Search Results - "Akunne, H.C."

The pharmacology of the novel and selective sigma ligand, PD 144418 by AKUNNE, H. C, WHETZEL, S. Z, WILEY, J. N, CORBIN, A. E, NINTEMAN, F. W, TECLE, H, PEI, Y, PUGSLEY, T. A, HEFFNER, T. G

“…The pharmacology of PD 144418 (1-propyl-5-(3-p-tolyl-isoxazol-5-yl)-1,2,3,6-tetrahydropyridine) was characterized using neurochemical, biochemical and…”
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Neuropharmacological profile of a selective sigma ligand, igmesine: a potential antidepressant by Akunne, H.C, Zoski, K.T, Whetzel, S.Z, Cordon, J.J, Brandon, R.M, Roman, F, Pugsley, T.A

“…Igmesine is a selective sigma (σ 1) ligand that was reported to exert antidepressant action through an unknown mechanism of action. A number of neurochemical…”
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PD 158771, a potential antipsychotic agent with D 2/D 3 partial agonist and 5-HT 1A agonist actions. I. Neurochemical effects by Akunne, H.C, Zoski, K.T, Davis, M.D, Cooke, L.W, Meltzer, L.T, Whetzel, S.Z, Shih, Y.H, Wustrow, D.J, Wise, L.D, MacKenzie, R.G, Georgic, L.M, Heffner, T.G, Pugsley, T.A

“…The neurochemical effects of a novel dopamine (DA) D 2-like and serotonin (5-HT) 5-HT 1A agonist, PD 158771, are described. PD 158771 exhibited affinities for…”
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Reduced amide bond neurotensin 8–13 mimetics with potent in vivo activity by Wustrow, D.J., Davis, M.D., Akunne, H.C., Corbin, A.E., Wiley, J.N., Wise, L.D., Heffner, T.G.

“…Appropriately substituted 8–9 (ΨCH 2NH) isosteres of neurotensin (NT) 8–13 have been found which are active as NT agonists in vitro and in vivo. SAR studies…”
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PD 158771, a potential antipsychotic agent with D2/D3 partial agonist and 5-HT1A agonist actions. I. Neurochemical effects by AKUNNE, H. C, ZOSKI, K. T, GEORGIC, L. M, HEFFNER, T. G, PUGSLEY, T. A, DAVIS, M. D, COOKE, L. W, MELTZER, L. T, WHETZEL, S. Z, SHIH, Y. H, WUSTROW, D. J, WISE, L. D, MACKENZIE, R. G

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Differential effects of the nonpeptide neurotensin antagonist, SR 48692, on the pharmacological effects of neurotensin agonists by Pugsley, T.A., Akunne, H.C., Whetzel, S.Z., Demattos, S., Corbin, A.E., Wiley, J.N., Wustrow, D.J., Wise, L.D., Heffner, T.G.

“…In in vitro studies, SR 48692, a nonpeptide neurotensin receptor antagonist, inhibited the binding of [ 3H] or [ 125I]neurotensin to membrane preparations from…”
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Novel small molecule neurotensin antagonists: 3-(1,5-diaryl-1,5-dioxopentan-3-yl)benzoic acids by Johnson, S.J., Akunne, H.C., Heffner, T.G., Kesten, S.R., Pugsley, T.A., Wise, L.D., Wustrow, D.J.

“…Screening in a neurotensin (NT) receptor binding assay resulted in the discovery of compound 1 with NT receptor binding affinity of 450 nM. SAR studies that…”
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The role of opioid receptors in diabetes and hyperglycemia-induced changes in pain threshold in the rat by Akunne, H C, Soliman, K F

“…The role of opioid receptors in diabetes and hyperglycemia-induced analgesia was studied in male Sprague-Dawley rats. Animals maintained under controlled…”
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Functional activity of new C-terminal cyclic-neurotensin fragment analogs by Akunne, H.C, Darling, S, Zoski, K, Sefler, A.M, He, J.X, Sawyer, T.K, Pugsley, T.A, Cody, W.L

“…Neurotensin (NT, pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) is a tridecapeptide that displays a wide spectrum of biological actions. Cyclic…”
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