Search Results - "Akopian, Tatos N"

Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection by Raju, Ravikiran M, Unnikrishnan, Meera, Rubin, Daniel H F, Krishnamoorthy, Vidhya, Kandror, Olga, Akopian, Tatos N, Goldberg, Alfred L, Rubin, Eric J

“…In most bacteria, Clp protease is a conserved, non-essential serine protease that regulates the response to various stresses. Mycobacteria, including…”
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Proteasome Active Sites Allosterically Regulate Each Other, Suggesting a Cyclical Bite-Chew Mechanism for Protein Breakdown by Kisselev, Alexei F, Akopian, Tatos N, Castillo, Vanesa, Goldberg, Alfred L

“…In eukaryotes, the 20S proteasome contains two chymotrypsin-like, two trypsin-like, and two active sites shown here to have caspase-like specificity. We report…”
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Major Histocompatibility Complex Class I-presented Antigenic Peptides Are Degraded in Cytosolic Extracts Primarily by Thimet Oligopeptidase by Saric, Tomo, Beninga, Jochen, Graef, Claudia I., Akopian, Tatos N., Rock, Kenneth L., Goldberg, Alfred L.

“…Nearly all peptides generated by proteasomes during protein degradation are digested rapidly to amino acids, but a few proteasomal products escape this fate…”
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Range of Sizes of Peptide Products Generated during Degradation of Different Proteins by Archaeal Proteasomes by Kisselev, Alexei F., Akopian, Tatos N., Goldberg, Alfred L.

“…The 20 S proteasome processively degrades cell proteins to peptides. Information on the sizes and nature of these products is essential for understanding the…”
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Processive Degradation of Proteins and Other Catalytic Properties of the Proteasome from Thermoplasma acidophilum by Akopian, Tatos N., Kisselev, Alexei F., Goldberg, Alfred L.

“…Although the structure of the 20 S proteasome from Thermoplasma acidophilum has been elucidated, its enzymatic properties have not been explored in depth…”
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A novel approach to identifying β-secretase inhibitors: Bis-statine peptide mimetics discovered using structure and spot synthesis by Bridges, Kristie Grove, Chopra, Rajiv, Lin, Laura, Svenson, Kristine, Tam, Amy, Jin, Guixian, Cowling, Rebecca, Lovering, Frank, Akopian, Tatos N., DiBlasio-Smith, Elizabeth, Annis-Freeman, Bethany, Marvell, Tod H., LaVallie, Edward R., Zollner, Richard S., Bard, Jonathan, Somers, William S., Stahl, Mark L., Kriz, Ronald W.

“…β-Secretase 1 (BACE1) is an aspartic protease believed to play a critical role in Alzheimer's disease. Inhibitors of this enzyme have been designed by…”
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The Sizes of Peptides Generated from Protein by Mammalian 26 and 20 S Proteasomes by Kisselev, Alexei F., Akopian, Tatos N., Woo, Kee Min, Goldberg, Alfred L.

“…Knowledge about the sizes of peptides generated by proteasomes during protein degradation is essential to fully understand their degradative mechanisms and the…”
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The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes. Implications for understanding the degradative mechanism and antigen presentation by Kisselev, A F, Akopian, T N, Woo, K M, Goldberg, A L

“…Knowledge about the sizes of peptides generated by proteasomes during protein degradation is essential to fully understand their degradative mechanisms and the…”
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Protein degradation by the proteasome and dissection of its in vivo importance with synthetic inhibitors by Goldberg, A L, Akopian, T N, Kisselev, A F, Lee, D H

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New insights into the mechanisms and importance of the proteasome in intracellular protein degradation by Goldberg, A L, Akopian, T N, Kisselev, A F, Lee, D H, Rohrwild, M

“…Recent studies of the 20S proteasome from Thermoplasma acidophilum have uncovered some fundamental new properties of its catalytic mechanism. Unlike…”
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