Search Results - "Aktary, Zackie"

Plakoglobin represses SATB1 expression and decreases in vitro proliferation, migration and invasion by Aktary, Zackie, Pasdar, Manijeh

“…Plakoglobin (γ-catenin) is a homolog of β-catenin with dual adhesive and signaling functions. Plakoglobin participates in cell-cell adhesion as a component of…”
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Plakoglobin: Role in Tumorigenesis and Metastasis by Aktary, Zackie, Pasdar, Manijeh

“…Plakoglobin (γ-catenin) is a member of the Armadillo family of proteins and a homolog of β-catenin. As a component of both the adherens junctions and…”
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Simulation of melanoblast displacements reveals new features of developmental migration by Laurent-Gengoux, Pascal, Petit, Valérie, Aktary, Zackie, Gallagher, Stuart, Tweedy, Luke, Machesky, Laura, Larue, Lionel

“…To distribute and establish the melanocyte lineage throughout the skin and other developing organs, melanoblasts undergo several rounds of proliferation,…”
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BRN2 is a non-canonical melanoma tumor-suppressor by Hamm, Michael, Sohier, Pierre, Petit, Valérie, Raymond, Jérémy H., Delmas, Véronique, Le Coz, Madeleine, Gesbert, Franck, Kenny, Colin, Aktary, Zackie, Pouteaux, Marie, Rambow, Florian, Sarasin, Alain, Charoenchon, Nisamanee, Bellacosa, Alfonso, Sanchez-del-Campo, Luis, Mosteo, Laura, Lauss, Martin, Meijer, Dies, Steingrimsson, Eirikur, Jönsson, Göran B., Cornell, Robert A., Davidson, Irwin, Goding, Colin R., Larue, Lionel

“…While the major drivers of melanoma initiation, including activation of NRAS/BRAF and loss of PTEN or CDKN2A , have been identified, the role of key…”
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Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis by Aktary, Zackie, Alaee, Mahsa, Pasdar, Manijeh

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A role for Dynlt3 in melanosome movement, distribution, acidity and transfer by Aktary, Zackie, Conde-Perez, Alejandro, Rambow, Florian, Di Marco, Mathilde, Amblard, François, Hurbain, Ilse, Raposo, Graça, Delevoye, Cédric, Coscoy, Sylvie, Larue, Lionel

“…Skin pigmentation is dependent on cellular processes including melanosome biogenesis, transport, maturation and transfer to keratinocytes. However, how the…”
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Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis by Aktary, Zackie, Alaee, Mahsa, Pasdar, Manijeh

“…Plakoglobin (also known as γ-catenin) is a member of the Armadillo family of proteins and a paralog of β-catenin. Plakoglobin is a component of both the…”
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UVB radiation suppresses Dicer expression through β-catenin by Aktary, Zackie, Petit, Valérie, Berlin, Irina, Raymond, Jeremy, Berger, Frederique, Charoenchon, Nisamanee, Sage, Evelyne, Bertrand, Juliette, Larue, Lionel

“…Ultraviolet (UV) rays prompt a natural response in epidermal cells, particularly within melanocytes. The changes in gene expression and related signaling…”
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Sequencing two Tyr::CreERT2 transgenic mouse lines by Aktary, Zackie, Corvelo, Andre, Estrin, Camille, Larue, Lionel

“…The Cre/loxP system is a powerful tool that has allowed the study of the effects of specific genes of interest in various biological settings. The Tyr::CreERT2…”
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Sequencing two Tyr::CreER T2 transgenic mouse lines by Aktary, Zackie, Corvelo, Andre, Estrin, Camille, Larue, Lionel

“…The Cre/loxP system is a powerful tool that has allowed the study of the effects of specific genes of interest in various biological settings. The Tyr::CreER…”
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The WNT-less wonder: WNT-independent β-catenin signaling by Aktary, Zackie, Bertrand, Juliette U., Larue, Lionel

“…Summary β‐catenin is known as an Armadillo protein that regulates gene expression following WNT pathway activation. However, WNT‐independent pathways also…”
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Plakoglobin interacts with the transcription factor p53 and regulates the expression of 14-3-3σ by Aktary, Zackie, Kulak, Stephen, Mackey, John, Jahroudi, Nadia, Pasdar, Manijeh

“…Plakoglobin (γ-catenin), a constituent of the adherens junction and desmosomes, has signaling capabilities typically associated with tumor/metastasis…”
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Derivation and Use of Cell Lines from Mouse Models of Melanoma by Aktary, Zackie, Raymond, Jeremy H., Pouteaux, Marie, Delmas, Véronique, Petit, Valérie, Larue, Lionel

“…The establishment of consistent genetically modified mouse melanoma models and cell lines is of paramount importance for prevention and treatment. In this…”
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Abstract 1185: Plakoglobin (β-catenin) interacts with the transcription factor p53 and regulates the expression of genes involved in tumorigenesis and metastasis by Aktary, Zackie, Pasdar, Manijeh

“…Plakoglobin (β-catenin) and β-catenin are highly homologous proteins that function in cell-cell adhesion and signaling. Both proteins exist in a…”
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Stabilization of β-catenin promotes melanocyte specification at the expense of the Schwann cell lineage by Colombo, Sophie, Petit, Valérie, Wagner, Roselyne Y, Champeval, Delphine, Yajima, Ichiro, Gesbert, Franck, Aktary, Zackie, Davidson, Irwin, Delmas, Véronique, Larue, Lionel

“…The canonical Wnt/β-catenin pathway governs a multitude of developmental processes in various cell lineages, including the melanocyte lineage. Indeed,…”
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The WNT-less wonder: WNT-independent [beta]-catenin signaling by Aktary, Zackie, Bertrand, Juliette U, Larue, Lionel

“…Summary [beta]-catenin is known as an Armadillo protein that regulates gene expression following WNT pathway activation. However, WNT-independent pathways also…”
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Targeting GPCRs and Their Signaling as a Therapeutic Option in Melanoma by Raymond, Jérémy H, Aktary, Zackie, Larue, Lionel, Delmas, Véronique

“…G-protein-coupled receptors (GPCRs) serve prominent roles in melanocyte lineage physiology, with an impact at all stages of development, as well as on mature…”
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Targeted Knockout of β-Catenin in Adult Melanocyte Stem Cells Using a Mouse Line, Dct::CreERT2, Results in Disrupted Stem Cell Renewal and Pigmentation Defects by Le Coz, Madeleine, Aktary, Zackie, Watanabe, Natsuki, Yajima, Ichiro, Pouteaux, Marie, Charoenchon, Nisamanee, Motohashi, Tsutomu, Kunisada, Takahiro, Corvelo, André, Larue, Lionel

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A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity by Conde-Perez, Alejandro, Gros, Gwendoline, Longvert, Christine, Pedersen, Malin, Petit, Valérie, Aktary, Zackie, Viros, Amaya, Gesbert, Franck, Delmas, Véronique, Rambow, Florian, Bastian, Boris C., Campbell, Andrew D., Colombo, Sophie, Puig, Isabel, Bellacosa, Alfonso, Sansom, Owen, Marais, Richard, Van Kempen, Leon C. L. T., Larue, Lionel

“…Loss of the tumour suppressor PTEN is frequent in human melanoma, results in MAPK activation, suppresses senescence and mediates metastatic behaviour. How PTEN…”
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A histopathological classification system of Tyr::NRAS Q61K murine melanocytic lesions: A reproducible simplified classification by Sohier, Pierre, Legrand, Léa, Aktary, Zackie, Grill, Christine, Delmas, Véronique, Bernex, Florence, Reyes-Gomez, Edouard, Larue, Lionel, Vergier, Béatrice

“…Genetically engineered mouse models offer essential opportunities to investigate the mechanisms of initiation and progression in melanoma. Here, we report a…”
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