Chemopreventive and remediation effect of Hydrocotyl bonariensis Comm. Ex Lam (Apiaceae) leave extract in galactose-induced cataract

Hydrocotyl bonariensis Comm. Ex Lam (Apiaceae) is being widely used in Western Nigeria in treating various symptoms of ophthalmic diseases; however scientific data in support of this medicinal use have not been reported. This study, investigated the efficacy of Hydrocotyl bonariensis leave extract i...

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Bibliographic Details
Published in:	Journal of ethnopharmacology Vol. 123; no. 1; pp. 134 - 142
Main Authors:	Ajani, E.O., Salako, A.A., Sharlie, P.D., Akinleye, W.A., Adeoye, A.O., Salau, B.A., Adebawo, O.O.
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 04-05-2009 Amsterdam; New York: Elsevier Elsevier
Subjects:	animal models Animals Antioxidant antioxidant activity Antioxidants - pharmacology Apiaceae Apiaceae - chemistry Biological and medical sciences catalase cataract Cataract - prevention & control Cataract index chemoprevention Dietary galactose disease incidence eye lens galactose Galactose - toxicity General pharmacology glutathione Hydrocotyl bonariensis leaves Lens oxidation Lens protein Lens, Crystalline - drug effects Lens, Crystalline - metabolism Lipid Peroxidation Male mechanism of action Medical sciences medicinal plants medicinal properties peroxidation Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extracts Plant Extracts - pharmacology Plant Leaves - chemistry Rats Rats, Wistar superoxide dismutase Nigeria Dietary galactose Apiaceae Hydrocotyl bonariensis Cataract index Antioxidant Lens oxidation Lens protein Extract Medicinal plant Prevention Dicotyledones Angiospermae Oxidation Cataract Pharmacognosy Metabolism Protein Feeding Eye disease Chemotherapy Lens disease Treatment Diet Plant origin Spermatophyta Umbelliferae Pharmacokinetics Anterior segment disease
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Summary:	Hydrocotyl bonariensis Comm. Ex Lam (Apiaceae) is being widely used in Western Nigeria in treating various symptoms of ophthalmic diseases; however scientific data in support of this medicinal use have not been reported. This study, investigated the efficacy of Hydrocotyl bonariensis leave extract in offering protection against experimental cataract and also examined its remediation effect when administered after cataract onset. Weanling albino rats fed with 30% galactose diet were used in the study. Mechanisms of action of the extract were investigated by measuring the degree of lens peroxidation, lens antioxidant status and lens protein concentration. Severity of cataract was determined by measuring the cataract index. The extract at 500 mg kg −1 reduced cataract index significantly and also reduced cataract progression when administered after cataract onset. Administration of this dosage also significantly reduced the degree of lens peroxidation, increased the level of reduced glutathione (GSH) and the lens catalase and superoxide dismutase activity. The extract also prevents protein insolubilization. Administration of the extract at 1000 mg kg −1 reduced cataract index and lens peroxidation but did not increase the antioxidant status significantly. Administration of the extract after cataract onset reduced cataract index, moderately increased percentage soluble protein above the value prior to the arrest of hypergalactosemia but did not increase the antioxidant status. Our study suggests that Hydrocotyl bonariensis protects against galactose-induced cataract, and that administration of the extract after cataract onset reduced cataract progression but did not reverse cataractogenesis.
Bibliography:	http://dx.doi.org/10.1016/j.jep.2009.02.006
ISSN:	0378-8741 1872-7573
DOI:	10.1016/j.jep.2009.02.006