwudike, Pamela"
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Impact of fractionated cisplatin and radiation treatment on cell growth and accumulation of DNA damage in two normal cell types differing in origin
Published in Scientific reports (09-09-2023)“…Evidence on the impact of chemotherapy on radiotherapy-induced second malignant neoplasms is controversial. We estimated how cisplatin modulates the in vitro…”
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Chromosomal damage, gene expression and alternative transcription in human lymphocytes exposed to mixed ionizing radiation as encountered in space
Published in Scientific reports (20-05-2024)“…Astronauts travelling in space will be exposed to mixed beams of particle radiation and photons. Exposure limits that correspond to defined cancer risk are…”
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Cell Type-Specific Patterns in the Accumulation of DNA Damage Following Multifractional Radiation Exposure
Published in International journal of molecular sciences (01-11-2022)“…Predicting the risk of second malignant neoplasms is complicated by uncertainties regarding the shape of the dose–response relationship at high doses. Limited…”
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Biological effectiveness of very high gamma dose rate and its implication for radiological protection
Published in Radiation and environmental biophysics (01-08-2020)“…Many experimental studies are carried out to compare biological effectiveness of high dose rate (HDR) with that of low dose rate (LDR). The rational for this…”
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Cisplatin Reduces the Frequencies of Radiotherapy-Induced Micronuclei in Peripheral Blood Lymphocytes of Patients with Gynaecological Cancer: Possible Implications for the Risk of Second Malignant Neoplasms
Published in Cells (Basel, Switzerland) (09-10-2021)“…Gynaecologic cancers are common among women and treatment includes surgery, radiotherapy or chemotherapy, where the last two methods induce DNA damage in…”
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Short- and long-term effects of radiation exposure at low dose and low dose rate in normal human VH10 fibroblasts
Published in Frontiers in public health (2023)“…Experimental studies complement epidemiological data on the biological effects of low doses and dose rates of ionizing radiation and help in determining the…”
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Mechanistic insights from high resolution DNA damage analysis to understand mixed radiation exposure
Published in DNA repair (01-10-2023)“…Cells exposed to densely ionising high and scattered low linear energy transfer (LET) radiation (50 % dose of each) react more strongly than to the same dose…”
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Small is beautiful: low activity alpha and gamma sources for small-scale radiation protection research experiments
Published in International journal of radiation biology (2021)“…Uncertainties regarding the magnitude of health effects following exposure to low doses of ionizing radiation remain a matter of concern both for professionals…”
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