Search Results - "Akslen, L A"
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A novel age-related gene expression signature associates with proliferation and disease progression in breast cancer
Published in British journal of cancer (09-11-2022)“…Background and objective Breast cancer (BC) diagnosed at ages <40 years presents with more aggressive tumour phenotypes and poorer clinical outcome compared to…”
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2
Molecular subtypes, histopathological grade and survival in a historic cohort of breast cancer patients
Published in Breast cancer research and treatment (01-08-2013)“…Molecular subtyping of breast cancer may provide additional prognostic information regarding patient outcome. However, its clinical significance remains to be…”
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Elevated expression of Aurora-A/AURKA in breast cancer associates with younger age and aggressive features
Published in Breast cancer research : BCR (28-08-2024)“…Aurora kinase A (AURKA) is reported to be overexpressed in breast cancer. In addition to its role in regulating cell cycle and mitosis, studies have reported…”
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4
Integrated Genomic Profiling of Endometrial Carcinoma Associates Aggressive Tumors with Indicators of PI3 Kinase Activation
Published in Proceedings of the National Academy of Sciences - PNAS (24-03-2009)“…Although 75% of endometrial cancers are treated at an early stage, 15% to 20% of these recur. We performed an integrated analysis of genome-wide expression and…”
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5
Pre-diagnostic high-sensitive C-reactive protein and breast cancer risk, recurrence, and survival
Published in Breast cancer research and treatment (01-01-2016)“…Inflammation may initiate and promote breast cancer development, and be associated with elevated circulating levels of inflammation markers. A total of eight…”
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6
Body size and thyroid cancer in two million Norwegian men and women
Published in British journal of cancer (07-08-2006)“…We investigated relations between measured body mass index (BMI) and stature and thyroid cancer (3046 cases) in a large Norwegian cohort of more than two…”
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7
Expression of EZH2 and Ki-67 in colorectal cancer and associations with treatment response and prognosis
Published in British journal of cancer (20-10-2009)“…Background: Enhancer of zeste homologue 2 (EZH2) is a member of the Polycomb group of genes that is involved in epigenetic silencing and cell cycle regulation…”
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Asparaginase‐like protein 1 expression in curettage independently predicts lymph node metastasis in endometrial carcinoma: a multicentre study
Published in BJOG : an international journal of obstetrics and gynaecology (01-12-2018)“…Objective Correct preoperative identification of high‐risk patients is important to optimise surgical treatment and improve survival. We wanted to explore if…”
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9
KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer
Published in British journal of cancer (04-12-2012)“…Background: Three quarter of endometrial carcinomas are treated at early stage. Still, 15 to 20% of these patients experience recurrence, with little effect…”
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10
Increased microvascular proliferation is negatively correlated to tumour blood flow and is associated with unfavourable outcome in endometrial carcinomas
Published in British journal of cancer (07-01-2014)“…Background: We aimed to study the angiogenic profile based on histomorphological markers in endometrial carcinomas in relation to imaging parameters obtained…”
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Loss of GPER identifies new targets for therapy among a subgroup of ERα-positive endometrial cancer patients with poor outcome
Published in British journal of cancer (08-05-2012)“…Background: The G protein-coupled oestrogen receptor, GPER, has been suggested as an alternative oestrogen receptor. Our purpose was to investigate the…”
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12
High BMI is significantly associated with positive progesterone receptor status and clinico-pathological markers for non-aggressive disease in endometrial cancer
Published in British journal of cancer (15-03-2011)“…Background: Endometrial cancer incidence is increasing in industrialised countries. High body mass index (BMI, kg m −2 ) is associated with higher risk for…”
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13
Independent prognostic value of the basal-like phenotype of breast cancer and associations with EGFR and candidate stem cell marker BMI-1
Published in Histopathology (01-02-2008)“…Aims: To study the relationship between basal‐like breast cancers, epidermal growth factor receptor (EGFR) and candidate stem cell markers (BMI‐1, EZH2,…”
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14
Glomeruloid microvascular proliferation is associated with lack of response to chemotherapy in breast cancer
Published in British journal of cancer (28-06-2011)“…Background: Glomeruloid microvascular proliferation (GMP), a novel histology-based angiogenesis marker, has been associated with decreased survival in several…”
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15
Low BMI-1 expression is associated with an activated BMI-1-driven signature, vascular invasion, and hormone receptor loss in endometrial carcinoma
Published in British journal of cancer (20-05-2008)“…We studied the expression of polycomb group (PcG) protein BMI-1 in a large population-based patient series of endometrial carcinomas in relation to clinical…”
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Strong expression of ID1 protein is associated with decreased survival, increased expression of ephrin-A1 EPHA2, and reduced thrombospondin-1 in malignant melanoma
Published in British journal of cancer (17-10-2005)“…The ID1 protein, an inhibitor of basic helix-loop-helix transcription factors, has been involved in multiple cellular processes including cell cycle…”
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Prognostic significance of histologic grading compared with subclassification of papillary thyroid carcinoma
Published in Cancer (15-04-2000)“…BACKGROUND Papillary thyroid carcinomas represent a diversity of morphologic subtypes and variants, but to the authors' knowledge the prognostic significance…”
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Expression of epidermal growth factor receptor in relation to BRCA1 status, basal-like markers and prognosis in breast cancer
Published in Journal of clinical pathology (01-02-2009)“…BRCA1-related breast cancer is associated with a basal-like phenotype, and is frequently oestrogen receptor (ER) and HER2 negative. The expression of epidermal…”
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Women treated with breast conserving surgery do better than those with mastectomy independent of detection mode, prognostic and predictive tumor characteristics
Published in European journal of surgical oncology (01-10-2015)“…Abstract Background Primary breast conserving treatment (BCT) is well known to have similar long-term survival as mastectomy in breast cancer patients…”
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Significance of tumour‐associated macrophages, vascular endothelial growth factor and thrombospondin‐1 expression for tumour angiogenesis and prognosis in endometrial carcinomas
Published in International journal of cancer (22-10-1999)“…Angiogenesis is a key process in tumour growth and metastasis, and microvessel density has been found to influence the prognosis of endometrial carcinoma…”
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