Search Results - "Akopian, Tatos N."
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Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection
Published in PLoS pathogens (01-02-2012)“…In most bacteria, Clp protease is a conserved, non-essential serine protease that regulates the response to various stresses. Mycobacteria, including…”
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Proteasome Active Sites Allosterically Regulate Each Other, Suggesting a Cyclical Bite-Chew Mechanism for Protein Breakdown
Published in Molecular cell (01-09-1999)“…In eukaryotes, the 20S proteasome contains two chymotrypsin-like, two trypsin-like, and two active sites shown here to have caspase-like specificity. We report…”
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Major Histocompatibility Complex Class I-presented Antigenic Peptides Are Degraded in Cytosolic Extracts Primarily by Thimet Oligopeptidase
Published in The Journal of biological chemistry (28-09-2001)“…Nearly all peptides generated by proteasomes during protein degradation are digested rapidly to amino acids, but a few proteasomal products escape this fate…”
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Range of Sizes of Peptide Products Generated during Degradation of Different Proteins by Archaeal Proteasomes
Published in The Journal of biological chemistry (23-01-1998)“…The 20 S proteasome processively degrades cell proteins to peptides. Information on the sizes and nature of these products is essential for understanding the…”
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Processive Degradation of Proteins and Other Catalytic Properties of the Proteasome from Thermoplasma acidophilum
Published in The Journal of biological chemistry (17-01-1997)“…Although the structure of the 20 S proteasome from Thermoplasma acidophilum has been elucidated, its enzymatic properties have not been explored in depth…”
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A novel approach to identifying β-secretase inhibitors: Bis-statine peptide mimetics discovered using structure and spot synthesis
Published in Peptides (New York, N.Y. : 1980) (01-07-2006)“…β-Secretase 1 (BACE1) is an aspartic protease believed to play a critical role in Alzheimer's disease. Inhibitors of this enzyme have been designed by…”
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The Sizes of Peptides Generated from Protein by Mammalian 26 and 20 S Proteasomes
Published in The Journal of biological chemistry (05-02-1999)“…Knowledge about the sizes of peptides generated by proteasomes during protein degradation is essential to fully understand their degradative mechanisms and the…”
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The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes. Implications for understanding the degradative mechanism and antigen presentation
Published in The Journal of biological chemistry (05-02-1999)“…Knowledge about the sizes of peptides generated by proteasomes during protein degradation is essential to fully understand their degradative mechanisms and the…”
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Protein degradation by the proteasome and dissection of its in vivo importance with synthetic inhibitors
Published in Molecular biology reports (01-03-1997)Get full text
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New insights into the mechanisms and importance of the proteasome in intracellular protein degradation
Published in Biological chemistry (01-03-1997)“…Recent studies of the 20S proteasome from Thermoplasma acidophilum have uncovered some fundamental new properties of its catalytic mechanism. Unlike…”
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