Search Results - "Akmačić, Irena Trbojević"

Association of Systemic Lupus Erythematosus With Decreased Immunosuppressive Potential of the IgG Glycome by Vučković, Frano, Krištić, Jasminka, Gudelj, Ivan, Teruel, Maria, Keser, Toma, Pezer, Marija, Pučić‐Baković, Maja, Štambuk, Jerko, Trbojević‐Akmačić, Irena, Barrios, Clara, Pavić, Tamara, Menni, Cristina, Wang, Youxin, Zhou, Yong, Cui, Liufu, Song, Haicheng, Zeng, Qiang, Guo, Xiuhua, Pons‐Estel, Bernardo A., McKeigue, Paul, Leslie Patrick, Alan, Gornik, Olga, Spector, Tim D., Harjaček, Miroslav, Alarcon‐Riquelme, Marta, Molokhia, Mariam, Wang, Wei, Lauc, Gordan

“…Objective Glycans attached to the Fc portion of IgG are important modulators of IgG effector functions. Interindividual differences in IgG glycome composition…”
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SARS-CoV-2 S glycoprotein binding to multiple host receptors enables cell entry and infection by Trbojević-Akmačić, Irena, Petrović, Tea, Lauc, Gordan

“…The severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) infection displays a wide array of clinical manifestations. Although some risk factors…”
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High‐throughput immunoaffinity enrichment and N‐glycan analysis of human plasma haptoglobin by Šimunović, Jelena, Gašperšič, Jernej, Černigoj, Urh, Vidič, Jana, Štrancar, Aleš, Novokmet, Mislav, Razdorov, Genadij, Pezer, Marija, Lauc, Gordan, Trbojević‐Akmačić, Irena

“…Haptoglobin (Hp) is a positive acute phase protein, synthesized in the liver, with four N‐glycosylation sites carrying mainly complex type N‐glycans. Its…”
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Genetic regulation of post-translational modification of two distinct proteins by Landini, Arianna, Trbojević-Akmačić, Irena, Navarro, Pau, Tsepilov, Yakov A., Sharapov, Sodbo Z., Vučković, Frano, Polašek, Ozren, Hayward, Caroline, Petrović, Tea, Vilaj, Marija, Aulchenko, Yurii S., Lauc, Gordan, Wilson, James F., Klarić, Lucija

“…Post-translational modifications diversify protein functions and dynamically coordinate their signalling networks, influencing most aspects of cell physiology…”
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Glycosylation Profile of Immunoglobulin G Is Cross-Sectionally Associated With Cardiovascular Disease Risk Score and Subclinical Atherosclerosis in Two Independent Cohorts by Menni, Cristina, Gudelj, Ivan, Macdonald-Dunlop, Erin, Mangino, Massimo, Zierer, Jonas, Bešić, Erim, Joshi, Peter K, Trbojević-Akmačić, Irena, Chowienczyk, Phil J, Spector, Tim D, Wilson, James F, Lauc, Gordan, Valdes, Ana M

“…RATIONALE:One measure of protein glycosylation (GlycA) has been reported to predict higher cardiovascular risk by reflecting inflammatory pathways…”
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N-Glycan Profile and Kidney Disease in Type 1 Diabetes by Bermingham, Mairead L, Colombo, Marco, McGurnaghan, Stuart J, Blackbourn, Luke A K, Vučković, Frano, Pučić Baković, Maja, Trbojević-Akmačić, Irena, Lauc, Gordan, Agakov, Felix, Agakova, Anna S, Hayward, Caroline, Klarić, Lucija, Palmer, Colin N A, Petrie, John R, Chalmers, John, Collier, Andrew, Green, Fiona, Lindsay, Robert S, Macrury, Sandra, McKnight, John A, Patrick, Alan W, Thekkepat, Sandeep, Gornik, Olga, McKeigue, Paul M, Colhoun, Helen M

“…Poorer glycemic control in type 1 diabetes may alter N-glycosylation patterns on circulating glycoproteins, and these alterations may be linked with diabetic…”
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High-throughput Serum N-Glycomics: Method Comparison and Application to Study Rheumatoid Arthritis and Pregnancy-associated Changes[S] by Reiding, Karli R., Bondt, Albert, Hennig, René, Gardner, Richard A., O'Flaherty, Roisin, Trbojević-Akmačić, Irena, Shubhakar, Archana, Hazes, Johanna M.W., Reichl, Udo, Fernandes, Daryl L., Pučić-Baković, Maja, Rapp, Erdmann, Spencer, Daniel I.R., Dolhain, Radboud J.E.M., Rudd, Pauline M., Lauc, Gordan, Wuhrer, Manfred

“…N-Glycosylation is a fundamentally important protein modification with a major impact on glycoprotein characteristics such as serum half-life and receptor…”
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Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation by Shen, Xia, Klarić, Lucija, Sharapov, Sodbo, Mangino, Massimo, Ning, Zheng, Wu, Di, Trbojević-Akmačić, Irena, Pučić-Baković, Maja, Rudan, Igor, Polašek, Ozren, Hayward, Caroline, Spector, Timothy D., Wilson, James F., Lauc, Gordan, Aulchenko, Yurii S.

“…Joint modeling of a number of phenotypes using multivariate methods has often been neglected in genome-wide association studies and if used, replication has…”
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The sweet spot for biologics: recent advances in characterization of biotherapeutic glycoproteins by O'Flaherty, Róisín, Trbojević-Akmačić, Irena, Greville, Gordon, Rudd, Pauline M, Lauc, Gordan

“…Glycosylation is recognized as a Critical Quality Attribute for therapeutic glycoproteins such as monoclonal antibodies, fusion proteins and therapeutic…”
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Plasma N-glycans in colorectal cancer risk by Doherty, Margaret, Theodoratou, Evropi, Walsh, Ian, Adamczyk, Barbara, Stöckmann, Henning, Agakov, Felix, Timofeeva, Maria, Trbojević-Akmačić, Irena, Vučković, Frano, Duffy, Fergal, McManus, Ciara A., Farrington, Susan M., Dunlop, Malcolm G., Perola, Markus, Lauc, Gordan, Campbell, Harry, Rudd, Pauline M.

“…Aberrant glycosylation has been associated with a number of diseases including cancer. Our aim was to elucidate changes in whole plasma N -glycosylation…”
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High throughput profiling of whole plasma N-glycans in type II diabetes mellitus patients and healthy individuals: A perspective from a Ghanaian population by Adua, Eric, Memarian, Elham, Russell, Alyce, Trbojević-Akmačić, Irena, Gudelj, Ivan, Jurić, Julija, Roberts, Peter, Lauc, Gordan, Wang, Wei

“…Aberrant protein glycosylation may reflect changes in cell metabolism of type II diabetes mellitus (T2DM) and offers fresh vistas for discovering potential…”
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Heritability of Human Plasma N‑Glycome by Zaytseva, Olga O, Freidin, Maxim B, Keser, Toma, Štambuk, Jerko, Ugrina, Ivo, Šimurina, Mirna, Vilaj, Marija, Štambuk, Tamara, Trbojević-Akmačić, Irena, Pučić-Baković, Maja, Lauc, Gordan, Williams, Frances M. K, Novokmet, Mislav

“…The N-glycosylation profile of total human plasma proteins could be a useful biomarker for various pathological states. Reliable high-throughput methods for…”
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High-throughput analysis of immunoglobulin G glycosylation by Trbojević-Akmačić, Irena, Vilaj, Marija, Lauc, Gordan

“…Glycosylation of immunoglobulin G (IgG) is important for its effector functions and was shown to be related to age, sex and disease status of an individual…”
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Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns by Wahl, Annika, van den Akker, Erik, Klaric, Lucija, Štambuk, Jerko, Benedetti, Elisa, Plomp, Rosina, Razdorov, Genadij, Trbojević-Akmačić, Irena, Deelen, Joris, van Heemst, Diana, Slagboom, P Eline, Vučković, Frano, Grallert, Harald, Krumsiek, Jan, Strauch, Konstantin, Peters, Annette, Meitinger, Thomas, Hayward, Caroline, Wuhrer, Manfred, Beekman, Marian, Lauc, Gordan, Gieger, Christian

“…Immunoglobulin G (IgG), a glycoprotein secreted by plasma B-cells, plays a major role in the human adaptive immune response and are associated with a wide…”
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Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway by Benedetti, Elisa, Pučić-Baković, Maja, Keser, Toma, Wahl, Annika, Hassinen, Antti, Yang, Jeong-Yeh, Liu, Lin, Trbojević-Akmačić, Irena, Razdorov, Genadij, Štambuk, Jerko, Klarić, Lucija, Ugrina, Ivo, Selman, Maurice H. J., Wuhrer, Manfred, Rudan, Igor, Polasek, Ozren, Hayward, Caroline, Grallert, Harald, Strauch, Konstantin, Peters, Annette, Meitinger, Thomas, Gieger, Christian, Vilaj, Marija, Boons, Geert-Jan, Moremen, Kelley W., Ovchinnikova, Tatiana, Bovin, Nicolai, Kellokumpu, Sakari, Theis, Fabian J., Lauc, Gordan, Krumsiek, Jan

“…Immunoglobulin G (IgG) is a major effector molecule of the human immune response, and aberrations in IgG glycosylation are linked to various diseases. However,…”
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Total serum N-glycans associate with response to immune checkpoint inhibition therapy and survival in patients with advanced melanoma by Visconti, Alessia, Rossi, Niccolò, Deriš, Helena, Lee, Karla A, Hanić, Maja, Trbojević-Akmačić, Irena, Thomas, Andrew M, Bolte, Laura A, Björk, Johannes R, Hooiveld-Noeken, Jahlisa S, Board, Ruth, Harland, Mark, Newton-Bishop, Julia, Harries, Mark, Sacco, Joseph J, Lorigan, Paul, Shaw, Heather M, de Vries, Elisabeth G E, Fehrmann, Rudolf S N, Weersma, Rinse K, Spector, Tim D, Nathan, Paul, Hospers, Geke A P, Sasieni, Peter, Bataille, Veronique, Lauc, Gordan, Falchi, Mario

“…Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of melanoma and other cancers. However, no reliable biomarker of survival or response has…”
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Semi‐high‐throughput isolation and N‐glycan analysis of human fibrinogen using monolithic supports bearing monoclonal anti‐human fibrinogen antibodies by Vidic, Urška, Trbojević‐Akmačić, Irena, Černigoj, Urh, Albers, Malena, Gašperšič, Jernej, Pučić‐Baković, Maja, Vidič, Jana, Štrancar, Aleš, Lauc, Gordan

“…Fibrinogen (FIB) is a secretory glycoprotein synthesized by hepatocytes that has a key role in blood clotting. Its glycosylation has not been studied in detail…”
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IgG N-glycome changes during the course of severe COVID-19: An observational study by Petrović, Tea, Vijay, Amrita, Vučković, Frano, Trbojević-Akmačić, Irena, Ollivere, Benjamin J, Marjanović, Damir, Bego, Tamer, Prnjavorac, Besim, Đerek, Lovorka, Markotić, Alemka, Lukšić, Ivica, Jurin, Ivana, Valdes, Ana M, Hadžibegović, Irzal, Lauc, Gordan

“…The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes a respiratory illness named coronavirus disease 2019 (COVID-19), which is one of the…”
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Immunoglobulin G glycome composition in transition from premenopause to postmenopause by Deriš, Helena, Kifer, Domagoj, Cindrić, Ana, Petrović, Tea, Cvetko, Ana, Trbojević-Akmačić, Irena, Kolčić, Ivana, Polašek, Ozren, Newson, Louise, Spector, Tim, Menni, Cristina, Lauc, Gordan

“…Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms…”
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Anti-TNF Biologicals Enhance the Anti-Inflammatory Properties of IgG N-Glycome in Crohn's Disease by Hanić, Maja, Vučković, Frano, Deriš, Helena, Bewshea, Claire, Lin, Simeng, Goodhand, James R, Ahmad, Tariq, Trbojević-Akmačić, Irena, Kennedy, Nicholas A, Lauc, Gordan

“…Crohn's disease (CD) is a chronic inflammation of the digestive tract that significantly impairs patients' quality of life and well-being. Anti-TNF biologicals…”
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