Search Results - "Aklillu, Eleni"

Global Tuberculosis Report 2020 – Reflections on the Global TB burden, treatment and prevention efforts by Chakaya, Jeremiah, Khan, Mishal, Ntoumi, Francine, Aklillu, Eleni, Fatima, Razia, Mwaba, Peter, Kapata, Nathan, Mfinanga, Sayoki, Hasnain, Seyed Ehtesham, Katoto, Patrick D.M.C., Bulabula, André N.H., Sam-Agudu, Nadia A., Nachega, Jean B., Tiberi, Simon, McHugh, Timothy D., Abubakar, Ibrahim, Zumla, Alimuddin

“…•In 2020, COVID-19 dislodged TB as the top infectious disease cause of mortality globally.•Globally, an estimated 10.0 million people developed active TB…”
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Efficacy and safety of praziquantel and dihydroartemisinin piperaquine combination for treatment and control of intestinal schistosomiasis: A randomized, non-inferiority clinical trial by Mnkugwe, Rajabu Hussein, Minzi, Omary, Kinung'hi, Safari, Kamuhabwa, Appolinary, Aklillu, Eleni

“…Background Despite the reported success in reducing morbidity, praziquantel alone is insufficient for the control and elimination of schistosomiasis, partly…”
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Correlation of N-acetyltransferase 2 genotype and acetylation status with plasma isoniazid concentration and its metabolic ratio in ethiopian tuberculosis patients by Sileshi, Tesemma, Telele, Nigus Fikrie, Burkley, Victoria, Makonnen, Eyasu, Aklillu, Eleni

“…Unfavorable treatment outcomes for tuberculosis (TB) treatment might result from altered plasma exposure to antitubercular drugs in TB patients. The present…”
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Prevalence and correlates of intestinal schistosomiasis infection among school-aged children in North-Western Tanzania by Mnkugwe, Rajabu Hussein, Minzi, Omary S, Kinung'hi, Safari M, Kamuhabwa, Appolinary A, Aklillu, Eleni

“…Schistosomiasis is a neglected tropical disease that continues to cause morbidity and mortality in Sub Saharan Africa. Due to its endemicity, co-infection with…”
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Constitutive androstane receptor and pregnane X receptor genotype influence efavirenz plasma concentration and CYP2B6 enzyme activity by Petros, Zelalem, Habtewold, Abiy, Makonnen, Eyasu, Aklillu, Eleni

“…Efavirenz is metabolized by CYP2B6, an inducible enzyme whose expression is regulated by the constitutive androstane receptor and pregnane X receptor nuclear…”
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The safety of a dolutegravir (DTG)-based antiretroviral treatment (ART) regimen for pregnancy and birth outcomes in Ethiopia: evidence from multicenter cohort study by Gedefaw, Abel, Tadesse, Birkneh Tilahun, Berhan, Yifru, Makonnen, Eyasu, Vella, Stefano, Aklillu, Eleni

“…A dolutegravir (DTG)-based antiretroviral regimen has been rolled out for pregnant women in low- and middle-income countries since 2020. However, available…”
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Optimal single sampling time-point for monitoring of praziquantel exposure in children by Mnkugwe, Rajabu Hussein, Ngaimisi Kitabi, Eliford, Kinung’hi, Safari, Kamuhabwa, Appolinary A. R., Minzi, Omary Mashiku, Aklillu, Eleni

“…Praziquantel pharmacokinetics studies in schistosomiasis infected children are scarce partly due to the challenges/complexity of intensive blood sampling in…”
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Prevalence and predictors of glucose metabolism disorders among People Living with HIV on combination antiretroviral therapy by Tadesse, Wondmagegn Tamiru, Adankie, Birhanemeskel T, Shibeshi, Workineh, Amogne, Wondwossen, Aklillu, Eleni, Engidawork, Ephrem

“…We investigated prevalence and predictors of glucose metabolism disorders (GMDs) among People Living with HIV (PLWH) on efavirenz- and…”
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Potential drug–drug interactions between antiretroviral therapy and treatment regimens for multi-drug resistant tuberculosis: Implications for HIV care of MDR-TB co-infected individuals by Mukonzo, Jackson, Aklillu, Eleni, Marconi, Vincent, Schinazi, Raymond F.

“…•MDR-TB agents exhibit overlapping enzyme inhibition that might affect ART outcomes.•Clofazimine, a core MDR-TB drug, could be responsible for most DDIs with…”
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Effect of pharmacogenetic variations on praziquantel plasma concentration and safety outcomes among school children in Rwanda by Barry, Abbie, Kabatende, Joseph, Telele, Nigus Fikrie, Mnkugwe, Rajabu Hussein, Mugisha, Michael, Ntirenganya, Lazare, Bienvenu, Emile, Aklillu, Eleni

“…School-based mass drug administration (MDA) of Praziquantel (PZQ) is the global intervention strategy for elimination of schistosomiasis. Genetic variations in…”
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CYP2C19 and CYP2J2 genotypes predict praziquantel plasma exposure among Ethiopian school-aged children by Gebreyesus, Tigist Dires, Makonnen, Eyasu, Telele, Nigus Fikrie, Barry, Abbie, Mnkugwe, Rajabu Hussein, Gerba, Heran, Dahl, Marja-Liisa, Aklillu, Eleni

“…Metabolism of praziquantel (PZQ), a racemic mixture and the only drug approved to treat S. mansoni infection, is mediated by genetically polymorphic enzymes…”
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Pregnancy Increases CYP3A Enzymes Activity as Measured by the 4β-Hydroxycholesterol/Cholesterol Ratio by Mlugu, Eulambius M, Minzi, Omary M, Kamuhabwa, Appolinary A R, Diczfalusy, Ulf, Aklillu, Eleni

“…Changes in cortisol and other hormones during pregnancy may alter CYP3A enzymes activity, but data from sub-Saharan Africa are sparse. We investigated the…”
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Importance of ethnicity, CYP2B6 and ABCB1 genotype for efavirenz pharmacokinetics and treatment outcomes: a parallel-group prospective cohort study in two sub-Saharan Africa populations by Ngaimisi, Eliford, Habtewold, Abiy, Minzi, Omary, Makonnen, Eyasu, Mugusi, Sabina, Amogne, Wondwossen, Yimer, Getnet, Riedel, Klaus-Dieter, Janabi, Mohammed, Aderaye, Getachew, Mugusi, Ferdinand, Bertilsson, Leif, Aklillu, Eleni, Burhenne, Juergen

“…We evaluated the importance of ethnicity and pharmacogenetic variations in determining efavirenz pharmacokinetics, auto-induction and immunological outcomes in…”
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Effect of Pharmacogenetics Variations on Praziquantel Plasma Concentrations and Schistosomiasis Treatment Outcomes Among Infected School-Aged Children in Tanzania by Mnkugwe, Rajabu Hussein, Minzi, Omary, Kinung’hi, Safari, Kamuhabwa, Appolinary, Aklillu, Eleni

“…Studies on pharmacogenetics of praziquantel (PZQ) and its relevance on plasma drug concentrations and schistosomiasis treatment outcomes are lacking. We…”
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Screening for latent tuberculosis in migrants—status quo and future challenges by Petersen, Eskild, Al-Abri, Seif, Al-Jardani, Amina, Memish, Ziad A., Aklillu, Eleni, Ntoumi, Francine, Mwaba, Peter, Wejse, Christian, Zumla, Alimuddin, Al-Yaquobi, Fatma

“…•Latent tuberculosis infection (LTBI) is key to fulfilling the WHO “End tuberculosis” strategy by 2035.•This review summarizes existing data on screening and…”
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High Gastrointestinal Colonization Rate with Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in Hospitalized Patients: Emergence of Carbapenemase-Producing K. pneumoniae in Ethiopia by Desta, Kassu, Woldeamanuel, Yimtubezinash, Azazh, Aklilu, Mohammod, Halima, Desalegn, Dawit, Shimelis, Damte, Gulilat, Dereje, Lamisso, Biruk, Makonnen, Eyasu, Worku, Alemayehu, Mannerqvist, Kerstin, Struwe, Johan, Aspevall, Olov, Aklillu, Eleni

“…We investigated the gastrointestinal colonization rate and antibiotic resistance patterns of Extended-Spectrum Beta-Lactamase (ESBL)- producing Escherichia…”
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Blue Skies research is essential for ending the Tuberculosis pandemic and advancing a personalized medicine approach for holistic management of Respiratory Tract infections by Ntoumi, Francine, Petersen, Eskild, Mwaba, Peter, Aklillu, Eleni, Mfinanga, Sayoki, Yeboah-Manu, Dorothy, Maeurer, Markus, Zumla, Alimuddin

“…•‘Blue skies research’ refers to basic science or fundamental research•‘Blue skies research’ is essential new TB tools development for eradicating…”
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Efficacy and safety of praziquantel preventive chemotherapy in Schistosoma mansoni infected school children in Southern Ethiopia: A prospective cohort study by Gebreyesus, Tigist Dires, Makonnen, Eyasu, Tadele, Tafesse, Mekete, Kalkidan, Gashaw, Habtamu, Gerba, Heran, Aklillu, Eleni

“…The World Health Organization recommends efficacy and safety surveillance of anti-helminths used in mass drug administration campaigns. We evaluated the…”
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Evaluation of patterns of liver toxicity in patients on antiretroviral and anti-tuberculosis drugs: a prospective four arm observational study in ethiopian patients by Yimer, Getnet, Gry, Marcus, Amogne, Wondwossen, Makonnen, Eyasu, Habtewold, Abiy, Petros, Zelalem, Aderaye, Getachew, Schuppe-Koistinen, Ina, Lindquist, Lars, Aklillu, Eleni

“…To evaluate the incidence, type, severity and predictors of antiretroviral and/or anti-tuberculosis drugs induced liver injury (DILI). A total of 1,060…”
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Pharmacogenetic & pharmacokinetic biomarker for efavirenz based ARV and rifampicin based anti-TB drug induced liver injury in TB-HIV infected patients by Yimer, Getnet, Ueda, Nobuhisa, Habtewold, Abiy, Amogne, Wondwossen, Suda, Akira, Riedel, Klaus-Dieter, Burhenne, Jürgen, Aderaye, Getachew, Lindquist, Lars, Makonnen, Eyasu, Aklillu, Eleni

“…Implication of pharmacogenetic variations and efavirenz pharmacokinetics in concomitant efavirenz based antiviral therapy and anti-tubercular drug induced…”
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