Search Results - "Akuffo, H."

Effect of deworming on human T cell responses to mycobacterial antigens in helminth‐exposed individuals before and after bacille Calmette–Guérin (BCG) vaccination by Elias, D., Wolday, D., Akuffo, H., Petros, B., Bronner, U., Britton, S.

“…The protective efficacy of BCG vaccination against pulmonary tuberculosis (TB) is highly variable in different populations. The reason remains to be…”
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Risk of tuberculous infection in adolescents and adults in a rural community in Ethiopia by Elias, D., Akuffo, H., Abate, E., Mekonnen, Y., Aseffa, A., Britton, S.

“…BACKGROUND: The incidence of tuberculosis (TB) in sub-Saharan Africa is one of the highest in the world.OBJECTIVE: To evaluate the prevalence of TB, the annual…”
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Leishmania surface protein gp63 binds directly to human natural killer cells and inhibits proliferation by Lieke, T, Nylén, S, Eidsmo, L, McMaster, W.R, Mohammadi, A.M, Khamesipour, A, Berg, L, Akuffo, H

“…Natural killer (NK) cells contribute to immunity as the first line of defence in numerous infections by early cytokine secretion and cytotoxicity. In…”
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Schistosoma mansoni infection reduces the protective efficacy of BCG vaccination against virulent Mycobacterium tuberculosis by Elias, Daniel, Akuffo, Hannah, Pawlowski, Andrzej, Haile, Melles, Schön, Thomas, Britton, Sven

“…We hypothesized that the ability of BCG vaccination to protect against Mycobacterium tuberculosis is less in hosts exposed to chronic helminthes infection…”
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PPD induced in vitro interferon gamma production is not a reliable correlate of protection against Mycobacterium tuberculosis by Elias, D., Akuffo, H., Britton, S.

“…Correlates of protection against tuberculosis are crucial for the evaluation of new vaccine candidates and for the demonstration of their potential efficacy…”
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Helminthes could influence the outcome of vaccines against TB in the tropics by ELIAS, D, AKUFFO, H, BRITTON, S

“…Helminthes, infections widespread in the tropics, are known to elicit a wide range of immunomodulation characterized by dominant Th2 type immune responses,…”
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Low dose chronic Schistosoma mansoni infection increases susceptibility to Mycobacterium bovis BCG infection in mice by Elias, D., Akuffo, H., Thors, C., Pawlowski, A., Britton, S.

“…Summary The incidence of mycobacterial diseases is high and the efficacy of Bacillus Calmette Guérin (BCG) is low in most areas of the world where chronic worm…”
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Contribution of human neutrophils in the development of protective immune response during in vitro Leishmania major infection by SAFAIYAN, S., BOLHASSANI, A., NYLEN, S., AKUFFO, H., RAFATI, S.

“…Summary Stimulation of neutrophils may potentiate immunity to Leishmania major. CpG‐containing oligodeoxynucleotide (ODN) has immune stimulatory effects and…”
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Live Leishmania promastigotes can directly activate primary human natural killer cells to produce interferon‐gamma by NYLÉN, S., MAASHO, K., SÖDERSTRÖM, K., ILG, T., AKUFFO, H.

“…Summary Natural killer (NK) cells have been implicated in the natural protection and healing of leishmaniasis by their ability to secrete the macrophage…”
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Leishmanial Amastigote Antigen P‐2 Induces Major Histocompatibility Complex Class II‐Dependent Natural Killer‐Cell Reactivity in Cells from Healthy Donors by Nylén, S., Maasho, K., McMahon‐Pratt, D., Akuffo, H.

“…Innate mechanisms involving natural killer cells have been implied to play an important role in immunity against Leishmania infection. Previous studies have…”
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A Leishmania Homologue of Receptors for Activated C-Kinase (LACK) Induces Both Interferon-γ and Interleukin-10 in Natural Killer Cells of Healthy Blood Donors by Maasho, Kerima, Satti, Iman, Nylén, Susanne, Guzman, Gabriel, Koning, Frits, Akuffo, Hannah

“…Natural killer (NK) cells from individuals unexposed to Leishmania organisms proliferate with high interferon (IFN)—γ secretion in response to crude Leishmania…”
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Alteration of Fas and Fas ligand expression during human visceral leishmaniasis by EIDSMO, L., WOLDAY, D., BERHE, N., SABRI, F., Satti, I., El Hassan, A. M., SUNDAR, S., CHIODI, F., Akuffo, H.

“…Summary Several studies in murine systems have suggested a role of apoptosis in the pathogenesis of leishmaniasis. However, the role of apoptosis in visceral…”
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Comparison between the skin snip test and simple dot blot assay as potential rapid assessment tools for Onchocerciasis in the postcontrol era in Ghana by Guzmán, G E, Awadzi, K, Opoku, N, Narayanan, R B, Akuffo, H O

“…Successful control of onchocerciasis through mass distribution of ivermectin needs to be coupled with reliable, sensitive, specific, yet affordable diagnostic…”
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Induction and abrogation of LACK reactive cells in the evolution of human leishmaniasis by Maasho, K., Wolday, D., Edjigu, M., Söderström, K., Britton, S., Akuffo, H.

“…Peripheral blood mononuclear cells (PBMC) from cutaneous leishmaniasis patients with ongoing Leishmania aethiopica infection and individuals cured/under…”
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New insights into leishmaniasis in the immunosuppressed by Akuffo, Hannah, Costa, Carlos, van Griensven, Johan, Burza, Sakib, Moreno, Javier, Herrero, Mercè

“…Immunosuppression contributes significantly to the caseload of visceral leishmaniasis (VL). HIV coinfection, solid organ transplantation, malnutrition, and…”
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Evaluation of amastigote reactive cells in human cutaneous leishmaniasis caused by Leishmania aethiopica by MAASHO, K., MCMAHON‐PRATT, D., RAITA, J., RAUD, M., BRITTON, S., SOONG, L., AKUFFO, H.

“…SUMMARY Lymphoproliferative responses to three affinity chromatography purified amastigote antigens of Leishmania pifanoi, P‐2, P‐4 and P‐8, were evaluated in…”
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Poor immunogenicity of BCG in helminth infected population is associated with increased in vitro TGF-β production by Elias, Daniel, Britton, Sven, Aseffa, Abraham, Engers, Howard, Akuffo, Hannah

“…Abstract The only vaccine available against tuberculosis (TB), BCG, so effective in experimental animal models, has been under scrutiny for a long time owing…”
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Differential induction of cellular responses by live and dead Leishmania promastigotes in healthy donors by Nylén, S., Mörtberg, U., Kovalenko, D., Satti, I., Engström, K., Bakhiet, M., Akuffo, H.

“…The most effective protection against human leishmaniasis has been achieved following vaccination with live promastigotes. Killed promastigotes + BCG can…”
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Drosophila antibacterial protein, cecropin A, differentially affects non-bacterial organisms such as Leishmania in a manner different from other amphipathic peptides by Akuffo, H, Hultmark, D, Engstöm, A, Frohlich, D, Kimbrell, D

“…The effects of the antibacterial protein Drosophila cecropin A on developmental forms of Leishmania were compared with the effect of Hyalophora cecropin A in…”
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Natural and acquired resistance to Leishmania: cellular activation by Leishmania aethiopica of mononuclear cells from unexposed individuals is through the stimulation of natural killer (NK) cells by AKUFFO, H., MAASHO, K., HOWE, R.

“…SUMMARY Cells from normal non‐Leishmania‐exposed individuals could respond in vitro by proliferation and interferon‐gamma (IFN‐γ) production to Leishmania…”
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