Search Results - "Akker, Emile"

Circular RNA expression in human hematopoietic cells is widespread and cell-type specific by Nicolet, Benoit P, Engels, Sander, Aglialoro, Francesca, van den Akker, Emile, von Lindern, Marieke, Wolkers, Monika C

“…Abstract Hematopoietic stem cells differentiate into a broad range of specialized blood cells. This process is tightly regulated and depends on transcription…”
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Genetic programming of macrophages generates an in vitro model for the human erythroid island niche by Lopez-Yrigoyen, Martha, Yang, Cheng-Tao, Fidanza, Antonella, Cassetta, Luca, Taylor, A. Helen, McCahill, Angela, Sellink, Erica, von Lindern, Marieke, van den Akker, Emile, Mountford, Joanne C., Pollard, Jeffrey W., Forrester, Lesley M.

“…Red blood cells mature within the erythroblastic island (EI) niche that consists of specialized macrophages surrounded by differentiating erythroblasts. Here…”
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Transient receptor potential channel vanilloid type 2 in red cells of cannabis consumer by Flormann, Daniel, Qiao, Min, Murciano, Nicoletta, Iacono, Giulia, Darras, Alexis, Hof, Sebastian, Recktenwald, Steffen M., Rotordam, Maria Giustina, Becker, Nadine, Geisel, Jürgen, Wagner, Christian, von Lindern, Marieke, Akker, Emile, Kaestner, Lars

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CD14+ monocytes repress gamma globin expression at early stages of erythropoiesis by Heshusius, Steven, Heideveld, Esther, von Lindern, Marieke, van den Akker, Emile

“…In β-hemoglobinopathies, reactivation of gamma- at the expense of beta-globin is a prominent therapeutic option. Expression of the globin genes is not strictly…”
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A management model in blood, tissue and cell establishments to ensure rapid and sustainable patient access to advanced therapy medicinal products in Europe by Delgadillo, Joaquín, Kerkelä, Erja, Waters, Allison, Akker, Emile van den, Lechanteur, Chantal, Baudoux, Etienne, Gardiner, Nicola, De Vos, John, Vives, Joaquim

“…Blood, tissue and cell establishments (BTCs) stand out in the management of donor selection, procurement and processing of all types of substances of human…”
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Novel variants in Krueppel like factor 1 that cause persistence of fetal hemoglobin in In(Lu) individuals by Eernstman, Jesse, Veldhuisen, Barbera, Ligthart, Peter, von Lindern, Marieke, van der Schoot, C. Ellen, van den Akker, Emile

“…Beta-hemoglobinopathies become prominent after birth due to a switch from γ-globin to the mutated β-globin. Haploinsufficiency for the erythroid specific…”
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SMIM1 missense mutations exert their effect on wild type Vel expression late in erythroid differentiation by Rijst, Marea V. E., Abay, Asena, Aglialoro, Francesca, Schoot, C. Ellen, Akker, Emile

“…Background Vel expression on erythrocytes is variable due to polymorphisms, complicating Vel typing. Weak Vel expression can be caused by mutations within…”
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Epigenomic analysis of KLF1 haploinsufficiency in primary human erythroblasts by Heshusius, Steven, Grech, Laura, Gillemans, Nynke, Brouwer, Rutger W. W., den Dekker, Xander T., van IJcken, Wilfred F. J., Nota, Benjamin, Felice, Alex E., van Dijk, Thamar B., von Lindern, Marieke, Borg, Joseph, van den Akker, Emile, Philipsen, Sjaak

“…Haploinsufficiency for the erythroid-specific transcription factor KLF1 is associated with hereditary persistence of fetal hemoglobin (HPFH). Increased HbF…”
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Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity by Mattebo, Alexander, Sen, Taha, Jassinskaja, Maria, Pimková, Kristýna, Prieto González-Albo, Isabel, Alattar, Abdul Ghani, Ramakrishnan, Ramprasad, Lang, Stefan, Järås, Marcus, Hansson, Jenny, Soneji, Shamit, Singbrant, Sofie, van den Akker, Emile, Flygare, Johan

“…The YPEL family genes are highly conserved across a diverse range of eukaryotic organisms and thus potentially involved in essential cellular processes. Ypel4…”
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Identification of a novel DI02(2558T) allele associated with weakened expression of DI2 antigen by Wen, Jizhi, Akker, Emile, Luo, Guangping, Jia, Shuangshuang, Wei, Ling, Wang, Zhen, Schoot, C. Ellen, Ji, Yanli

“…Background The distribution of DI1/DI2 antigens of the Diego blood group system is polymorphic in Mongoloid populations and the corresponding alloantibodies…”
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A variant RhAG protein encoded by the RHAG572A allele causes serological weak D expression while maintaining normal RhCE phenotypes by Wen, Jizhi, Verhagen, Onno J.H.M., Jia, Shuangshuang, Liang, Qianni, Wang, Zhen, Wei, Ling, Luo, Hong, Luo, Guangping, Vidarsson, Gestur, Akker, Emile, Ji, Yanli, Schoot, C. Ellen

“…BACKGROUND The molecular events resulting in a weak D phenotype include missense mutations, in‐frame insertion, or deletion mutations of the RHD gene and…”
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Identification of a novel single‐nucleotide mutation in SMIM1 gene that results in low Vel antigen expression by Rijst, Marea V.E., Voorn, Lesley, Veldhuisen, Barbera, Jongerius, John M., Akker, Emile, Schoot, C. Ellen

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S277: IPSC DISEASE MODELS TO STUDY AND TREAT DIAMOND‐BLACKFAN ANEMIA SYNDROME (DBAS) by Clark, Chantal, Bartels, Marije, Varga, Ester, Lindern, Marieke, Akker, Emile

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The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLs by Mandoli, Amit, Singh, Abhishek A., Prange, Koen H.M., Tijchon, Esther, Oerlemans, Marjolein, Dirks, Rene, Ter Huurne, Menno, Wierenga, Albertus T.J., Janssen-Megens, Eva M., Berentsen, Kim, Sharifi, Nilofar, Kim, Bowon, Matarese, Filomena, Nguyen, Luan N., Hubner, Nina C., Rao, Nagesha A., van den Akker, Emile, Altucci, Lucia, Vellenga, Edo, Stunnenberg, Hendrik G., Martens, Joost H.A.

“…The t(8;21) acute myeloid leukemia (AML)-associated oncoprotein AML1-ETO disrupts normal hematopoietic differentiation. Here, we have investigated its effects…”
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E-cadherin/β-catenin expression is conserved in human and rat erythropoiesis and marks stress erythropoiesis by Krimpenfort, Rosa A, van der Meulen, Santhe A, Verhagen, Han, Driessen, Michel, Filonova, Galina, Hoogenboezem, Mark, van den Akker, Emile, von Lindern, Marieke, Nethe, Micha

“…E-cadherin is a crucial regulator of epithelial cell-to-cell adhesion and an established tumor suppressor. Aside epithelia, E-cadherin expression marks the…”
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A cellular reporter system to evaluate endogenous fetal hemoglobin induction and screen for therapeutic compounds by Verheul, Thijs C. J., Gillemans, Nynke, Putzker, Kerstin, Majied, Rezin, Li, Tingyue, Vasiliou, Memnia, Eussen, Bert, Klein, Annelies, IJcken, Wilfred F. J., Akker, Emile, Lindern, Marieke, Lewis, Joe, Uhrig, Ulrike, Nakamura, Yukio, Dijk, Thamar, Philipsen, Sjaak

“…Reactivation of fetal hemoglobin expression alleviates the symptoms associated with β‐globinopathies, severe hereditary diseases with significant global health…”
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Thrombocytopenia after meta-iodobenzylguanidine (MIBG) therapy in neuroblastoma patients may be caused by selective MIBG uptake via the serotonin transporter located on megakaryocytes by Blom, Thomas, Meinsma, Rutger, di Summa, Franca, van den Akker, Emile, van Kuilenburg, André B. P., Hansen, Marten, Tytgat, Godelieve A. M.

“…Background The therapeutic use of [ 131 I]meta-iodobenzylguanidine ([ 131 I]MIBG) is often accompanied by hematological toxicity, primarily consisting of…”
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Human‐induced pluripotent stem cell‐derived blood products: state of the art and future directions by Hansen, Marten, von Lindern, Marieke, van den Akker, Emile, Varga, Eszter

“…In vitro cultured blood cells for transfusion purposes provide a safe alternative to donor blood, particularly for patients who require recurrent transfusions,…”
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Mononuclear cells from a rare blood donor, after freezing under good manufacturing practice conditions, generate red blood cells that recapitulate the rare blood phenotype by Masiello, Francesca, Tirelli, Valentina, Sanchez, Massimo, van den Akker, Emile, Gabriella, Girelli, Marconi, Maurizio, Villa, Maria Antonietta, Rebulla, Paolo, Hashmi, Ghazala, Whitsett, Carolyn, Migliaccio, Anna Rita

“…Background Cultured red blood cells (cRBCs) from cord blood (CB) have been proposed as transfusion products. Whether buffy coats discarded from blood donations…”
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The EHA Research Roadmap: Transfusion Medicine by Stanworth, Simon J., Brand, Anneke, Kaveri, Srini V., Vrielink, Hans, Greinacher, Andreas, Domanović, Dragoslav, Lindern, Marieke, Allard, Shubha, Bayry, Jagadeesh, Bohonek, Milos, Buser, Andreas, Claas, Frans H. J., Knutson, Folke, Lozano, Miguel, Olsson, Martin L., Pirenne, France, Rebulla, Paolo, So‐Osman, Cynthia, Tissot, Jean‐Daniel, Toye, Ashley M., Ushiro‐Lumb, Ines, Akker, Emile, Zeerleder, Sacha

“…Transfusion medicine is a broad discipline, encompassing not just use of blood components, but many areas of donor recruitment and safeguarding, apheresis, and…”
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