Search Results - "Akil, Ammira"

Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments by Dagar, Gunjan, Gupta, Ashna, Masoodi, Tariq, Nisar, Sabah, Merhi, Maysolun, Hashem, Sheema, Chauhan, Ravi, Dagar, Manisha, Mirza, Sameer, Bagga, Puneet, Kumar, Rakesh, Akil, Ammira S Al-Shabeeb, Macha, Muzafar A, Haris, Mohammad, Uddin, Shahab, Singh, Mayank, Bhat, Ajaz A

“…Traditional cancer treatments use nonspecific drugs and monoclonal antibodies to target tumor cells. Chimeric antigen receptor (CAR)-T cell therapy, however,…”
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Diagnosis and treatment of type 1 diabetes at the dawn of the personalized medicine era by Akil, Ammira Al-Shabeeb, Yassin, Esraa, Al-Maraghi, Aljazi, Aliyev, Elbay, Al-Malki, Khulod, Fakhro, Khalid A

“…Type 1 diabetes affects millions of people globally and requires careful management to avoid serious long-term complications, including heart and kidney…”
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Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance by Bhat, Gh Rasool, Sethi, Itty, Sadida, Hana Q., Rah, Bilal, Mir, Rashid, Algehainy, Naseh, Albalawi, Ibrahim Altedlawi, Masoodi, Tariq, Subbaraj, Gowtham Kumar, Jamal, Farrukh, Singh, Mayank, Kumar, Rakesh, Macha, Muzafar A., Uddin, Shahab, Akil, Ammira S. Al-Shabeeb, Haris, Mohammad, Bhat, Ajaz A.

“…Cancer is a complex disease displaying a variety of cell states and phenotypes. This diversity, known as cancer cell plasticity, confers cancer cells the…”
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Melanocortin‐4 receptor complexity in energy homeostasis,obesity and drug development strategies by Fatima, Munazza Tamkeen, Ahmed, Ikhlak, Fakhro, Khalid Adnan, Akil, Ammira Sarah Al‐Shabeeb

“…The melanocortin‐4 receptor (MC4R) has been critically investigated for the past two decades, and novel findings regarding MC4R signalling and its potential…”
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Deciphering the complex interplay of obesity, epithelial barrier dysfunction, and tight junction remodeling: Unraveling potential therapeutic avenues by AlMarzooqi, Sara K., Almarzooqi, Fajr, Sadida, Hana Q., Jerobin, Jayakumar, Ahmed, Ikhlak, Abou‐Samra, Abdul‐Badi, Fakhro, Khalid A., Dhawan, Punita, Bhat, Ajaz A., Al‐Shabeeb Akil, Ammira S.

“…Summary Obesity stands as a formidable global health challenge, predisposing individuals to a plethora of chronic illnesses such as cardiovascular disease,…”
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A variant in sperm‐specific glycolytic enzyme enolase 4 (ENO4) causes human male infertility by Nawaz, Shoaib, Hussain, Shabir, Bilal, Muhammad, Syed, Najeeb, Liaqat, Khurram, Ullah, Imran, Akil, Ammira Al‐Shabeeb, Fakhro, Khalid A., Ahmad, Wasim

“…Background Although defects in sperm morphology and physiology lead to male infertility, in many instances, the exact disruption of molecular pathways in a…”
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Molecular Analysis and Conformational Dynamics of Human MC4R Disease-Causing Mutations by Fatima, Munazza Tamkeen, Islam, Zeyaul, Kolatkar, Prasanna R., Al-Shabeeb Akil, Ammira Sarah

“…Obesity is a chronic disease with increasing cases among children and adolescents. Melanocortin 4 receptor (MC4R) is a G protein-coupled transporter involved…”
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Neosetophomone B induces apoptosis in multiple myeloma cells via targeting of AKT/SKP2 signaling pathway by Kuttikrishnan, Shilpa, Ahmad, Fareed, Mateo, Jericha M., Prabhu, Kirti S., El‐Elimat, Tamam, Oberlies, Nicholas H., Pearce, Cedric J., Akil, Ammira S. Alshabeeb, Bhat, Ajaz A., Alali, Feras Q., Uddin, Shahab

“…Multiple myeloma (MM) is a hematologic malignancy associated with malignant plasma cell proliferation in the bone marrow. Despite the available treatments,…”
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395-P: Identification of Key Genes and Transcriptional Factors Associated with Podocyte Functions in Human Diabetic Nephropathy by AKIL, AMMIRA S., PADMAJEYA, SUJITHA SUBASH, FAKHRO, KHALID, HABIB, TANWIR

“…Background: Direct podocyte injury in Diabetic nephropathy (DN) leads to proteinuria, glomerular hypertrophy, and accumulation of extra cellular matrix. By…”
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Therapeutic implications of signaling pathways and tumor microenvironment interactions in esophageal cancer by Khan, Inamu Rashid, Sadida, Hana Q., Hashem, Sheema, Singh, Mayank, Macha, Muzafar A., Al-Shabeeb Akil, Ammira S., Khurshid, Ibraq, Bhat, Ajaz A.

“…Esophageal cancer (EC) is significantly influenced by the tumor microenvironment (TME) and altered signaling pathways. Downregulating these pathways in EC is…”
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Anti-angiogenic effect of nano-formulated water soluble kaempferol and combretastatin in an in vivo chick chorioallantoic membrane model and HUVEC cells by Subbaraj, Gowtham Kumar, Masoodi, Tariq, Yasam, Santhosh Kumar, Chandrashekar, Kirubhanand, Kulanthaivel, Langeswaran, Shaik, Noor Ahmad, Hashem, Sheema, Alshabeeb Akil, Ammira S., Bhat, Ajaz A.

“…The present study evaluated the efficacy of nano-formulated water-soluble kaempferol and combretastatin alone and combined against the native kaempferol and…”
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Epigenetic modifications: Key players in cancer heterogeneity and drug resistance by Sadida, Hana Q, Abdulla, Alanoud, Marzooqi, Sara Al, Hashem, Sheema, Macha, Muzafar A, Akil, Ammira S Al-Shabeeb, Bhat, Ajaz A

“…Cancer heterogeneity and drug resistance remain pivotal obstacles in effective cancer treatment and management. One major contributor to these challenges is…”
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Associations between telomere attrition, genetic variants in telomere maintenance genes, and non-small cell lung cancer risk in the Jammu and Kashmir population of North India by Bhat, Gh. Rasool, Jamwal, Rajeshwer Singh, Sethi, Itty, Bhat, Amrita, Shah, Ruchi, Verma, Sonali, Sharma, Minerva, Sadida, Hana Q, Al-Marzooqi, Sara K, Masoodi, Tariq, Mirza, Sameer, Haris, Mohammad, Macha, Muzafar A, Akil, Ammira S. Alshabeeb, Bhat, Ajaz A, Kumar, Rakesh

“…Background Telomeres are repetitive DNA sequences located at the ends of chromosomes, playing a vital role in maintaining chromosomal integrity and stability…”
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Extracellular vesicles as tools and targets in therapy for diseases by Kumar, Mudasir A., Baba, Sadaf K., Sadida, Hana Q., Marzooqi, Sara Al, Jerobin, Jayakumar, Altemani, Faisal H., Algehainy, Naseh, Alanazi, Mohammad A., Abou-Samra, Abdul-Badi, Kumar, Rakesh, Al-Shabeeb Akil, Ammira S., Macha, Muzafar A., Mir, Rashid, Bhat, Ajaz A.

“…Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the extracellular space. They exhibit diverse sizes, contents, and surface…”
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Natural products as chemo-radiation therapy sensitizers in cancers by Nisar, Sabah, Masoodi, Tariq, Prabhu, Kirti S., Kuttikrishnan, Shilpa, Zarif, Lubna, Khatoon, Summaiya, Ali, Shahid, Uddin, Shahab, Akil, Ammira Al-Shabeeb, Singh, Mayank, Macha, Muzafar A., Bhat, Ajaz A.

“…Cancer is a devastating disease and is the second leading cause of death worldwide. Surgery, chemotherapy (CT), and/or radiation therapy (RT) are the treatment…”
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Integration of CRISPR/Cas9 with artificial intelligence for improved cancer therapeutics by Bhat, Ajaz A, Nisar, Sabah, Mukherjee, Soumi, Saha, Nirmalya, Yarravarapu, Nageswari, Lone, Saife N, Masoodi, Tariq, Chauhan, Ravi, Maacha, Selma, Bagga, Puneet, Dhawan, Punita, Akil, Ammira Al-Shabeeb, El-Rifai, Wael, Uddin, Shahab, Reddy, Ravinder, Singh, Mayank, Macha, Muzafar A, Haris, Mohammad

“…Gene editing has great potential in treating diseases caused by well-characterized molecular alterations. The introduction of clustered regularly interspaced…”
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The link between glycemic control measures and eye microvascular complications in a clinical cohort of type 2 diabetes with microRNA-223-3p signature by Da'as, Sahar I, Ahmed, Ikhlak, Hasan, Waseem H, Abdelrahman, Doua A, Aliyev, Elbay, Nisar, Sabah, Bhat, Ajaz Ahmad, Joglekar, Mugdha V, Hardikar, Anandwardhan A, Fakhro, Khalid A, Akil, Ammira S Al-Shabeeb

“…Type 2 diabetes (T2D) is a critical healthcare challenge and priority in Qatar which is listed amongst the top 10 countries in the world, with its prevalence…”
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Mapping the genetic landscape of treatable inherited metabolic disorders in a large Middle Eastern biobank by Devadoss Gandhi, Geethanjali, Aliyev, Elbay, Syed, Najeeb, Vempalli, Fazulur Rehaman, Saad, Chadi, Mbarek, Hamdi, Al-Saei, Omayma, Al-Maraghi, Aljazi, Abdi, Mona, Krishnamoorthy, Navaneethakrishnan, Badii, Ramin, Ismail, Said I., Al-Muftah, Wadha, Badji, Radja, Mbarek, Hamdi, Darwish, Dima, Fadl, Tasnim, Yasin, Heba, Ennaifar, Maryem, Abdellatif, Rania, Alkuwari, Fatima, Alvi, Muhammad, Al-Sarraj, Yasser, Saad, Chadi, Althani, Asmaa, Fethnou, Eleni, Qafoud, Fatima, Alkhayat, Eiman, Afifi, Nahla, Tomei, Sara, Liu, Wei, Lorenz, Stephan, Syed, Najeeb, Almabrazi, Hakeem, Vempalli, Fazulur Rehaman, Temanni, Ramzi, Saqri, Tariq Abu, Khatib, Mohammedhusen, Hamza, Mehshad, Zaid, Tariq Abu, El Khouly, Ahmed, Pathare, Tushar, Poolat, Shafeeq, Al-Ali, Rashid, Albagha, Omar, Al-Khodor, Souhaila, Alshafai, Mashael, Badii, Ramin, Chouchane, Lotfi, Estivill, Xavier, Fakhro, Khalid A., Mokrab, Younes, Puthen, Jithesh V., Suhre, Karsten, Tatari, Zohreh, Akil, Ammira A., Ben-Omran, Tawfeg, Fakhro, Khalid A.

“…To date, approximately 1400 inherited metabolic disorders (IMDs) have been described, some of which are treatable. It is estimated that 2% to 3% of live births…”
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Ubiquitin specific peptidase 37 and PCNA interaction promotes osteosarcoma pathogenesis by modulating replication fork progression by Chauhan, Ravi, Gupta, Ashna, Malhotra, Lakshay, Bhat, Ajaz A, Pandita, Raj K, Masoodi, Tariq, Dagar, Gunjan, Sadida, Hana Q, Al-Marzooqi, Sara K, Batra, Atul, Bakhshi, Sameer, Sharma, Mehar Chand, Tanwar, Pranay, Khan, Shah Alam, Samath, Ethayathulla Abdul, Uddin, Shahab, Akil, Ammira S Al-Shabeeb, Haris, Mohammad, Macha, Muzafar A, Pandita, Tej K, Singh, Mayank

“…Osteosarcoma is a type of bone cancer that predominantly affects young individuals, including children and adolescents. The disease progresses through…”
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437-P: MicroRNA-223 Expression Is Upregulated in Type 2 Diabetes and Associated with Diabetic Retinopathy in Cohort of Qatar Biobank: Functional Validation in Zebrafish Model by AKIL, AMMIRA S., DA’AS, SAHAR, JERMAN, LAILA A., ABDELRAHMAN, DOUA, HASAN, WASEEM, FAKHRO, KHALID

“…MicroRNAs (miRNAs/miRs) are implicated in the pathogenesis of type 2 diabetes (T2D) and its long-term complications such as retinopathy. miRNAs circulating…”
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