Search Results - "Akram, Ahsan R"

Spacer-free BODIPY fluorogens in antimicrobial peptides for direct imaging of fungal infection in human tissue by Mendive-Tapia, Lorena, Zhao, Can, Akram, Ahsan R., Preciado, Sara, Albericio, Fernando, Lee, Martin, Serrels, Alan, Kielland, Nicola, Read, Nick D, Lavilla, Rodolfo, Vendrell, Marc

“…Fluorescent antimicrobial peptides are promising structures for in situ , real-time imaging of fungal infection. Here we report a fluorogenic probe to image…”
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Full spectrum fluorescence lifetime imaging with 0.5 nm spectral and 50 ps temporal resolution by Williams, Gareth O. S., Williams, Elvira, Finlayson, Neil, Erdogan, Ahmet T., Wang, Qiang, Fernandes, Susan, Akram, Ahsan R., Dhaliwal, Kev, Henderson, Robert K., Girkin, John M., Bradley, Mark

“…The use of optical techniques to interrogate wide ranging samples from semiconductors to biological tissue for rapid analysis and diagnostics has gained wide…”
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Cancer Associated Fibroblasts - An Impediment to Effective Anti-Cancer T Cell Immunity by Koppensteiner, Lilian, Mathieson, Layla, O'Connor, Richard A, Akram, Ahsan R

“…The presence of functionally efficient cytotoxic T lymphocytes (CTL) in the Tumour nest is crucial in mediating a successful immune response to cancer. The…”
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Cancer-associated fibroblasts drive CXCL13 production in activated T cells via TGF-beta by O'Connor, Richard A, Martinez, Begoña Roman, Koppensteiner, Lilian, Mathieson, Layla, Akram, Ahsan R

“…Tumour-reactive T cells producing the B-cell attractant chemokine CXCL13, in solid tumours, promote development of tertiary lymphoid structures (TLS) and are…”
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A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies by Scott, Jamie I., Mendive-Tapia, Lorena, Gordon, Doireann, Barth, Nicole D., Thompson, Emily J., Cheng, Zhiming, Taggart, David, Kitamura, Takanori, Bravo-Blas, Alberto, Roberts, Edward W., Juarez-Jimenez, Jordi, Michel, Julien, Piet, Berber, de Vries, I. Jolanda, Verdoes, Martijn, Dawson, John, Carragher, Neil O., Connor, Richard A. O’, Akram, Ahsan R., Frame, Margaret, Serrels, Alan, Vendrell, Marc

“…Immunotherapy promotes the attack of cancer cells by the immune system; however, it is difficult to detect early responses before changes in tumor size occur…”
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Understanding patient barriers and facilitators to uptake of lung screening using low dose computed tomography: a mixed methods scoping review of the current literature by Cavers, Debbie, Nelson, Mia, Rostron, Jasmin, Robb, Kathryn A, Brown, Lynsey R, Campbell, Christine, Akram, Ahsan R, Dickie, Graeme, Mackean, Melanie, van Beek, Edwin J R, Sullivan, Frank, Steele, Robert J, Neilson, Aileen R, Weller, David

“…Targeted lung cancer screening is effective in reducing mortality by upwards of twenty percent. However, screening is not universally available and uptake is…”
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Location of CD39+ T cell subpopulations within tumors predict differential outcomes in non-small cell lung cancer by Koppensteiner, Lilian, Mathieson, Layla, Pattle, Samuel, Dorward, David A, O’Connor, Richard, Akram, Ahsan R

“…PurposeAn improved mechanistic understanding of immunosuppressive pathways in non-small cell lung cancer (NSCLC) is important to develop novel diagnostic and…”
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T cells drive negative feedback mechanisms in cancer associated fibroblasts, promoting expression of co-inhibitory ligands, CD73 and IL-27 in non-small cell lung cancer by O'Connor, Richard A, Chauhan, Vishwani, Mathieson, Layla, Titmarsh, Helen, Koppensteiner, Lilian, Young, Irene, Tagliavini, Giulia, Dorward, David A, Prost, Sandrine, Dhaliwal, Kevin, Wallace, William A, Akram, Ahsan R

“…The success of immune checkpoint therapy shows tumor-reactive T cells can eliminate cancer cells but are restrained by immunosuppression within the tumor…”
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Enhanced avidity from a multivalent fluorescent antimicrobial peptide enables pathogen detection in a human lung model by Akram, Ahsan R., Avlonitis, Nicolaos, Scholefield, Emma, Vendrell, Marc, McDonald, Neil, Aslam, Tashfeen, Craven, Thomas H., Gray, Calum, Collie, David S., Fisher, Andrew J., Corris, Paul A., Walsh, Timothy, Haslett, Christopher, Bradley, Mark, Dhaliwal, Kevin

“…Rapid in situ detection of pathogens coupled with high resolution imaging in the distal human lung has the potential to provide new insights and diagnostic…”
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Activated neutrophil fluorescent imaging technique for human lungs by Craven, Thomas H., Walton, Tashfeen, Akram, Ahsan R., Scholefield, Emma, McDonald, Neil, Marshall, Adam D.L., Humphries, Duncan C., Mills, Bethany, Campbell, Thane A., Bruce, Annya, Mair, Joanne, Dear, James W., Newby, David E., Hill, Adam T., Walsh, Timothy S., Haslett, Chris, Dhaliwal, Kevin

“…Neutrophil activation is an integral process to acute inflammation and is associated with adverse clinical sequelae. Identification of neutrophil activation in…”
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Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: Phase 1b/2a experimental study to investigate safety, Pharmacokinetics and Pharmacodynamics by Quinn, Tom M., Gaughan, Erin E., Bruce, Annya, Antonelli, Jean, O'Connor, Richard, Li, Feng, McNamara, Sarah, Koch, Oliver, MacKintosh, Claire, Dockrell, David, Walsh, Timothy, Blyth, Kevin G., Church, Colin, Schwarze, Jürgen, Boz, Cecilia, Valanciute, Asta, Burgess, Matthew, Emanuel, Philip, Mills, Bethany, Rinaldi, Giulia, Hardisty, Gareth, Mills, Ross, Findlay, Emily Gwyer, Jabbal, Sunny, Duncan, Andrew, Plant, Sinéad, Marshall, Adam D.L., Young, Irene, Russell, Kay, Scholefield, Emma, Nimmo, Alastair F., Nazarov, Islom B., Churchill, Grant C., McCullagh, James S.O., Ebrahimi, Kourosh H., Ferrett, Colin, Templeton, Kate, Rannard, Steve, Owen, Andrew, Moore, Anne, Finlayson, Keith, Shankar-Hari, Manu, Norrie, John, Parker, Richard A., Akram, Ahsan R., Anthony, Daniel C., Dear, James W., Hirani, Nik, Dhaliwal, Kevin

“…Many repurposed drugs have progressed rapidly to Phase 2 and 3 trials in COVID19 without characterisation of Pharmacokinetics /Pharmacodynamics including…”
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Quantitative proteomics identifies tumour matrisome signatures in patients with non-small cell lung cancer by Titmarsh, Helen F, von Kriegsheim, Alex, Wills, Jimi C, O'Connor, Richard A, Dhaliwal, Kevin, Frame, Margaret C, Pattle, Samuel B, Dorward, David A, Byron, Adam, Akram, Ahsan R

“…The composition and remodelling of the extracellular matrix (ECM) are important factors in the development and progression of cancers, and the ECM is…”
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Systematic review of studies investigating ventilator associated pneumonia diagnostics in intensive care by Al-Omari, Basem, McMeekin, Peter, Allen, A. Joy, Akram, Ahsan R, Graziadio, Sara, Suklan, Jana, Jones, William S, Lendrem, B. Clare, Winter, Amanda, Cullinan, Milo, Gray, Joanne, Dhaliwal, Kevin, Walsh, Timothy S, Craven, Thomas H

“…Abstract Background Ventilator-associated pneumonia (VAP) is an important diagnosis in critical care. VAP research is complicated by the lack of agreed…”
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Optimizing the implementation of lung cancer screening in Scotland: Focus group participant perspectives in the LUNGSCOT study by Cavers, Debbie, Nelson, Mia, Rostron, Jasmin, Robb, Kathryn A., Brown, Lynsey R., Campbell, Christine, Akram, Ahsan R., Dickie, Graeme, Mackean, Melanie, Beek, Edwin J. R., Sullivan, Frank, Steele, Robert J., Neilson, Aileen R., Weller, David

“…Introduction Targeted lung cancer screening is effective in reducing lung cancer and all‐cause mortality according to major trials in the United Kingdom and…”
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Corrigendum: The Emerging Role of the c-MET-HGF Axis in Non-small Cell Lung Cancer Tumor Immunology and Immunotherapy by Titmarsh, Helen F., O'Connor, Richard, Dhaliwal, Kevin, Akram, Ahsan R.

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Fibroblast Activation Protein Specific Optical Imaging in Non-Small Cell Lung Cancer by Mathieson, Layla, O'Connor, Richard A, Stewart, Hazel, Shaw, Paige, Dhaliwal, Kevin, Williams, Gareth O S, Megia-Fernandez, Alicia, Akram, Ahsan R

“…Fibroblast activation protein (FAP) is a cell surface propyl-specific serine protease involved in the regulation of extracellular matrix. Whilst expressed at…”
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The Emerging Role of the c-MET-HGF Axis in Non-small Cell Lung Cancer Tumor Immunology and Immunotherapy by Titmarsh, Helen F, O'Connor, Richard, Dhaliwal, Kevin, Akram, Ahsan R

“…Study of the c-Met-HGF axis in non-small cell lung cancer (NSCLC) has focused on the roles of c-MET signaling in neoplastic epithelial cells and the secretion…”
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Optical Detection of Distal Lung Enzyme Activity in Human Inflammatory Lung Disease by Megia-Fernandez, Alicia, Marshall, Adam, Akram, Ahsan R, Mills, Bethany, Chankeshwara, Sunay V, Scholefield, Emma, Miele, Amy, McGorum, Bruce C, Michaels, Chesney, Knighton, Nathan, Vercauteren, Tom, Lacombe, Francois, Dentan, Veronique, Bruce, Annya M, Mair, Joanne, Hitchcock, Robert, Hirani, Nik, Haslett, Chris, Bradley, Mark, Dhaliwal, Kevin

“…There is a need to develop platforms delineating inflammatory biology of the distal human lung. We describe a platform technology approach to detect enzyme…”
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Erratum to "Optical Detection of Distal Lung Enzyme Activity in Human Inflammatory Lung Disease" by Megia-Fernandez, Alicia, Marshall, Adam, Akram, Ahsan R, Mills, Bethany, Chankeshwara, Sunay V, Scholefield, Emma, Miele, Amy, McGorum, Bruce C, Michaels, Chesney, Knighton, Nathan, Vercauteren, Tom, Lacombe, Francois, Dentan, Veronique, Bruce, Annya M, Mair, Joanne, Hitchcock, Robert, Hirani, Nik, Haslett, Chris, Bradley, Mark, Dhaliwal, Kevin

“…[This corrects the article DOI: 10.34133/2021/9834163.]…”
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Estimating Bacterial and Cellular Load in FCFM Imaging by Seth, Sohan, Akram, Ahsan, Dhaliwal, Kevin, Williams, Christopher

“…We address the task of estimating bacterial and cellular load in the human distal lung with fibered confocal fluorescence microscopy (FCFM). In pulmonary FCFM…”
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