Search Results - "Akkermans, Jimmy J."

USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7 by Sapmaz, Aysegul, Berlin, Ilana, Bos, Erik, Wijdeven, Ruud H., Janssen, Hans, Konietzny, Rebecca, Akkermans, Jimmy J., Erson-Bensan, Ayse E., Koning, Roman I., Kessler, Benedikt M., Neefjes, Jacques, Ovaa, Huib

“…The endosomal system is a highly dynamic multifunctional organelle, whose complexity is regulated in part by reversible ubiquitylation. Despite the…”
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Uncoupling DNA damage from chromatin damage to detoxify doxorubicin by Qiao, Xiaohang, van der Zanden, Sabina Y., Wander, Dennis P. A., Borràs, Daniel M., Song, Ji-Ying, Li, Xiaoyang, van Duikeren, Suzanne, van Gils, Noortje, Rutten, Arjo, van Herwaarden, Tessa, van Tellingen, Olaf, Giacomelli, Elisa, Bellin, Milena, Orlova, Valeria, Tertoolen, Leon G. J., Gerhardt, Sophie, Akkermans, Jimmy J., Bakker, Jeroen M., Zuur, Charlotte L., Pang, Baoxu, Smits, Anke M., Mummery, Christine L., Smith, Linda, Arens, Ramon, Li, Junmin, Overkleeft, Hermen S., Neefjes, Jacques

“…The anthracycline doxorubicin (Doxo) and its analogs daunorubicin (Daun), epirubicin (Epi), and idarubicin (Ida) have been cornerstones of anticancer therapy…”
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Mobile late endosomes modulate peripheral endoplasmic reticulum network architecture by Spits, Menno, Heesterbeek, Iris T, Voortman, Lennard M, Akkermans, Jimmy J, Wijdeven, Ruud H, Cabukusta, Birol, Neefjes, Jacques

“…The endoplasmic reticulum (ER) is the largest organelle contacting virtually every other organelle for information exchange and control of processes such as…”
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USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism by Gan, Jin, Pinto-Fernández, Adán, Flierman, Dennis, Akkermans, Jimmy J L L, O'Brien, Darragh P, Greenwood, Helene, Scott, Hannah Claire, Fritz, Günter, Knobeloch, Klaus-Peter, Neefjes, Jacques, van Dam, Hans, Ovaa, Huib, Ploegh, Hidde L, Kessler, Benedikt M, Geurink, Paul P, Sapmaz, Aysegul

“…Interferon-induced ubiquitin (Ub)-like modifier ISG15 covalently modifies host and viral proteins to restrict viral infections. Its function is counteracted by…”
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Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs by Cabukusta, Birol, Berlin, Ilana, van Elsland, Daphne M., Forkink, Iris, Spits, Menno, de Jong, Anja W.M., Akkermans, Jimmy J.L.L., Wijdeven, Ruud H.M., Janssen, George M.C., van Veelen, Peter A., Neefjes, Jacques

“…Membrane contact sites (MCS) are intracellular regions where two organelles come closer to exchange information and material. The majority of the endoplasmic…”
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Multi-omics analyses of cancer-linked clinical salmonellae reveal bacterial-induced host metabolic shift and mTOR-dependent cell transformation by Stévenin, Virginie, Coipan, Claudia E., Duijster, Janneke W., van Elsland, Daphne M., Voogd, Linda, Bigey, Lise, van Hoek, Angela H.A.M., Wijnands, Lucas M., Janssen, Lennert, Akkermans, Jimmy J.L.L., Neefjes-Borst, Andra, Franz, Eelco, Mughini-Gras, Lapo, Neefjes, Jacques

“…Salmonellae are associated epidemiologically and experimentally with colon cancer. To understand how Salmonella induces cell transformation, we performed…”
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Chemical and genetic control of IFNγ‐induced MHCII expression by Wijdeven, Ruud H, van Luijn, Marvin M, Wierenga‐Wolf, Annet F, Akkermans, Jimmy J, van den Elsen, Peter J, Hintzen, Rogier Q, Neefjes, Jacques

“…The cytokine interferon‐γ (IFNγ) can induce expression of MHC class II (MHCII) on many different cell types, leading to antigen presentation to CD4 + T cells…”
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Cellular Validation of a Chemically Improved Inhibitor Identifies Monoubiquitination on OTUB2 by Gan, Jin, de Vries, Jelle, Akkermans, Jimmy J. L. L., Mohammed, Yassene, Tjokrodirijo, Rayman T. N., de Ru, Arnoud H., Kim, Robbert Q., Vargas, David A., Pol, Vito, Fasan, Rudi, van Veelen, Peter A., Neefjes, Jacques, van Dam, Hans, Ovaa, Huib, Sapmaz, Aysegul, Geurink, Paul P.

“…Ubiquitin thioesterase OTUB2, a cysteine protease from the ovarian tumor (OTU) deubiquitinase superfamily, is often overexpressed during tumor progression and…”
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Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs by Cabukusta, Birol, Berlin, Ilana, van Elsland, Daphne M., Forkink, Iris, Spits, Menno, de Jong, Anja W.M., Akkermans, Jimmy J.L.L., Wijdeven, Ruud H.M., Janssen, George M.C., van Veelen, Peter A., Neefjes, Jacques

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The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent by Middelburg, Jim, Ghaffari, Soroush, Schoufour, Tom A.W., Sluijter, Marjolein, Schaap, Gaby, Göynük, Büsra, Sala, Benedetta M., Al-Tamimi, Lejla, Scheeren, Ferenc, Franken, Kees L.M.C., Akkermans, Jimmy J.L.L., Cabukusta, Birol, Joosten, Simone A., Derksen, Ian, Neefjes, Jacques, van der Burg, Sjoerd H., Achour, Adnane, Wijdeven, Ruud H.M., Weidanz, Jon, van Hall, Thorbald

“…The immune checkpoint NKG2A/CD94 is a promising target for cancer immunotherapy, and its ligand major histocompatibility complex E (MHC-E) is frequently…”
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The ORP9-ORP11 dimer promotes sphingomyelin synthesis by Cabukusta, Birol, Borst Pauwels, Shalom, Akkermans, Jimmy J L L, Blomberg, Niek, Mulder, Aat A, Koning, Roman I, Giera, Martin, Neefjes, Jacques

“…Numerous lipids are heterogeneously distributed among organelles. Most lipid trafficking between organelles is achieved by a group of lipid transfer proteins…”
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RNF26 binds perinuclear vimentin filaments to integrate ER and endolysosomal responses to proteotoxic stress by Cremer, Tom, Voortman, Lenard M, Bos, Erik, Jongsma, Marlieke LM, ter Haar, Laurens R, Akkermans, Jimmy JLL, Talavera Ormeño, Cami MP, Wijdeven, Ruud HM, de Vries, Jelle, Kim, Robbert Q, Janssen, George MC, van Veelen, Peter A, Koning, Roman I, Neefjes, Jacques, Berlin, Ilana

“…Proteotoxic stress causes profound endoplasmic reticulum (ER) membrane remodeling into a perinuclear quality control compartment (ERQC) for the degradation of…”
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