Search Results - "Akthar, Ihshan"

Sperm activate TLR2/TLR1 heterodimerization to induce a weak proinflammatory response in the bovine uterus by Mansouri, Alireza, Yousef, Mohamed Samy, Kowsar, Rasoul, Usui, Nonoka, Akthar, Ihshan, Miyamoto, Akio

“…Toll-like receptor 2 (TLR2) signaling pathway is involved in the sperm-triggered uterine inflammatory response at insemination, but its precise mechanism at…”
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Sperm enter glands of preovulatory bovine endometrial explants and initiate inflammation by Akthar, Ihshan, Suarez, Susan S, Morillo, Vernadyn A, Sasaki, Motoki, Ezz, Mohamed A, Takahashi, Ken-ichi, Shimada, Masayuki, Marey, Mohamed A, Miyamoto, Akio

“…We previously reported that sperm binding to cultured monolayers of bovine uterine epithelial cells induces an acute inflammatory response involving the…”
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Hyaluronan regulates sperm-induced inflammatory response by enhancing sperm attachment to bovine endometrial epithelial cells via CD44: in-silico and in-vitro approaches by Ezz, Mohamed Aboul, Mansouri, Alireza, Akthar, Ihshan, Yousef, Mohamed Samy, Kowsar, Rasoul, Miyamoto, Akio

“…Recently, we reported that sperm induce cluster of differentiation 44 (CD44) expression and Toll-like receptor 2 (TLR2)-mediated inflammatory response in…”
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Activation of sperm Toll-like receptor 2 induces hyperactivation to enhance the penetration to mucus and uterine glands: a trigger for the uterine inflammatory cascade in cattle by Akthar, Ihshan, Kim, Yejin, Umehara, Takashi, Kanno, Chihiro, Sasaki, Motoki, Marey, Mohamed Ali, Yousef, Mohamed Samy, Haneda, Shingo, Shimada, Masayuki, Miyamoto, Akio

“…It is known that sperm and seminal plasma (SP) affect uterine immunity. In cattle, artificial insemination enables breeding by depositing frozen and largely…”
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Toll‐like receptor 2 mediates the immune response of the bovine oviductal ampulla to sperm binding by Morillo, Vernadyn A., Akthar, Ihshan, Fiorenza, Mariani F., Takahashi, Ken‐ichi, Sasaki, Motoki, Marey, Mohamed A., Suarez, Susan S., Miyamoto, Akio

“…A differentiated bovine ampullar explant model was used to observe bull heparin treated and nontreated sperm interaction with preovulatory ampullar epithelium…”
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Peptidoglycan Switches Off the TLR2-Mediated Sperm Recognition and Triggers Sperm Localization in the Bovine Endometrium by Elesh, Ibrahim Fouad, Marey, Mohamed Ali, Zinnah, Mohammed Ali, Akthar, Ihshan, Kawai, Tomoko, Naim, Fayrouz, Goda, Wael, Rawash, Abdel Rahman A, Sasaki, Motoki, Shimada, Masayuki, Miyamoto, Akio

“…In mammals, the uterine mucosal immune system simultaneously recognizes and reacts to most bacteria as well as allogenic sperm mainly through the Toll-like…”
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Sensing sperm via maternal immune system: a potential mechanism for controlling microenvironment for fertility in the cow by Marey, Mohamed Ali, Aboul Ezz, Mohamed, Akthar, Ihshan, Yousef, Mohamed Samy, Imakawa, Kazuhiko, Shimada, Masayuki, Miyamoto, Akio

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Sperm interaction with the uterine innate immune system: toll-like receptor 2 (TLR2) is a main sensor in cattle by Akthar, Ihshan, Marey, Mohamed A, Kim, Yejin, Shimada, Masayuki, Suarez, Susan S, Miyamoto, Akio

“…During the passage through the female reproductive tract, sperm interact with various compartments and their immune systems. The immune system that protects…”
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In vitro regulation of gene expression of pregnancy-associated proteins and cytokines in bovine endometrial epithelial cells and bovine trophoblastic cells by infection with Neospora caninum by Abdelbaky, Hanan H., Shimoda, Naomi, Akthar, Ihshan, Nakamura, Shu, Hasan, Md Hasibul, Ushio, Nanako, Miyamoto, Akio, Nishikawa, Yoshifumi

“…Abortion caused by the parasite Neospora caninum is an important threat to the livestock industry worldwide. Trophoblasts and caruncular cells play major roles…”
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In vitro and in vivo impairment of embryo implantation by commonly used fungicide Mancozeb by Akthar, Ihshan, Wang, Ziyi, Wijayagunawardane, Missaka P.B., Ratnayake, Chathura J., Siriweera, Eranga H., Lee, Kai-Fai, Kodithuwakku, Suranga P.

“…The fungicide Mancozeb is an endocrine-disrupting chemical and the mode of action of Mancozeb on embryo implantation is largely unknown. Mancozeb (1 and…”
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Sensing sperm via maternal immune system: a potential mechanism for controlling microenvironment for fertility in the cow by Marey, Mohamed Ali, Ezz, Mohamed Aboul, Akthar, Ihshan, Yousef, Mohamed Samy, Imakawa, Kazuhiko, Shimada, Masayuki, Miyamoto, Akio

“…Both the uterus and oviduct are functionally adapted to facilitate sperm transport, oocyte fertilization, embryonic/fetal development, and deliver a calf…”
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Sperm hyperactivation in the uterus and oviduct: a double-edged sword for sperm and maternal innate immunity toward fertility by Akthar, Ihshan, Yousef, Mohamed Samy, Mansouri, Alireza, Shimada, Masayuki, Miyamoto, Akio

“…In cattle, artificial insemination (AI) is a technique that allows breeding by depositing frozen-thawed and extended semen into the female reproductive tract…”
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The growth hormone and insulin‐like growth factor 1 axis in cattle during the peri‐ovulatory period activates the synthesis and release of oviductal contraction related substances by Kodithuwakku, Suranga P., Akthar, Ihshan, Muhandiram, Subhashini, Wijayagunawardhana, Missaka P. B., Miyamoto, Akio

“…Growth hormone (GH) and insulin‐like growth factor 1 (IGF1) are crucial for female reproductive functions. The cyclic regulation of the local GH/IGF1 axis in…”
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Zearalenone interferes with the sperm-triggered inflammation in the bovine uterus in vitro: Negative impact on sperm motility and survival by Elweza, Ahmed E., Marey, Mohamed A., Elesh, Ibrahim F., Zinnah, Mohammad A., Akthar, Ihshan, Kanno, Chihiro, Takagi, Mitsuhiro, Miyamoto, Akio

“…•Zearalenone (ZEN) induced pro-inflammatory responses in bovine endometrial epithelial cells.•Pre-exposure of endometrial epithelium to ZEN, amplified the…”
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