Low incidence of acute rejection within 6 months of kidney transplantation in HIV‐infected recipients treated with raltegravir: the Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS) 153 TREVE trial

Objectives High rates of clinical acute rejection after kidney transplantation have been reported in people living with HIV (PLHIV), probably as a consequence of drug interactions. We therefore investigated the incidence of acute rejection within 6 months of transplantation in HIV‐infected recipient...

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Published in:	HIV medicine Vol. 20; no. 3; pp. 202 - 213
Main Authors:	Matignon, M, Lelièvre, J‐D, Lahiani, A, Abbassi, K, Desvaux, D, Diallo, A, Peraldi, M‐N, Taburet, A‐M, Saillard, J, Delaugerre, C, Costagliola, D, Assoumou, L, Grimbert, P, Chesnel, Chrystel, Dumont, Cécile, Molina, Jean‐Michel, Ponscarme, Diane, Parlier, Sylvie, Loze, Bénédicte, Zucman, David, Bornarel, Dominique, Goujard, Cécile, Bourdic, Katia, Duvivier, Claudine, Shoai‐Tehrani, Michka, Touam, Fatima, Boucly, Ségolène, Maignan, Aline, Marchou, Bruno, Chauveau, Marine, Balsarin, Florence, Lagarrigue, Sandra, Raffi, François, Hüe, Hervé, Brosseau, Delphine, Pialoux, Gilles, Slama, Laurence, Adda, Anne, Verdon, Renaud, Bouvet, Elisabeth, Louis, Bernard, Nau, Pascale, Didier, Agnès, Aït Sahlia, Nawelle, Pairière, Monique, Jullien, Virginie, François, Véronique, Langner, Nathalie, Genet, Maïté, Tricot, Leila, Herel, Canan, Leroux, Nathanael, Durrbach, Antoine, Hallier, Isabelle, Legaud, Marie‐Thérèse, Legendre, Christophe, Halley, Marie‐Noëlle, Marie, Bouliet, Rostaing, Lionel, Kamar, Nassim, Beq, Audrey, Dantal, Jacques, Lemauft, Jean‐Xavier, Lerat, Lydie, Kerandel, Celine, Poulet, Myriam, Rondeau, Eric, Richard, Martine, Ravato, Sylviane, Hurault de Ligny, Bruno, Ouethrani, Mohamed, Randoux, Christine, Vkrtovsnik, François, Sedrati, Nadia, Lebranchu, Yvon, Pilorge, Bernadette, Yadel, Samia, Mohand, Hassiba Ait, Ako, Josiane, Rodrigues, Serge, Génin, Michèle, Gibowski, Severine, Le Mestre, Soizic, Gelley, Ambre, Couffin‐Cadiergues, Sandrine, Petrov‐Sanchez, Ventzislava, Delfraissy, Jean‐François, Dabis, François
Format:	Journal Article
Language:	English
Published:	England Wiley 01-03-2019
Subjects:	Adult Anti-HIV Agents - administration & dosage Anti-HIV Agents - therapeutic use Bacteriology end‐stage kidney disease Female Graft Rejection - epidemiology HIV HIV Infections - complications HIV Infections - drug therapy HIV Infections - virology HIV-1 - drug effects HIV‐associated nephropathy Human health and pathology Humans Incidence Infectious diseases Kidney Transplantation Life Sciences Male Microbiology and Parasitology Middle Aged Prospective Studies raltegravir Raltegravir Potassium - administration & dosage Raltegravir Potassium - therapeutic use Viral Load Virology HIV-associated nephropathy raltegravir end-stage kidney disease HIV kidney transplantation
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Summary:	Objectives High rates of clinical acute rejection after kidney transplantation have been reported in people living with HIV (PLHIV), probably as a consequence of drug interactions. We therefore investigated the incidence of acute rejection within 6 months of transplantation in HIV‐infected recipients treated with a protease‐inhibitor‐free raltegravir‐based regimen. Methods The Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS) 153 TREVE (NCT01453192) study was a prospective multicentre single‐arm trial in adult PLHIV awaiting kidney transplantation, with viral load < 50 HIV‐1 RNA copies/mL, CD4 T‐cell count > 200 cells/μL, and HIV‐1 strains sensitive to raltegravir, aiming to demonstrate 6‐month clinical acute rejection rates < 30%. Time to transplantation was compared with that for uninfected subjects matched for age, sex and registration date. Results In total, 61 participants were enrolled in the study, and 26 underwent kidney transplantation. Two participants experienced clinical acute rejection, corresponding to an estimated clinical acute rejection rate of 8% [95% confidence interval (CI) 2–24%] at 6 and 12 months post‐transplantation. HIV infection remained under control in all but one participant, who temporarily stopped antiretroviral treatment. Median time to transplantation was longer in PLHIV than in controls (4.3 versus 2.8 years, respectively; P = 0.002) and was not influenced by blood group. Conclusions Acute rejection rates were low after kidney transplantation in PLHIV treated with a raltegravir‐based regimen. However, PLHIV have poorer access to transplantation than HIV‐uninfected individuals after registration on the waiting list.
ISSN:	1464-2662 1468-1293
DOI:	10.1111/hiv.12700