WOUND-HEALING AND POTENTIAL ANTI-KELOIDAL PROPERTIES OF THE LATEX OF CALOTROPIS PROCERA (AITON) ASCLEPIADACEAE IN RABBITS
Calotropis Procera (CP) has been used in the management of toothache, fresh skin burns, gum bleeding as well as others to make it qualify as a medicinal plant. This study was designed to assess its wound-healing property in rabbits and its potentials for anti keloidal activity.Fresh latex of Calotro...
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| Published in: | African journal of traditional, complementary, and alternative medicines Vol. 10; no. 3 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
African Ethnomedicines Network
07-07-2014
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Calotropis Procera (CP) has been used in the management of toothache,
fresh skin burns, gum bleeding as well as others to make it qualify as
a medicinal plant. This study was designed to assess its wound-healing
property in rabbits and its potentials for anti keloidal activity.Fresh
latex of Calotropis were obtained and evaluated phytochemically.
Fifteen male rabbits were used and four excisional wounds were created
on each rabbit. The rabbits were divided into five groups of three
each. Group 1 was the negative control and received no treatment. The
wounds of group 2 animals were treated with 2mL of Calotropis latex;
group 3 with 2mL honey; and group 4 with a mixture of 1ml honey and 1
mL of the latex. The animals in group 5 were given 2mg triamcinolone
intramuscularly. All the groups had their wounds treated daily for 21
days. The wounds' diameters were measured on the day of wound
creation, thereafter on days 7, 14 and 21 post wound creation. Biopsies
of the wounds were taken on days 3 and 21 and viewed histologically.
Phytochemical study of the latex revealed the presence of glycosides,
tannins and alkaloids. The wounds were found to be significantly
(p<0.05) reduced in groups treated with 50% latex in honey and
triamcinolone, respectively, on day 7 post wound creation while there
was a significant (p<0.05) reduction in wound surface area in all
treated groups on days 14 and 21 post wound creation. Histological
findings in untreated group showed thick bundle of collagen fibres some
of which had broad based configurations, reminiscent of keloid. The
group treated with 2mL of Calotropis latex revealed the presence of
florid granulation tissues on day 3 while there was a marked reduction
in quantity and size of collagen fibres on day 21 post wound creation
which was comparable with what was seen for the triamcinolone-treated
group.The general effect of Calotropis latex on wound-healing was
noted. Likewise it's similarity to that of triamcinolone, an
anti-keloidal agent; this makes it a probable candidate for future
anti-keloidal study using a suitable model. |
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| ISSN: | 0189-6016 |