Search Results - "Akita, Hirofumi"

Serum exosomal miR‐638 is a prognostic marker of HCC via downregulation of VE‐cadherin and ZO‐1 of endothelial cells by Yokota, Yuki, Noda, Takehiro, Okumura, Yuichiro, Kobayashi, Shogo, Iwagami, Yoshifumi, Yamada, Daisaku, Tomimaru, Yoshito, Akita, Hirofumi, Gotoh, Kunihito, Takeda, Yutaka, Tanemura, Masahiro, Murakami, Takashi, Umeshita, Koji, Doki, Yuichiro, Eguchi, Hidetoshi

“…Hepatocellular carcinoma (HCC) is the second leading cause of cancer‐related death. High recurrence rates after curative resection and the lack of specific…”
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Impact of CD36 on Chemoresistance in Pancreatic Ductal Adenocarcinoma by Kubo, Masahiko, Gotoh, Kunihito, Eguchi, Hidetoshi, Kobayashi, Shogo, Iwagami, Yoshifumi, Tomimaru, Yoshito, Akita, Hirofumi, Asaoka, Tadafumi, Noda, Takehiro, Takeda, Yutaka, Tanemura, Masahiro, Mori, Masaki, Doki, Yuichiro

“…Background CD36, a multi-ligand scavenger receptor, has been associated with several cancers. Many studies have revealed that CD36 contributed to cancer…”
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Endogenous CXCL9 affects prognosis by regulating tumor‐infiltrating natural killer cells in intrahepatic cholangiocarcinoma by Fukuda, Yasunari, Asaoka, Tadafumi, Eguchi, Hidetoshi, Yokota, Yuki, Kubo, Masahiko, Kinoshita, Mitsuru, Urakawa, Shinya, Iwagami, Yoshifumi, Tomimaru, Yoshito, Akita, Hirofumi, Noda, Takehiro, Gotoh, Kunihito, Kobayashi, Shogo, Hirata, Michinari, Wada, Hisashi, Mori, Masaki, Doki, Yuichiro

“…CXCL9, an IFN‐γ inducible chemokine, has been reported to play versatile roles in tumor‐host interrelationships. However, little is known about its role in…”
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CD13 is a therapeutic target in human liver cancer stem cells by Haraguchi, Naotsugu, Ishii, Hideshi, Mimori, Koshi, Tanaka, Fumiaki, Ohkuma, Masahisa, Kim, Ho Min, Akita, Hirofumi, Takiuchi, Daisuke, Hatano, Hisanori, Nagano, Hiroaki, Barnard, Graham F, Doki, Yuichiro, Mori, Masaki

“…Cancer stem cells (CSCs) are generally dormant or slowly cycling tumor cells that have the ability to reconstitute tumors. They are thought to be involved in…”
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Inhibition of glycolytic activator PFKFB3 suppresses tumor growth and induces tumor vessel normalization in hepatocellular carcinoma by Matsumoto, Kenichi, Noda, Takehiro, Kobayashi, Shogo, Sakano, Yoshihiro, Yokota, Yuki, Iwagami, Yoshifumi, Yamada, Daisaku, Tomimaru, Yoshito, Akita, Hirofumi, Gotoh, Kunihito, Takeda, Yutaka, Tanemura, Masahiro, Umeshita, Koji, Doki, Yuichiro, Eguchi, Hidetoshi

“…Glycolysis emerges as a new therapeutic target for malignancies. The inhibition of glycolytic activator, PFKFB3, repairs tumor endothelial cell function, and…”
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Tumor endothelial cell‐induced CD8+ T‐cell exhaustion via GPNMB in hepatocellular carcinoma by Sakano, Yoshihiro, Noda, Takehiro, Kobayashi, Shogo, Sasaki, Kazuki, Iwagami, Yoshifumi, Yamada, Daisaku, Tomimaru, Yoshito, Akita, Hirofumi, Gotoh, Kunihito, Takahashi, Hidenori, Asaoka, Tadafumi, Tanemura, Masahiro, Wada, Hisashi, Doki, Yuichiro, Eguchi, Hidetoshi

“…Tumor endothelial cells (TECs) promote tumor angiogenesis and regulate cytotoxic T cells in the tumor microenvironment. However, the roles of TECs for…”
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Heterogeneity of Treg/Th17 According to Cancer Progression and Modification in Biliary Tract Cancers via Self-Producing Cytokines by Kinoshita, Mitsuru, Kobayashi, Shogo, Gotoh, Kunihito, Kubo, Masahiko, Hayashi, Koji, Iwagami, Yoshifumi, Yamada, Daisaku, Akita, Hirofumi, Noda, Takehiro, Asaoka, Tadafumi, Takeda, Yutaka, Tanemura, Masahiro, Eguchi, Hidetoshi, Urakawa, Shinya, Goto, Kumiko, Maekawa, Kayoko, Wada, Hisashi, Mori, Masaki, Doki, Yuichiro

“…Background/Aim We previously demonstrated that inflammatory cytokine interleukin-6 (IL-6) was produced during cancer progression, worked together with…”
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Modeling Pathogenesis of Primary Liver Cancer in Lineage-Specific Mouse Cell Types by Holczbauer, Ágnes, Factor, Valentina M, Andersen, Jesper B, Marquardt, Jens U, Kleiner, David E, Raggi, Chiara, Kitade, Mitsuteru, Seo, Daekwan, Akita, Hirofumi, Durkin, Marian E, Thorgeirsson, Snorri S

“…Background & Aims Human primary liver cancer is classified into biologically distinct subgroups based on cellular origin. Liver cancer stem cells (CSCs) have…”
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Clinical significance of preoperative CA19-9 and lymph node metastasis in intrahepatic cholangiocarcinoma by Asaoka, Tadafumi, Kobayashi, Shogo, Hanaki, Takehiko, Iwagami, Yoshifumi, Tomimaru, Yoshito, Akita, Hirofumi, Noda, Takehiro, Gotoh, Kunihito, Takeda, Yutaka, Tanemura, Masahiro, Doki, Yuichiro, Eguchi, Hidetoshi

“…Purpose This study aimed to identify prognostic factors for patients with ICC after a curative resection and clarify the appropriate indications for surgical…”
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Dysregulation of PI3K and Hippo signaling pathways synergistically induces chronic pancreatitis via CTGF upregulation by Tamura, Takeshi, Kodama, Takahiro, Sato, Katsuhiko, Murai, Kazuhiro, Yoshioka, Teppei, Shigekawa, Minoru, Yamada, Ryoko, Hikita, Hayato, Sakamori, Ryotaro, Akita, Hirofumi, Eguchi, Hidetoshi, Johnson, Randy L, Yokoi, Hideki, Mukoyama, Masashi, Tatsumi, Tomohide, Takehara, Tetsuo

“…The role of PI3K and Hippo signaling in chronic pancreatitis (CP) pathogenesis is unclear. Therefore, we assessed the involvement of these pathways in CP by…”
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N(6)-methyladenosine methylation-regulated polo-like kinase 1 cell cycle homeostasis as a potential target of radiotherapy in pancreatic adenocarcinoma by Tatekawa, Shotaro, Tamari, Keisuke, Chijimatsu, Ryota, Konno, Masamitsu, Motooka, Daisuke, Mitsufuji, Suguru, Akita, Hirofumi, Kobayashi, Shogo, Murakumo, Yoshiki, Doki, Yuichiro, Eguchi, Hidetoshi, Ishii, Hideshi, Ogawa, Kazuhiko

“…In pancreatic cancer, methyltransferase-like 3 (METTL3), a N(6)-methyladenosine (m6A) methyltransferase, has a favorable effect on tumors and is a risk factor…”
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Inhibition of Clusterin Represses Proliferation by Inducing Cellular Senescence in Pancreatic Cancer by Mitsufuji, Suguru, Iwagami, Yoshifumi, Kobayashi, Shogo, Sasaki, Kazuki, Yamada, Daisaku, Tomimaru, Yoshito, Akita, Hirofumi, Asaoka, Tadafumi, Noda, Takehiro, Gotoh, Kunihito, Takahashi, Hidenori, Tanemura, Masahiro, Doki, Yuichiro, Eguchi, Hidetoshi

“…Background The outcome of pancreatic ductal adenocarcinoma (PDAC) is unsatisfactory, and the identification of novel therapeutic targets is urgently needed…”
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Inhibition of c-MET reverses radiation-induced malignant potential in pancreatic cancer by Mori, Soichiro, Akita, Hirofumi, Kobayashi, Shogo, Iwagami, Yoshifumi, Yamada, Daisaku, Tomimaru, Yoshito, Noda, Takehiro, Gotoh, Kunihito, Takeda, Yutaka, Tanemura, Masahiro, Doki, Yuichiro, Eguchi, Hidetoshi

“…As a treatment option for PDAC, radiation therapy induces good local control. However, radiation also reportedly enhances the malignant potential (e.g.,…”
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Randomized study of the effect of synbiotics during neoadjuvant chemotherapy on adverse events in esophageal cancer patients by Motoori, Masaaki, Yano, Masahiko, Miyata, Hiroshi, Sugimura, Keijiro, Saito, Takuro, Omori, Takeshi, Fujiwara, Yoshiyuki, Miyoshi, Norikatsu, Akita, Hirofumi, Gotoh, Kunihito, Takahashi, Hidenori, Kobayashi, Shogo, Noura, Shingo, Ohue, Masayuki, Asahara, Takashi, Nomoto, Koji, Ishikawa, Osamu, Sakon, Masato

“…Summary Background and aims The clinical value of synbiotics in patients receiving neoadjuvant chemotherapy currently remains unclear. The aim of this study…”
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The malignant potential of pancreatic intraductal papillary mucinous neoplasm is reflected in expression levels of fucosylated glycans in α1‐acid glycoprotein by Kubo, Norio, Yazawa, Shin, Yokobori, Takehiko, Sano, Rie, Eguchi, Hidetoshi, Kobayashi, Shogo, Akita, Hirofumi, Mitsufuji, Suguru, Yamashita, Yo‐ichi, Nakao, Yosuke, Fujii, Tsutomu, Okumura, Tomoyuki, Shibuya, Kazuto, Hoshino, Yui, Yamada, Suguru, Hayashi, Masamichi, Shimokawa, Mototsugu, Shirabe, Ken

“…Background Pancreatic intraductal papillary mucinous neoplasm (IPMN) involves multiple histopathological stages from benign to malignant lesions. Further, a…”
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ACAT-1-Regulated Cholesteryl Ester Accumulation Modulates Gemcitabine Resistance in Biliary Tract Cancer by Ueno, Goro, Iwagami, Yoshifumi, Kobayashi, Shogo, Mitsufuji, Suguru, Yamada, Daisaku, Tomimaru, Yoshito, Akita, Hirofumi, Asaoka, Tadafumi, Noda, Takehiro, Gotoh, Kunihito, Mori, Masaki, Doki, Yuichiro, Eguchi, Hidetoshi

“…Background Biliary tract cancer (BTC) has few choices of chemotherapy, including gemcitabine, therefore exploring the mechanisms of gemcitabine resistance is…”
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OMIP 078: A 31‐parameter panel for comprehensive immunophenotyping of multiple immune cells in human peripheral blood mononuclear cells by Nogimori, Takuto, Sugawara, Yuko, Higashiguchi, Masaya, Murakami, Hirotomo, Akita, Hirofumi, Takahama, Shokichi, Tanaka, Satoshi, Yamamoto, Takuya

“…This 31‐parameter panel was developed for simultaneously measuring multiple immune cell populations including T cells, B cells, natural killer cells, dendritic…”
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Clinical Significance of Acylphosphatase 1 Expression in Combined HCC-iCCA, HCC, and iCCA by Sakano, Yoshihiro, Noda, Takehiro, Kobayashi, Shogo, Kitagawa, Akihiro, Iwagami, Yoshifumi, Yamada, Daisaku, Tomimaru, Yoshito, Akita, Hirofumi, Gotoh, Kunihito, Asaoka, Tadafumi, Tanemura, Masahiro, Umeshita, Koji, Mimori, Koshi, Doki, Yuichiro, Eguchi, Hidetoshi

“…Background Combined hepatocellular and cholangiocarcinoma is a rare primary liver cancer with histological features of both hepatocellular carcinoma and…”
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Identification of fucosylated haptoglobin‐producing cells in pancreatic cancer tissue and its molecular mechanism by Ito, Nami, Yamada, Momoko, Morishita, Koichi, Nojima, Satoshi, Motooka, Kei, Sakata, Natsumi, Asuka, Tatsuya, Otsu, Ryoji, Takamatsu, Shinji, Kamada, Yoshihiro, Mori, Soichiro, Akita, Hirofumi, Eguchi, Hidetoshi, Morii, Eiichi, Miyoshi, Eiji

“…Fucosylated haptoglobin is a well-established glyco-biomarker of pancreatic cancer. We recently established a novel anti-glycan antibody (10-7G mAb) that…”
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ASO Author Reflections: ACAT-1-Regulated Cholesteryl Ester Accumulation Modulates Gemcitabine Resistance in Biliary Tract Cancer by Ueno, Goro, Iwagami, Yoshifumi, Kobayashi, Shogo, Mitsufuji, Suguru, Yamada, Daisaku, Tomimaru, Yoshito, Akita, Hirofumi, Asaoka, Tadafumi, Noda, Takehiro, Gotoh, Kunihito, Mori, Masaki, Doki, Yuichiro, Eguchi, Hidetoshi

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