Search Results - "Akopian, Tatos N."

  • Showing 1 - 10 results of 10
Refine Results
  1. 1

    Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection by Raju, Ravikiran M, Unnikrishnan, Meera, Rubin, Daniel H F, Krishnamoorthy, Vidhya, Kandror, Olga, Akopian, Tatos N, Goldberg, Alfred L, Rubin, Eric J

    Published in PLoS pathogens (01-02-2012)
    “…In most bacteria, Clp protease is a conserved, non-essential serine protease that regulates the response to various stresses. Mycobacteria, including…”
    Get full text
    Journal Article
  2. 2

    Proteasome Active Sites Allosterically Regulate Each Other, Suggesting a Cyclical Bite-Chew Mechanism for Protein Breakdown by Kisselev, Alexei F, Akopian, Tatos N, Castillo, Vanesa, Goldberg, Alfred L

    Published in Molecular cell (01-09-1999)
    “…In eukaryotes, the 20S proteasome contains two chymotrypsin-like, two trypsin-like, and two active sites shown here to have caspase-like specificity. We report…”
    Get full text
    Journal Article
  3. 3

    Major Histocompatibility Complex Class I-presented Antigenic Peptides Are Degraded in Cytosolic Extracts Primarily by Thimet Oligopeptidase by Saric, Tomo, Beninga, Jochen, Graef, Claudia I., Akopian, Tatos N., Rock, Kenneth L., Goldberg, Alfred L.

    Published in The Journal of biological chemistry (28-09-2001)
    “…Nearly all peptides generated by proteasomes during protein degradation are digested rapidly to amino acids, but a few proteasomal products escape this fate…”
    Get full text
    Journal Article
  4. 4

    Range of Sizes of Peptide Products Generated during Degradation of Different Proteins by Archaeal Proteasomes by Kisselev, Alexei F., Akopian, Tatos N., Goldberg, Alfred L.

    Published in The Journal of biological chemistry (23-01-1998)
    “…The 20 S proteasome processively degrades cell proteins to peptides. Information on the sizes and nature of these products is essential for understanding the…”
    Get full text
    Journal Article
  5. 5

    Processive Degradation of Proteins and Other Catalytic Properties of the Proteasome from Thermoplasma acidophilum by Akopian, Tatos N., Kisselev, Alexei F., Goldberg, Alfred L.

    Published in The Journal of biological chemistry (17-01-1997)
    “…Although the structure of the 20 S proteasome from Thermoplasma acidophilum has been elucidated, its enzymatic properties have not been explored in depth…”
    Get full text
    Journal Article
  6. 6
  7. 7

    The Sizes of Peptides Generated from Protein by Mammalian 26 and 20 S Proteasomes by Kisselev, Alexei F., Akopian, Tatos N., Woo, Kee Min, Goldberg, Alfred L.

    Published in The Journal of biological chemistry (05-02-1999)
    “…Knowledge about the sizes of peptides generated by proteasomes during protein degradation is essential to fully understand their degradative mechanisms and the…”
    Get full text
    Journal Article
  8. 8

    The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes. Implications for understanding the degradative mechanism and antigen presentation by Kisselev, A F, Akopian, T N, Woo, K M, Goldberg, A L

    Published in The Journal of biological chemistry (05-02-1999)
    “…Knowledge about the sizes of peptides generated by proteasomes during protein degradation is essential to fully understand their degradative mechanisms and the…”
    Get full text
    Journal Article
  9. 9
  10. 10

    New insights into the mechanisms and importance of the proteasome in intracellular protein degradation by Goldberg, A L, Akopian, T N, Kisselev, A F, Lee, D H, Rohrwild, M

    Published in Biological chemistry (01-03-1997)
    “…Recent studies of the 20S proteasome from Thermoplasma acidophilum have uncovered some fundamental new properties of its catalytic mechanism. Unlike…”
    Get more information
    Journal Article