Search Results - "Akl, W"

TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism by Alesi, Nicola, Akl, Elie W., Khabibullin, Damir, Liu, Heng-Jia, Nidhiry, Anna S., Garner, Emma R., Filippakis, Harilaos, Lam, Hilaire C., Shi, Wei, Viswanathan, Srinivas R., Morroni, Manrico, Ferguson, Shawn M., Henske, Elizabeth P.

“…Tuberous Sclerosis Complex (TSC) is caused by TSC1 or TSC2 mutations, resulting in hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1)…”
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Dynamic behavior of polyurea composites subjected to high strain rate loading by Akl, W., Ali, M., Aldraihem, O., Baz, A.

“…A comprehensive theoretical and experimental investigation is presented of the behavior of polyurea composites subjected to high strain-rate impact loading…”
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TFEB drives mTORC1 hyperactivation and kidney disease in Tuberous Sclerosis Complex by Alesi, Nicola, Khabibullin, Damir, Rosenthal, Dean M., Akl, Elie W., Cory, Pieter M., Alchoueiry, Michel, Salem, Samer, Daou, Melissa, Gibbons, William F., Chen, Jennifer A., Zhang, Long, Filippakis, Harilaos, Graciotti, Laura, Miceli, Caterina, Monfregola, Jlenia, Vilardo, Claudia, Morroni, Manrico, Di Malta, Chiara, Napolitano, Gennaro, Ballabio, Andrea, Henske, Elizabeth P.

“…Tuberous Sclerosis Complex (TSC) is caused by TSC1 or TSC2 mutations, leading to hyperactivation of mechanistic target of rapamycin complex 1 (mTORC1) and…”
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Variation in targetable genomic alterations in non-small cell lung cancer by genetic ancestry, sex, smoking history, and histology by Adib, Elio, Nassar, Amin H, Abou Alaiwi, Sarah, Groha, Stefan, Akl, Elie W, Sholl, Lynette M, Michael, Kesi S, Awad, Mark M, Jӓnne, Pasi A, Gusev, Alexander, Kwiatkowski, David J

“…Genomic alterations in 8 genes are now the targets of FDA-approved therapeutics in non-small cell lung cancer (NSCLC), but their distribution according to…”
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Energy dissipation characteristics of polyurea and polyurea/carbon black composites by Akl, W., Nouh, M., Aldraihem, O., Baz, A.

“…The energy dissipation characteristics of polyurea and polyurea/carbon black composites are determined under cycling loading at different amplitudes and…”
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Trans-ethnic variation in germline variants of patients with renal cell carcinoma by Abou Alaiwi, Sarah, Nassar, Amin H., Adib, Elio, Groha, Stefan M., Akl, Elie W., McGregor, Bradley A., Esplin, Edward D., Yang, Shan, Hatchell, Kathryn, Fusaro, Vincent, Nielsen, Sarah, Kwiatkowski, David J., Sonpavde, Guru P., Pomerantz, Mark, Garber, Judy E., Freedman, Matthew L., Rana, Huma Q., Gusev, Alexander, Choueiri, Toni K.

“…Prior studies of the renal cell carcinoma (RCC) germline landscape investigated predominantly patients of European ancestry. We examine the frequency of…”
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Topology optimization of a plate coupled with acoustic cavity by Akl, W., El-Sabbagh, A., Al-Mitani, K., Baz, A.

“…Optimization of the topology of a plate coupled with an acoustic cavity is presented in an attempt to minimize the fluid–structure interactions at different…”
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Acoustic metamaterials with circular sector cavities and programmable densities by Akl, W, Elsabbagh, A, Baz, A

“…Considerable interest has been devoted to the development of various classes of acoustic metamaterials that can control the propagation of acoustical wave…”
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Wireless and distributed sensing of the shape of morphing structures by Akl, W., Poh, S., Baz, A.

“…Monitoring the shape of morphing structures is essential for their effective and safe operation. However, current sensing systems such as fiber optic sensors…”
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Topology Optimization of Fluid-Loaded Shells by Minimizing the Acoustic Coupling to the Fluid Domain by Akl, W.

“…Topology optimization of fluid-loaded shells is presented. A finite element model with shallow shell elements is developed using strain-based formulation. The…”
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FGFR2/3 genomic alterations and response to Enfortumab Vedotin in metastatic urothelial carcinoma by Adib, Elio, El‐Zarif, Talal, Jain, Rohit K., Skelton, William P., Freeman, Dory, Curran, Catherine, Akl, Elie W., Nassar, Amin H., Ravi, Praful, Mantia, Charlene, Kwiatkowski, David J., Choueiri, Toni K., Sonpavde, Guru P.

“…Enfortumab Vedotin (EV) is approved for metastatic urothelial carcinoma (mUC) progressing post-platinum and PD1/L1 inhibitor therapy. Erdafitinib is approved…”
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Finite-element modeling of an acoustic cloak for three-dimensional flexible shells with structural excitation by Ramadan, M., Akl, W., Elnady, T., Elsabbagh, A.

“…A finite-element model for three-dimensional acoustic cloaks in both cylindrical and spherical coordinates is presented. The model is developed through…”
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Coronavirus Goes Viral: Quantifying the COVID-19 Misinformation Epidemic on Twitter by Kouzy, Ramez, Abi Jaoude, Joseph, Kraitem, Afif, El Alam, Molly B, Karam, Basil, Adib, Elio, Zarka, Jabra, Traboulsi, Cindy, Akl, Elie W, Baddour, Khalil

“…Background Since the beginning of the coronavirus disease 2019 (COVID-19) epidemic, misinformation has been spreading uninhibited over traditional and social…”
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Optimization of the static and dynamic characteristics of plates with isogrid stiffeners by Akl, W., El-Sabbagh, A., Baz, A.

“…In this paper, the orientation angles of stiffeners arranged in the form of isogrid configuration over a flat plate are selected to optimize the static and…”
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The Use of Social Media to Increase the Impact of Health Research: Systematic Review by Bardus, Marco, El Rassi, Rola, Chahrour, Mohamad, Akl, Elie W, Raslan, Abdul Sattar, Meho, Lokman I, Akl, Elie A

“…Academics in all disciplines increasingly use social media to share their publications on the internet, reaching out to different audiences. In the last few…”
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CDKN2A Alterations and Response to Immunotherapy in Solid Tumors by Adib, Elio, Nassar, Amin H, Akl, Elie W, Abou Alaiwi, Sarah, Nuzzo, Pier Vitale, Mouhieddine, Tarek H, Sonpavde, Guru, Haddad, Robert I, Mouw, Kent W, Giannakis, Marios, Hodi, F Stephen, Shukla, Sachet A, Gusev, Alexander, Braun, David A, Choueiri, Toni K, Kwiatkowski, David J

“…Immune checkpoint inhibitors (ICI) have shown clinical benefit in many types of metastatic cancers with only a few predictive biomarkers identified so far. is…”
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Ancestry-driven recalibration of tumor mutational burden and disparate clinical outcomes in response to immune checkpoint inhibitors by Nassar, Amin H., Adib, Elio, Abou Alaiwi, Sarah, El Zarif, Talal, Groha, Stefan, Akl, Elie W., Nuzzo, Pier Vitale, Mouhieddine, Tarek H., Perea-Chamblee, Tomin, Taraszka, Kodi, El-Khoury, Habib, Labban, Muhieddine, Fong, Christopher, Arora, Kanika S., Labaki, Chris, Xu, Wenxin, Sonpavde, Guru, Haddad, Robert I., Mouw, Kent W., Giannakis, Marios, Hodi, F. Stephen, Zaitlen, Noah, Schoenfeld, Adam J., Schultz, Nikolaus, Berger, Michael F., MacConaill, Laura E., Ananda, Guruprasad, Kwiatkowski, David J., Choueiri, Toni K., Schrag, Deborah, Carrot-Zhang, Jian, Gusev, Alexander

“…The immune checkpoint inhibitor (ICI) pembrolizumab is US FDA approved for treatment of solid tumors with high tumor mutational burden (TMB-high; ≥10…”
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CDH1 germline variants are enriched in patients with colorectal cancer, gastric cancer, and breast cancer by Adib, Elio, El Zarif, Talal, Nassar, Amin H., Akl, Elie W., Abou Alaiwi, Sarah, Mouhieddine, Tarek H., Esplin, Edward D., Hatchell, Kathryn, Nielsen, Sarah M., Rana, Huma Q., Choueiri, Toni K., Kwiatkowski, David J., Sonpavde, Guru

“…Background and aims CDH1 germline variants have been linked to heritability in diffuse gastric (DGC) and lobular breast cancer (LBC). Studies have not yet…”
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Active Vibration and Noise Control using Smart Foam by Akl, W., Baz, A.

“…A new class of smart foam is developed and attached to a flexible aluminum plate coupled with a rigid acoustic cavity in an attempt to evaluate its…”
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Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex by Kovalenko, Andrii, Sanin, Andres, Kosmas, Kosmas, Zhang, Long, Wang, Ji, Akl, Elie W, Giannikou, Krinio, Probst, Clemens K, Hougard, Thomas R, Rue, Ryan W, Krymskaya, Vera P, Asara, John M, Lam, Hilaire C, Kwiatkowski, David J, Henske, Elizabeth P, Filippakis, Harilaos

“…Lymphangioleiomyomatosis is a rare destructive lung disease affecting primarily women and is the primary lung manifestation of tuberous sclerosis complex…”
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