G241R and K469E polymorphisms of intercellular adhesion molecule 1 (ICAM-1) could predispose to Hashimoto thyroiditis

This study examined firstly the possible association of G241R and K469E single nucleotide polymorphisms (SNPs) of ICAM - 1 gene with the occurrence of Hashimoto thyroiditis (HT). G241R and K469E SNPs in DNA from peripheral blood leukocytes of 190 HT and 247 healthy controls were investigated by real...

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Bibliographic Details
Published in:	Molecular biology reports Vol. 39; no. 12; pp. 10723 - 10729
Main Authors:	Akman, Fevziye Emin, Kanmaz-Özer, Müge, Vural, Pervin, Özderya, Ayşenur, Karadağ, Berrin, Doğru-Abbasoğlu, Semra, Uysal, Müjdat
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer Netherlands 01-12-2012 Springer Nature B.V
Subjects:	Adolescent Adult Aged Amino Acid Substitution - genetics Animal Anatomy Animal Biochemistry Autoimmune diseases Biomedical and Life Sciences Case-Control Studies Female Gene Frequency - genetics Genetic Predisposition to Disease Genotype & phenotype Hashimoto Disease - blood Hashimoto Disease - genetics Histology Humans Intercellular Adhesion Molecule-1 - blood Intercellular Adhesion Molecule-1 - genetics Life Sciences Lipids - blood Male Middle Aged Molecular biology Morphology Polymorphism Polymorphism, Single Nucleotide - genetics Risk factors Thyroid diseases Thyroid Hormones - blood Young Adult Endothelial dysfunction Autoimmune Intercellular adhesion molecule 1 Hashimoto thyroiditis Polymorphism
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Summary:	This study examined firstly the possible association of G241R and K469E single nucleotide polymorphisms (SNPs) of ICAM - 1 gene with the occurrence of Hashimoto thyroiditis (HT). G241R and K469E SNPs in DNA from peripheral blood leukocytes of 190 HT and 247 healthy controls were investigated by real-time PCR combined with melting curve analysis using fluorescence-labeled hybridization probes. There was a significant increase of ICAM - 1 241R allele frequency in patients with HT compared with healthy controls ( P = 0.04, OR = 1.84, 95 % CI = 1.00–3.37). Regarding ICAM - 1 K469E polymorphism, patients homozygous for E allele had 1.73–fold increased risk for developing HT according to KK homozygotes ( P = 0.04, 95 % CI = 1.00–3.01). The 469E allele frequency was higher in HT patients according to controls, however the difference was at borderline significance ( P = 0.05, OR = 1.30, 95 % CI = 1.00–1.70). No associations between polymorphisms and HT phenotypes were observed. We suggest that the G241R and K469E SNPs of ICAM - 1 gene may be related to occurrence of HT. However, more studies with larger sample size including other loci of the ICAM - 1 gene are necessary to support our findings before any definite statement can be made about the relationship between HT and ICAM - 1 polymorphism.
ISSN:	0301-4851 1573-4978
DOI:	10.1007/s11033-012-1963-7