Search Results - "Akkus, Ozan"

The Mechanical Environment of Bone Marrow: A Review by Gurkan, Umut Atakan, Akkus, Ozan

“…Bone marrow is a viscous tissue that resides in the confines of bones and houses the vitally important pluripotent stem cells. Due to its confinement by bones,…”
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Mechanical Properties, Cytocompatibility and Manufacturability of Chitosan:PEGDA Hybrid-Gel Scaffolds by Stereolithography by Morris, Viola B., Nimbalkar, Siddharth, Younesi, Mousa, McClellan, Phillip, Akkus, Ozan

“…Extracellular matrix mimetic hydrogels which hybridize synthetic and natural polymers offer molecularly-tailored, bioactive properties and tunable mechanical…”
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Effects of substrate stiffness on the tenoinduction of human mesenchymal stem cells by Islam, Anowarul, Mbimba, Thomas, Younesi, Mousa, Akkus, Ozan

“…[Display omitted] Extracellular matrix modulus plays an important role in regulating cell morphology, proliferation and differentiation during regular and…”
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Tenogenic Induction of Human MSCs by Anisotropically Aligned Collagen Biotextiles by Younesi, Mousa, Islam, Anowarul, Kishore, Vipuil, Anderson, James M., Akkus, Ozan

“…A novel biofabrication modality, electrophoretic compaction with macromolecular alignment, is utilized to make collagen threads that mimic the native tendon's…”
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Tenogenic differentiation of human MSCs induced by the topography of electrochemically aligned collagen threads by Kishore, Vipuil, Bullock, Whitney, Sun, Xuanhao, Van Dyke, William Scott, Akkus, Ozan

“…Abstract Topographical cues from the extracellular microenvironment can influence cellular activity including proliferation and differentiation. Information on…”
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Modeling the Electromobility of Type-I Collagen Molecules in the Electrochemical Fabrication of Dense and Aligned Tissue Constructs by Uquillas, Jorge Alfredo, Akkus, Ozan

“…Isoelectric focusing (IEF) of type-I collagen molecules is a technology with proven efficacy to produce dense and aligned collagen-based biomaterials. The…”
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Assessing matrix quality by Raman spectroscopy helps predict fracture toughness of human cortical bone by Unal, Mustafa, Uppuganti, Sasidhar, Timur, Selin, Mahadevan-Jansen, Anita, Akkus, Ozan, Nyman, Jeffry S.

“…Developing clinical tools that assess bone matrix quality could improve the assessment of a person’s fracture risk. To determine whether Raman spectroscopy…”
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Diffuse microdamage in bone activates anabolic response by osteoblasts via involvement of voltage-gated calcium channels by Jung, Hyungjin, Akkus, Ozan

“…Introduction Matrix damage sustained by bone tissue is repaired by the concerted action of bone cells. Previous studies have reported extracellular calcium…”
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The High-cycle Fatigue Life of Cortical Bone Allografts Is Radiation Sterilization Dose-dependent: An In Vitro Study by Ina, Jason, Vakharia, Ajit, Akkus, Ozan, Rimnac, Clare M.

“…Structural cortical bone allografts are a reasonable treatment option for patients with large cortical bone defects caused by trauma, tumors, or complications…”
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The associations between mineral crystallinity and the mechanical properties of human cortical bone by Yerramshetty, Janardhan S, Akkus, Ozan

“…Abstract It is well known that the amount of mineralization renders bone its stiffness. However, besides the mere amount of the mineral phase, size and shape…”
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Effect of storage and aging conditions on the flexural strength and flexural modulus of CAD/CAM materials by PORTO, Thiago Soares, ROPERTO, Renato Cassio, AKKUS, Anna, AKKUS, Ozan, TEICH, Sorin, FADDOUL, Fady, PORTO-NETO, Sizenando Toledo, CAMPOS, Edson Alves

“…Computer-aided design/computer-aided manufacturing (CAD/CAM) materials were submitted to thermocycling, to identify changes in mechanical behavior. Four…”
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Physically Crosslinked Nanocomposites from Silicate-Crosslinked PEO: Mechanical Properties and Osteogenic Differentiation of Human Mesenchymal Stem Cells by Gaharwar, Akhilesh K., Kishore, Vipuil, Rivera, Christian, Bullock, Whitney, Wu, Chia-Jung, Akkus, Ozan, Schmidt, Gudrun

“…The mechanical and biological properties of silicate‐crosslinked PEO nanocomposites are studied. A strong correlation is observed between silicate…”
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Age-related changes in physicochemical properties of mineral crystals are related to impaired mechanical function of cortical bone by Akkus, Ozan, Adar, Fran, Schaffler, Mitchell B.

“…The measures of bone mass and architecture need to be supplemented with physicochemical and compositional measures for better assessment of fracture risk. In…”
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Mesenchymal Stem Cell Delivery via Topographically Tenoinductive Collagen Biotextile Enhances Regeneration of Segmental Tendon Defects by McClellan, Phillip, Ina, Jason G., Knapik, Derrick M., Isali, Ilaha, Learn, Greg, Valente, Alexis, Wen, Yujing, Wen, Ruiqi, Anderson, James M., Gillespie, Robert J., Akkus, Ozan

“…Background: Successful management of massive rotator cuff (RC) tendon tears represents a treatment challenge because of the limited intrinsic healing capacity…”
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Genipin crosslinking elevates the strength of electrochemically aligned collagen to the level of tendons by Alfredo Uquillas, Jorge, Kishore, Vipuil, Akkus, Ozan

“…Collagen-based tissue mimics are important in clinical research because collagen is the main structural element in tendons. The current study aimed to improve…”
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Fabrication of compositionally and topographically complex robust tissue forms by 3D-electrochemical compaction of collagen by Younesi, Mousa, Islam, Anowarul, Kishore, Vipuil, Panit, Stefi, Akkus, Ozan

“…Collagen solutions are phase-transformed to mechanically robust shell structures with curviplanar topographies using electrochemically-induced pH gradients…”
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An electrochemical fabrication process for the assembly of anisotropically oriented collagen bundles by Cheng, Xingguo, Gurkan, Umut A, Dehen, Christopher J, Tate, Michael P, Hillhouse, Hugh W, Simpson, Garth J, Akkus, Ozan

“…Abstract Controlled assembly of collagen molecules in vitro remains a major challenge for fabricating the next generation of engineered tissues. Here we…”
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Effects of losartan treatment on the physicochemical properties of diabetic rat bone by Donmez, Baris Ozgur, Unal, Mustafa, Ozdemir, Semir, Ozturk, Nihal, Oguz, Nurettin, Akkus, Ozan

“…Inhibitors of the renin−angiotensin system used to treat several diseases have also been shown to be effective on bone tissue, suggesting that…”
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The compositional and physicochemical homogeneity of male femoral cortex increases after the sixth decade by Yerramshetty, Janardhan S., Lind, Cora, Akkus, Ozan

“…The temporal and spatial fluctuations in the dynamics of secondary osteonal remodeling impart heterogeneity to the compositional quality of bone. Bone mineral…”
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Comparison of morphology, orientation, and migration of tendon derived fibroblasts and bone marrow stromal cells on electrochemically aligned collagen constructs by Gurkan, Umut Atakan, Cheng, Xingguo, Kishore, Vipuil, Uquillas, Jorge Alfredo, Akkus, Ozan

“…There are approximately 33 million injuries involving musculoskeletal tissues (including tendons and ligaments) every year in the United States. In certain…”
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