Search Results - "Aksenov, Dmitrii A."

A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams by Aksenov, Alexander V, Aksenov, Dmitrii A, Kurenkov, Igor A, Leontiev, Alexander V, Aksenov, Nicolai A

“…The synthesis of novel, highly functionalized 5-hydroxy 3-pyrrolin-2-ones via a two-step procedure involving an addition reaction between KCN and corresponding…”
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An Effective Synthesis of Previously Unknown 7-Aryl Substituted Paullones by Aksenov, Dmitrii A, Akulova, Alesia S, Aleksandrova, Elena A, Aksenov, Nicolai A, Leontiev, Alexander V, Aksenov, Alexander V

“…A straightforward three-step procedure affording a wide range of novel 7-aryl substituted paullone derivatives was developed. This scaffold is structurally…”
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Metal-Free, PPA-Mediated Fisher Indole Synthesis via Tandem Hydroamination-Cyclization Reaction between Simple Alkynes and Arylhydrazines by Aksenov, Alexander V, Makieva, Dinara C, Arestov, Rodion A, Arutiunov, Nikolai A, Aksenov, Dmitrii A, Aksenov, Nicolai A, Leontiev, Alexander V, Aksenova, Inna V

“…A new variant of Fisher indole synthesis involving Bronsted acid-catalyzed hydrohydrazination of unactivated terminal and internal acetylenes with…”
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One-Pot Synthesis of Polynuclear Indole Derivatives by Friedel-Crafts Alkylation of γ-Hydroxybutyrolactams by Abaev, Vladimir T, Aksenov, Nicolai A, Aksenov, Dmitrii A, Aleksandrova, Elena V, Akulova, Alesia S, Kurenkov, Igor A, Leontiev, Alexander V, Aksenov, Alexander V

“…The Friedel-Crafts reaction of novel 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones was used for low cost, one-pot preparation of polycyclic…”
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Synthesis of β-Carbolines with Electrocyclic Cyclization of 3-Nitrovinylindoles by Aksenov, Nicolai A., Arutiunov, Nikolai A., Aksenov, Alexander V., Kirilov, Nikita K., Aksenova, Inna V., Aksenov, Dmitrii A., Aleksandrova, Elena V., Rubin, Michael, Kornienko, Alexander

“…The β-carboline motif is common in drug discovery and among numerous biologically active natural products. However, its synthetic preparation relies on…”
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One-Pot Synthesis of ( E )-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles by Aksenov, Nicolai A, Aksenov, Alexander V, Kurenkov, Igor A, Kirillov, Nikita K, Aksenov, Dmitrii A, Arutiunov, Nikolai A, Aksenova, Daria S, Rubin, Michael

“…A highly efficient and expeditious one-pot approach towards 2-(3-oxoindolin-2-yl)acetonitriles was designed, which involves a base-assisted aldol reaction of…”
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Direct Conversion of 3-(2-Nitroethyl)-1H-Indoles into 2-(1H-Indol-2-yl)Acetonitriles by Aksenov, Alexander V., Aksenov, Nicolai A., Aleksandrova, Elena V., Aksenov, Dmitrii A., Grishin, Igor Yu, Sorokina, Elena A., Wenger, Allison, Rubin, Michael

“…The recently discovered [4+1]-spirocyclization of nitroalkenes to indoles provided a convenient new approach to 2-(1H-indol-2-yl)acetonitriles. However, this…”
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A Convenient Way to Quinoxaline Derivatives through the Reaction of 2-(3-Oxoindolin-2-yl)-2-phenylacetonitriles with Benzene-1,2-diamines by Aksenov, Alexander V., Arutiunov, Nikolai A., Aksenov, Dmitrii A., Samovolov, Artem V., Kurenkov, Igor A., Aksenov, Nicolai A., Aleksandrova, Elena A., Momotova, Daria S., Rubin, Michael

“…Microwave-assisted reaction between 2-(3-oxoindolin-2-yl)-2-phenylacetonitriles andbenzene-1,2-diamines leads to the high-yielding formation of the…”
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Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3- a ]quinolines and 1,3,4-Oxadiazole Rings by Aksenov, Alexander V, Kirilov, Nikita K, Aksenov, Nicolai A, Aksenov, Dmitrii A, Sorokina, Elena A, Lower, Carolyn, Rubin, Michael

“…Nitroalkanes activated with polyphosphoric acid could serve as efficient electrophiles in reactions with amines and hydrazines, enabling various cascade…”
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Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines by Aksenov, Alexander V, Grishin, Igor Yu, Aksenov, Nicolai A, Malyuga, Vladimir V, Aksenov, Dmitrii A, Nobi, Mezvah A, Rubin, Michael

“…Nitroalkanes activated with polyphosphoric acid serve as efficient electrophiles in reactions with various nucleophilic amines. Strategically placed second…”
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A Two-Step Synthesis of Unprotected 3-Aminoindoles via Post Functionalization with Nitrostyrene by Aksenov, Nicolai A, Arutiunov, Nikolai A, Kurenkov, Igor A, Malyuga, Vladimir V, Aksenov, Dmitrii A, Momotova, Daria S, Zatsepilina, Anna M, Chukanova, Elizaveta A, Leontiev, Alexander V, Aksenov, Alexander V

“…A novel, low-cost method for the preparation of not easily accessible free 3-aminoindoles has been developed. This approach is based on a well-established…”
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Improved Method for Preparation of 3-(1 H -Indol-3-yl)benzofuran-2(3 H )-ones by Grishin, Igor Yu, Arutiunov, Nikolai A, Aksenov, Dmitrii A, Aksenov, Nicolai A, Aksenov, Alexander V, Gasanova, Amina Z, Sorokina, Elena A, Lower, Carolyn, Rubin, Michael

“…3-(1 -Indol-3-yl)benzofuran-2(3 )-ones were efficiently accessed via polyphosphoric acid-mediated condensation of 3-(2-nitrovinyl)-1 -indoles with phenols…”
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One-Pot Synthesis of N‑Fused Quinolone‑4 Tetracyclic Scaffolds from 2,2-Disubstituted Indolin-3-ones by Arutiunov, Nikolai A., Zatsepilina, Anna M., Aksenova, Anna A., Aksenov, Nicolai A., Aksenov, Dmitrii A., Leontiev, Alexander V., Aksenov, Alexander V.

“…A cascade transformation of C2-quaternary indoxyls leading to an efficient assembly of complex (dihydro)­indolo­[1,2-a]­quinolin-5-one ring systems is…”
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Synthesis of imidazo[1,5- a ]pyridines via cyclocondensation of 2-(aminomethyl)pyridines with electrophilically activated nitroalkanes by Aksenov, Dmitrii A, Arutiunov, Nikolai A, Maliuga, Vladimir V, Aksenov, Alexander V, Rubin, Michael

“…Imidazo[1,5- ]pyridines were efficiently prepared via the cyclization of 2-picolylamines with nitroalkanes electrophilically activated in the presence of…”
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Electrophilically Activated Nitroalkanes in Reactions With Carbon Based Nucleophiles by Aksenov, Nicolai A, Aksenov, Alexander V, Ovcharov, Sergei N, Aksenov, Dmitrii A, Rubin, Michael

“…Unusual reactivity of nitroalkanes, involving formation of aci-forms (nitronic acids or nitronates) and their subsequent interaction with carbon-based…”
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Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic Acids and Evaluation of Cytotoxic Activity of the Products by Aksenov, Dmitrii A., Aksenov, Alexander V., Prityko, Lidiya A., Aksenov, Nicolai A., Frolova, Liliya V., Rubin, Michael

“…2-Aryl-2-(3-indolyl)acetohydroxamic acids demonstrate promising antitumor activity, but quickly metabolize in vivo via glucuronidation of hydroxamic acid…”
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Synthesis of Spiro[indole-3,5′-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles by Aksenov, Alexander V, Aksenov, Dmitrii A, Arutiunov, Nikolai A, Aksenov, Nicolai A, Aleksandrova, Elena V, Zhao, Zhenze, Du, Liqin, Kornienko, Alexander, Rubin, Michael

“…An acid-assisted [4 + 1]-cycloaddition of indoles with nitrostyrenes affords 4′H-spiro­[indole-3,5′-isoxazoles] in a diastereomerically pure form. Several of…”
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Nitrovinylindoles as Heterotrienes: Electrocyclic Cyclization En Route to β‑Carbolines: Total Synthesis of Alkaloids Norharmane, Harmane, and Eudistomin N by Aksenov, Nicolai A., Arutiunov, Nikolai A., Aksenov, Alexander V., Aksenova, Inna V., Aleksandrova, Elena V., Aksenov, Dmitrii A., Rubin, Michael

“…Unusual cascade transformation was developed involving microwave assisted electrocyclic cyclization of aci (alkylideneazinic acid) forms of nitrovinylindoles…”
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A Diastereoselective Assembly of Tetralone Derivatives via a Tandem Michael Reaction and ipso-Substitution of the Nitro Group by Aksenov, Nicolai A., Aksenov, Dmitrii A., Ganusenko, Daniil D., Kurenkov, Igor A., Aksenov, Alexander V.

“…A highly diastereoselective tandem reaction of 2′-nitrochalcones is reported, involving Michael addition and a subsequent ipso-substitution of the nitro group…”
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Syntheses of 3‑(2-Nitrovinyl)-indoles, Benzo[a]carbazoles, Naphtho[2,1‑a]carbazoles, and 1‑Hydroxy-β-carbolines Lead to Identification of Antiproliferative Compounds Active under Hypoxia by Arutiunov, Nikolai A., Edvall, Connor, Aksenov, Alexander V., Aksenov, Dmitrii A., Kurenkov, Igor A., Aksenova, Inna V., Zatsepilina, Anna M., Aksenov, Nicolai A., Mallik, Sanku, Kornienko, Alexander

“…Herein, we describe a novel reaction between C-2-substituted indoles and 2-nitroacetophenones leading to a variety of indole-containing heterocyclic scaffolds…”
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