Comparison of Efficacy and Side Effects of Oral Baclofen Versus Tizanidine Therapy with Adjuvant Botulinum Toxin Type A in Children With Cerebral Palsy and Spastic Equinus Foot Deformity

This retrospective study aimed to compare the therapeutic response, including side effects, for oral baclofen versus oral tizanidine therapy with adjuvant botulinum toxin type A in a group of 64 pediatric patients diagnosed with static encephalopathy and spastic equinus foot deformity. Following bot...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of child neurology Vol. 31; no. 2; pp. 184 - 189
Main Authors:	Dai, Alper I., Aksoy, Sefika N., Demiryürek, Abdullah T.
Format:	Journal Article
Language:	English
Published:	Los Angeles, CA SAGE Publications 01-02-2016
Subjects:	Administration, Oral Adolescent Baclofen - administration & dosage Baclofen - adverse effects Botulinum Toxins, Type A - administration & dosage Botulinum Toxins, Type A - adverse effects Cerebral Palsy - complications Cerebral Palsy - drug therapy Child Child, Preschool Clonidine - administration & dosage Clonidine - adverse effects Clonidine - analogs & derivatives Drug Therapy, Combination - adverse effects Equinus Deformity - complications Equinus Deformity - drug therapy Female Follow-Up Studies Humans Male Muscle Spasticity - complications Muscle Spasticity - drug therapy Neuromuscular Agents - administration & dosage Neuromuscular Agents - adverse effects Retrospective Studies Severity of Illness Index Treatment Outcome botulinum toxin cerebral palsy tizanidine adverse effect baclofen
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	This retrospective study aimed to compare the therapeutic response, including side effects, for oral baclofen versus oral tizanidine therapy with adjuvant botulinum toxin type A in a group of 64 pediatric patients diagnosed with static encephalopathy and spastic equinus foot deformity. Following botulinum toxin A treatment, clinical improvement led to the gradual reduction of baclofen or tizanidine dosing to one-third of the former dose. Gross Motor Functional Measure and Caregiver Health Questionnaire scores were markedly elevated post–botulinum toxin A treatment, with scores for the tizanidine (Gross Motor Functional Measure: 74.45 ± 3.72; Caregiver Health Questionnaire: 72.43 ± 4.29) group significantly higher than for the baclofen group (Gross Motor Functional Measure: 68.23 ± 2.66; Caregiver Health Questionnaire: 67.53 ± 2.67, P < .001). These findings suggest that the combined use of botulinum toxin A and a low dose of tizanidine in treating children with cerebral palsy appears to be more effective and has fewer side effects versus baclofen with adjuvant botulinum toxin A.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0883-0738 1708-8283
DOI:	10.1177/0883073815587030