Search Results - "Akopian, T N"

The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes. Implications for understanding the degradative mechanism and antigen presentation by Kisselev, A F, Akopian, T N, Woo, K M, Goldberg, A L

“…Knowledge about the sizes of peptides generated by proteasomes during protein degradation is essential to fully understand their degradative mechanisms and the…”
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Proteasome Active Sites Allosterically Regulate Each Other, Suggesting a Cyclical Bite-Chew Mechanism for Protein Breakdown by Kisselev, Alexei F, Akopian, Tatos N, Castillo, Vanesa, Goldberg, Alfred L

“…In eukaryotes, the 20S proteasome contains two chymotrypsin-like, two trypsin-like, and two active sites shown here to have caspase-like specificity. We report…”
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Major Histocompatibility Complex Class I-presented Antigenic Peptides Are Degraded in Cytosolic Extracts Primarily by Thimet Oligopeptidase by Saric, Tomo, Beninga, Jochen, Graef, Claudia I., Akopian, Tatos N., Rock, Kenneth L., Goldberg, Alfred L.

“…Nearly all peptides generated by proteasomes during protein degradation are digested rapidly to amino acids, but a few proteasomal products escape this fate…”
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Range of Sizes of Peptide Products Generated during Degradation of Different Proteins by Archaeal Proteasomes by Kisselev, Alexei F., Akopian, Tatos N., Goldberg, Alfred L.

“…The 20 S proteasome processively degrades cell proteins to peptides. Information on the sizes and nature of these products is essential for understanding the…”
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Processive Degradation of Proteins and Other Catalytic Properties of the Proteasome from Thermoplasma acidophilum by Akopian, Tatos N., Kisselev, Alexei F., Goldberg, Alfred L.

“…Although the structure of the 20 S proteasome from Thermoplasma acidophilum has been elucidated, its enzymatic properties have not been explored in depth…”
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New insights into the mechanisms and importance of the proteasome in intracellular protein degradation by Goldberg, A L, Akopian, T N, Kisselev, A F, Lee, D H, Rohrwild, M

“…Recent studies of the 20S proteasome from Thermoplasma acidophilum have uncovered some fundamental new properties of its catalytic mechanism. Unlike…”
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Protein degradation by the proteasome and dissection of its in vivo importance with synthetic inhibitors by Goldberg, A L, Akopian, T N, Kisselev, A F, Lee, D H

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Glutathione disulfide inhibits degradation of substance P induced by synaptosomal plasma membranes by Akopian, T N, Arzumanian, A M, Agadzhanian, A G, Arutiunian, A A

“…The effects of phosphorylation, ribosylation of proteins and formation of protein-mixed disulfides on substance P degradation under the action of synaptosomal…”
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Synaptosomal degradation of neuropeptides by Akopian, T N, Arzumanian, A M, Agadzhanian, A G, Arutiunian, A A

“…Proteolytic conversions of some neuropeptides possessing neurotransmitter and neuromodulator properties were studied on the synaptosomal plasma membrane level…”
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Beta-cyanoalanine synthase: Its purification and basic physico-chemical properties by Akopian, T N, Goriachenkova, E V

“…A method has been developed for the purification of beta-cyano-L-alanine synthase from etiolated 10-day-old seedlings of blue lupine. High purity preparations…”
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Isoenzyme composition of cathepsin D from bovine hypothalamus by Barchudrian, N A, Akopian, T N, Galoian, A A

“…The isoenzyme composition of cathepsin D from bovine hypothalamus was studied by isoelectric focusing. It was found that the soluble fraction of hypothalamic…”
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Level of peptides in blood serum in experimental traumatic illness by Safarian, Z S, Piloian, A G, Oganisian, A I, Akopian, T N

“…A procedure, developed for quantitative estimation of peptides in protein free blood serum, involved registration of products formed after reaction of peptide…”
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Activity of proteolytic enzymes and their inhibitors in experimental myocardial ischemia by Karapetian, R G, Oganesian, S S, Akopian, T N, Dzhanpoladian, E G

“…Proteolytic activity and activity of endogenous inhibitors of endopeptidases (using chymotrypsin and papain) were studied in the myocardium of rats with…”
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Protein substrates of proteinases with fluorescent labels by Kalachian, A S, Mnatsakanian, G A, Akopian, T N, Arutiunian, A A

“…Protein substrates for proteinases with double fluorescent fluorophors are synthesized. Pyridoxal-5'-phosphate, dansyl chloride and fluorescein isothiocyanate…”
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An increase in the rate of proteolysis in vitro after treatment with oxidized glutathione by Agadzhanian, A G, Arzumanian, A M, Arutiunian, A A, Kalachian, A S, Akopian, T N

“…The effect of the formation of mixed disulphides--protein-glutathione--on the proteolysis rate was studied using soluble fractions of proteins from different…”
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Breakdown of luliberin, somatostatin and substance P as an effect of hypothalamic endopeptidases by Akopian, T N, Arutiunian, A A, Laĭta, A, Galoian, A A

“…Acid and neutral proteinases were isolated with the purpose of investigating their participation in the breakdown of hypothalamic peptides and proteins. The…”
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The effect of cardioactive drugs on the proteolytic activity of the rat heart muscle by Karapetian, R G, Akopian, T N, Oganisian, A I, Oganesian, S S

“…Cardioactive drugs--beta-adrenoblocking agents (propranolol, trasicor and cordanum) and Ca2(+)-antagonists (nifedipine and phenoptine)--exhibited both…”
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Multiple forms of cathepsin D from the human brain by Barkhudarian, N A, Azarian, A V, Akopian, T N, Buniatian, G Kh

“…Six peaks of the endopeptidase activity at pH 3.2 were obtained after isoelectric focusing of soluble fractions of cortex and hypothalamus of the human brain…”
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Determination of the interaction of polycyclic hydrocarbons with proteins by the chemiluminescent method by Zakarian, A E, Akopian, T N, Panosian, G A

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Dansyl-hemoglobin as a substrate for the determination of endopeptidase activity by Azarian, A V, Akopian, T N, Arutiunian, A A

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