Search Results - "Akrap, Nina"

Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing by Peterka, Martin, Akrap, Nina, Li, Songyuan, Wimberger, Sandra, Hsieh, Pei-Pei, Degtev, Dmitrii, Bestas, Burcu, Barr, Jack, van de Plassche, Stijn, Mendoza-Garcia, Patricia, Šviković, Saša, Sienski, Grzegorz, Firth, Mike, Maresca, Marcello

“…Prime editing recently emerged as a next-generation approach for precise genome editing. Here we exploit DNA double-strand break (DSB) repair to develop two…”
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Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing by Wimberger, Sandra, Akrap, Nina, Firth, Mike, Brengdahl, Johan, Engberg, Susanna, Schwinn, Marie K., Slater, Michael R., Lundin, Anders, Hsieh, Pei-Pei, Li, Songyuan, Cerboni, Silvia, Sumner, Jonathan, Bestas, Burcu, Schiffthaler, Bastian, Magnusson, Björn, Di Castro, Silvio, Iyer, Preeti, Bohlooly-Y, Mohammad, Machleidt, Thomas, Rees, Steve, Engkvist, Ola, Norris, Tyrell, Cadogan, Elaine B., Forment, Josep V., Šviković, Saša, Akcakaya, Pinar, Taheri-Ghahfarokhi, Amir, Maresca, Marcello

“…Genome editing, specifically CRISPR/Cas9 technology, has revolutionized biomedical research and offers potential cures for genetic diseases. Despite rapid…”
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The mevalonate precursor enzyme HMGCS1 is a novel marker and key mediator of cancer stem cell enrichment in luminal and basal models of breast cancer by Walsh, Claire A, Akrap, Nina, Garre, Elena, Magnusson, Ylva, Harrison, Hannah, Andersson, Daniel, Jonasson, Emma, Rafnsdottir, Svanheidur, Choudhry, Hani, Buffa, Francesca, Ragoussis, Jiannis, Ståhlberg, Anders, Harris, Adrian, Landberg, Göran

“…The definitive characterization of common cancer stem cell (CSCs) subpopulations in breast cancer subtypes with distinct genotypic and phenotypic features…”
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Identification of Distinct Breast Cancer Stem Cell Populations Based on Single-Cell Analyses of Functionally Enriched Stem and Progenitor Pools by Akrap, Nina, Andersson, Daniel, Bom, Eva, Gregersson, Pernilla, Ståhlberg, Anders, Landberg, Göran

“…The identification of breast cancer cell subpopulations featuring truly malignant stem cell qualities is a challenge due to the complexity of the disease and…”
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Distinct mechanisms of resistance to fulvestrant treatment dictate level of ER independence and selective response to CDK inhibitors in metastatic breast cancer by Kaminska, Kamila, Akrap, Nina, Staaf, Johan, Alves, Carla L, Ehinger, Anna, Ebbesson, Anna, Hedenfalk, Ingrid, Beumers, Lukas, Veerla, Srinivas, Harbst, Katja, Ehmsen, Sidse, Borgquist, Signe, Borg, Åke, Pérez-Fidalgo, Alejandro, Ditzel, Henrik J, Bosch, Ana, Honeth, Gabriella

“…Resistance to endocrine treatment in metastatic breast cancer is a major clinical challenge. Clinical tools to predict both drug resistance and possible…”
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Author Correction: Universal toxin-based selection for precise genome engineering in human cells by Li, Songyuan, Akrap, Nina, Cerboni, Silvia, Porritt, Michelle J., Wimberger, Sandra, Lundin, Anders, Möller, Carl, Firth, Mike, Gordon, Euan, Lazovic, Bojana, Sieńska, Aleksandra, Pane, Luna Simona, Coelho, Matthew A., Ciotta, Giovanni, Pellegrini, Giovanni, Sini, Marcella, Xu, Xiufeng, Mitra, Suman, Bohlooly-Y, Mohammad, Taylor, Benjamin J. M., Sienski, Grzegorz, Maresca, Marcello

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Universal toxin-based selection for precise genome engineering in human cells by Li, Songyuan, Akrap, Nina, Cerboni, Silvia, Porritt, Michelle J., Wimberger, Sandra, Lundin, Anders, Möller, Carl, Firth, Mike, Gordon, Euan, Lazovic, Bojana, Sieńska, Aleksandra, Pane, Luna Simona, Coelho, Matthew A., Ciotta, Giovanni, Pellegrini, Giovanni, Sini, Marcella, Xu, Xiufeng, Mitra, Suman, Bohlooly-Y, Mohammad, Taylor, Benjamin J. M., Sienski, Grzegorz, Maresca, Marcello

“…Prokaryotic restriction enzymes, recombinases and Cas proteins are powerful DNA engineering and genome editing tools. However, in many primary cell types, the…”
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Elements of transcriptional machinery are compatible among plants and mammals by Wolf, Annette, Akrap, Nina, Marg, Berenice, Galliardt, Helena, Heiligentag, Martyna, Humpert, Fabian, Sauer, Markus, Kaltschmidt, Barbara, Kaltschmidt, Christian, Seidel, Thorsten

“…In the present work, the objective has been to analyse the compatibility of plant and human transcriptional machinery. The experiments revealed that nuclear…”
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TLX controls angiogenesis through interaction with the von Hippel-Lindau protein by Zeng, Zhao-Jun, Johansson, Erik, Hayashi, Amiko, Chavali, Pavithra L, Akrap, Nina, Yoshida, Takeshi, Kohno, Kimitoshi, Izumi, Hiroto, Funa, Keiko

“…TLX is known as the orphan nuclear receptor indispensable for maintaining neural stem cells in adult neurogenesis. We report here that neuroblastoma cell lines…”
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Förster distances for fluorescence resonant energy transfer between mCherry and other visible fluorescent proteins by Akrap, Nina, Seidel, Thorsten, Barisas, B. George

“…We present, for the red fluorescent protein mCherry acting as both fluorescence resonant energy transfer (FRET) donor and acceptor, Förster critical distance (…”
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Abstract 5907: Fulvestrant resistance in estrogen receptor positive breast cancer models is driven by heterogeneous ER independent transcriptional programs by Kaminska, Kamila K., Akrap, Nina, Staaf, Johan, Borg, Åke, Bosch, Ana, Honeth, Gabriella

“…Abstract Endocrine therapy is the mainstay of treatment for metastatic estrogen receptor (ER) positive breast cancer. The selective ER degrader (SERD)…”
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Properties of targeted preamplification in DNA and cDNA quantification by Andersson, Daniel, Akrap, Nina, Svec, David, Godfrey, Tony E, Kubista, Mikael, Landberg, Göran, Ståhlberg, Anders

“…Quantification of small molecule numbers often requires preamplification to generate enough copies for accurate downstream enumerations. Here, we studied…”
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Cell Cycle and Cell Size Dependent Gene Expression Reveals Distinct Subpopulations at Single-Cell Level by Dolatabadi, Soheila, Candia, Julián, Akrap, Nina, Vannas, Christoffer, Tesan Tomic, Tajana, Losert, Wolfgang, Landberg, Göran, Åman, Pierre, Ståhlberg, Anders

“…Cell proliferation includes a series of events that is tightly regulated by several checkpoints and layers of control mechanisms. Most studies have been…”
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Abstract LB-49: Defining hierarchical organization of breast cancer cells and cancer activated fibroblasts using single-cell gene expression profiling: switch-like and transient transitions between novel stem cell and progenitor pools by Ståhlberg, Anders, Akrap, Nina, Andersson, Daniel, Gregersson, Pernilla, Busch, Susann, Landberg, Göran P.

“…Abstract The cancer stem cell (CSC) model holds that cancers are organized in a hierarchical structure and derived from cellular populations with stem cell…”
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Förster distances for FRET between mCherry and other Visible Fluorescent Proteins by Akrap, Nina, Seidel, Thorsten, Barisas, B. George

“…We present, for the red fluorescent protein mCherry acting as both FRET donor and acceptor, r 0 values with five important VFP variants as well as with itself…”
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Robotic Mammosphere Assay for High-Throughput Screening in Triple-Negative Breast Cancer by Fitzpatrick, P A, Akrap, N, Söderberg, E M V, Harrison, H, Thomson, G J, Landberg, G

“…In order to identify novel treatment principles specifically affecting cancer stem cells in triple-negative breast cancer, we have developed a high-throughput…”
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