Cognitive Impairment in Multiple Sclerosis

Multiple sclerosis (MS) is a socially significant immune-mediated disease, characterized by demyelination, axonal transection and oligodendropathy in the central nervous system. Inflammatory demyelination and neurodegeneration lead to brain atrophy and cognitive deficit in up to 75% of the patients....

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Bibliographic Details
Published in:	Folia Medica Vol. 58; no. 3; pp. 157 - 163
Main Authors:	Trenova, Anastasiya G, Slavov, Georgi S, Manova, Maria G, Aksentieva, Jana B, Miteva, Lyuba D, Stanilova, Spaska A
Format:	Journal Article
Language:	English
Published:	Bulgaria MEDICAL UNIVERSITY- PLOVDIV 01-09-2016 Pensoft Publishers
Subjects:	Central Nervous System - pathology Cognitive Dysfunction - etiology Cognitive Dysfunction - pathology Cognitive Dysfunction - therapy cognitive impairment Disease Progression Humans multiple sclerosis Multiple Sclerosis - complications Multiple Sclerosis - pathology neuropsychological tests Quality of Life
Online Access:	Get full text
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Summary:	Multiple sclerosis (MS) is a socially significant immune-mediated disease, characterized by demyelination, axonal transection and oligodendropathy in the central nervous system. Inflammatory demyelination and neurodegeneration lead to brain atrophy and cognitive deficit in up to 75% of the patients. Cognitive dysfunctions impact significantly patients' quality of life, independently from the course and phase of the disease. The relationship between pathological brain findings and cognitive impairment is a subject of intensive research. Summarizing recent data about prevalence, clinical specificity and treatment of cognitive disorders in MS, this review aims to motivate the necessity of early diagnosis and complex therapeutic approach to these disturbances in order to reduce the social burden of the disease.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0204-8043 1314-2143
DOI:	10.1515/folmed-2016-0029