Search Results - "Akutsu, Hidenori"

Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells by Akutsu, Hidenori, Apostolou, Effie, Shioda, Toshi, Stadtfeld, Matthias, Hochedlinger, Konrad, Follett, Patricia, Kono, Tomohiro, Natesan, Sridaran, Fukuda, Atsushi

“…Induced pluripotent stem cells (iPSCs) have been generated by enforced expression of defined sets of transcription factors in somatic cells. It remains…”
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Reduced Replication Efficacy of Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant in “Mini-gut” Organoids by Miyakawa, Kei, Machida, Masakazu, Kawasaki, Tomoyuki, Nishi, Mayuko, Akutsu, Hidenori, Ryo, Akihide

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DNA methylation dynamics in human induced pluripotent stem cells over time by Nishino, Koichiro, Toyoda, Masashi, Yamazaki-Inoue, Mayu, Fukawatase, Yoshihiro, Chikazawa, Emi, Sakaguchi, Hironari, Akutsu, Hidenori, Umezawa, Akihiro

“…Epigenetic reprogramming is a critical event in the generation of induced pluripotent stem cells (iPSCs). Here, we determined the DNA methylation profiles of…”
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MicroRNA-199a-3p, microRNA-193b, and microRNA-320c are correlated to aging and regulate human cartilage metabolism by Ukai, Taku, Sato, Masato, Akutsu, Hidenori, Umezawa, Akihiro, Mochida, Joji

“…MicroRNAs (miRNAs) are small RNAs of ∼22 base pairs that regulate gene expression. We harvested cartilage tissue from patients with polydactylism, anterior…”
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Mitochondrial Genetic Drift after Nuclear Transfer in Oocytes by Yamada, Mitsutoshi, Akashi, Kazuhiro, Ooka, Reina, Miyado, Kenji, Akutsu, Hidenori

“…Mitochondria are energy-producing intracellular organelles containing their own genetic material in the form of mitochondrial DNA (mtDNA), which codes for…”
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Autonomous trisomic rescue of Down syndrome cells by Inoue, Momoko, Kajiwara, Kazuhiro, Yamaguchi, Ayumi, Kiyono, Tohru, Samura, Osamu, Akutsu, Hidenori, Sago, Haruhiko, Okamoto, Aikou, Umezawa, Akihiro

“…Down syndrome is the most frequent chromosomal abnormality among live-born infants. All Down syndrome patients have mental retardation and are prone to develop…”
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DNMT1/PKR double knockdowned HepG2 (HepG2-DP) cells have high hepatic function and differentiation ability by Tanaka-yachi, Rieko, Aizawa, Kazuko, Shimizu, Kie, Akutsu, Hidenori, Nakamura, Kazuaki

“…HepG2 cells are widely used as a human hepatocytes model, but their functions, including drug metabolism, are inferior to primary hepatocytes. We previously…”
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Identification of an epigenetic signature in human induced pluripotent stem cells using a linear machine learning model by Nishino, Koichiro, Takasawa, Ken, Okamura, Kohji, Arai, Yoshikazu, Sekiya, Asato, Akutsu, Hidenori, Umezawa, Akihiro

“…The use of human induced pluripotent stem cells (iPSCs), used as an alternative to human embryonic stem cells (ESCs), is a potential solution to challenges,…”
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Alternative Method for Obtaining Human-Induced Pluripotent Stem Cell Lines and Three-Dimensional Growth: A Simplified, Passage-Free Approach that Minimizes Labor by Tsukamoto, Masaya, Kawasaki, Tomoyuki, Umezawa, Akihiro, Akutsu, Hidenori

“…Induced pluripotent stem cells (iPSCs) hold significant promise for numerous applications in regenerative medicine, disease modeling, and drug discovery…”
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Glycome Diagnosis of Human Induced Pluripotent Stem Cells Using Lectin Microarray by Tateno, Hiroaki, Toyota, Masashi, Saito, Shigeru, Onuma, Yasuko, Ito, Yuzuru, Hiemori, Keiko, Fukumura, Mihoko, Matsushima, Asako, Nakanishi, Mio, Ohnuma, Kiyoshi, Akutsu, Hidenori, Umezawa, Akihiro, Horimoto, Katsuhisa, Hirabayashi, Jun, Asashima, Makoto

“…Induced pluripotent stem cells (iPSCs) can now be produced from various somatic cell (SC) lines by ectopic expression of the four transcription factors…”
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Production of Functional Classical Brown Adipocytes from Human Pluripotent Stem Cells using Specific Hemopoietin Cocktail without Gene Transfer by Nishio, Miwako, Yoneshiro, Takeshi, Nakahara, Masako, Suzuki, Shinnosuke, Saeki, Koichi, Hasegawa, Mamoru, Kawai, Yuko, Akutsu, Hidenori, Umezawa, Akihiro, Yasuda, Kazuki, Tobe, Kazuyuki, Yuo, Akira, Kubota, Kazuo, Saito, Masayuki, Saeki, Kumiko

“…Brown adipose tissue is attracting much attention due to its antiobestic effects; however, its development and involvement in metabolic improvement remain…”
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Exploring trophoblast-specific Tead4 enhancers through chromatin conformation capture assays followed by functional screening by Tomikawa, Junko, Takada, Shuji, Okamura, Kohji, Terao, Miho, Ogata-Kawata, Hiroko, Akutsu, Hidenori, Tanaka, Satoshi, Hata, Kenichiro, Nakabayashi, Kazuhiko

“…Tead4 is critical for blastocyst development and trophoblast differentiation. We assayed long-range chromosomal interactions on the Tead4 promoter in mouse…”
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Odf2 haploinsufficiency causes a new type of decapitated and decaudated spermatozoa, Odf2-DDS, in mice by Ito, Chizuru, Akutsu, Hidenori, Yao, Ryoji, Yoshida, Keiichi, Yamatoya, Kenji, Mutoh, Tohru, Makino, Tsukasa, Aoyama, Kazuhiro, Ishikawa, Hiroaki, Kunimoto, Koshi, Tsukita, Sachiko, Noda, Tetsuo, Kikkawa, Masahide, Toshimori, Kiyotaka

“…Outer dense fibre 2 (Odf2 or ODF2) is a cytoskeletal protein required for flagella (tail)-beating and stability to transport sperm cells from testes to the…”
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Xenogeneic-Free Human Intestinal Organoids for Assessing Intestinal Nutrient Absorption by Inoue, Makoto, Tanaka, Yuichi, Matsushita, Sakiko, Shimozaki, Yuri, Ayame, Hirohito, Akutsu, Hidenori

“…Since many nutrients, including the three major ones of glucose, dipeptides, and cholesterol, are mainly absorbed in the small intestine, the assessment of…”
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The role of maternal-specific H3K9me3 modification in establishing imprinted X-chromosome inactivation and embryogenesis in mice by Fukuda, Atsushi, Tomikawa, Junko, Miura, Takumi, Hata, Kenichiro, Nakabayashi, Kazuhiko, Eggan, Kevin, Akutsu, Hidenori, Umezawa, Akihiro

“…Maintaining a single active X-chromosome by repressing Xist is crucial for embryonic development in mice. Although the Xist activator RNF12/RLIM is present as…”
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Imprinted X‐chromosome inactivation impacts primitive endoderm differentiation in mouse blastocysts by Fukuda, Atsushi, Motosugi, Nami, Ando, Mikiko, Kimura, Minoru, Umezawa, Akihiro, Akutsu, Hidenori

“…Epigenetic and transcriptome alterations are essential for lineage specification, represented by imprinted X‐chromosome inactivation (iXCI) in female mouse…”
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ROR2 expression predicts human induced pluripotent stem cell differentiation into neural stem/progenitor cells and GABAergic neurons by Kuroda, Takuya, Yasuda, Satoshi, Matsuyama, Satoko, Miura, Takumi, Sawada, Rumi, Matsuyama, Akifumi, Yamamoto, Yumiko, Morioka, Masaki Suimye, Kawaji, Hideya, Kasukawa, Takeya, Itoh, Masayoshi, Akutsu, Hidenori, Kawai, Jun, Sato, Yoji

“…Despite the development of various in vitro differentiation protocols for the efficient derivation of specific cell types, human induced pluripotent stem cell…”
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Spatiotemporally controlled delivery of soluble factors for stem cell differentiation by Kawada, Jiro, Kimura, Hiroshi, Akutsu, Hidenori, Sakai, Yasuyuki, Fujii, Teruo

“…Despite the fact that cells in vivo are largely affected by the spatial heterogeneity in their surroundings, in vitro experimental procedures for stem cell…”
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Efficient production of trophoblast lineage cells from human induced pluripotent stem cells by Kojima, Junya, Fukuda, Atsushi, Taira, Hayato, Kawasaki, Tomoyuki, Ito, Hiroe, Kuji, Naoaki, Isaka, Keiichi, Umezawa, Akihiro, Akutsu, Hidenori

“…Human induced pluripotent stem cells (hiPSCs) are potentially useful in both clinical applications and basic biological research. hiPSCs can differentiate into…”
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A single allele of the hsa-miR-302/367 cluster maintains human pluripotent stem cells by Sugawara, Tohru, Kawamoto, Yuki, Kawasaki, Tomoyuki, Umezawa, Akihiro, Akutsu, Hidenori

“…In a diploid organism, two alleles from a single genetic locus are expressed to generate a normal phenotype. Heterozygous deleterious mutation causes a…”
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