Search Results - "Akif, F"

Electron Transfer in Nitrogenase by Rutledge, Hannah L, Tezcan, F. Akif

“…Nitrogenase is the only enzyme capable of reducing N2 to NH3. This challenging reaction requires the coordinated transfer of multiple electrons from the…”
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Overcoming Universal Restrictions on Metal Selectivity by Protein Design by Choi, Tae Su, Tezcan, F. Akif

“…Selective metal coordination is central to the functions of metalloproteins:1,2 each metalloprotein must pair with its cognate metallocofactor to fulfl its…”
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Self-assembly of coherently dynamic, auxetic, two-dimensional protein crystals by Suzuki, Yuta, Cardone, Giovanni, Restrepo, David, Zavattieri, Pablo D., Baker, Timothy S., Tezcan, F. Akif

“…Mutants of the C 4 -symmetric protein RhuA were designed to self-assemble into two-dimensional crystalline lattices with precise spatial arrangements and…”
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Design and Construction of Functional Supramolecular Metalloprotein Assemblies by Churchfield, Lewis A, Tezcan, F. Akif

“…Conspectus Nature puts to use only a small fraction of metal ions in the periodic table. Yet, when incorporated into protein scaffolds, this limited set of…”
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Tunable and Cooperative Thermomechanical Properties of Protein–Metal–Organic Frameworks by Bailey, Jake B, Tezcan, F. Akif

“…We recently introduced protein–metal–organic frameworks (protein-MOFs) as chemically designed protein crystals, composed of ferritin nodes that predictably…”
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A designed supramolecular protein assembly with in vivo enzymatic activity by Song, Woon Ju, Tezcan, F. Akif

“…The generation of new enzymatic activities has mainly relied on repurposing the interiors of preexisting protein folds because of the challenge in designing…”
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An efficient, step-economical strategy for the design of functional metalloproteins by Rittle, Jonathan, Field, Mackenzie J., Green, Michael T., Tezcan, F. Akif

“…The bottom-up design and construction of functional metalloproteins remains a formidable task in biomolecular design. Although numerous strategies have been…”
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Spatially Patterned, Porous Protein Crystals as Multifunctional Materials by Han, Kenneth, Zhang, Zhiyin, Tezcan, F. Akif

“…While the primary use of protein crystals has historically been in crystallographic structure determination, they have recently emerged as promising materials…”
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Design of a Flexible, Zn-Selective Protein Scaffold that Displays Anti-Irving–Williams Behavior by Choi, Tae Su, Tezcan, F. Akif

“…Selective metal binding is a key requirement not only for the functions of natural metalloproteins but also for the potential applications of artificial…”
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Assembly of a patchy protein into variable 2D lattices via tunable multiscale interactions by Zhang, Shuai, Alberstein, Robert G., De Yoreo, James J., Tezcan, F. Akif

“…Self-assembly of molecular building blocks into higher-order structures is exploited in living systems to create functional complexity and represents a…”
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Synthetic Modularity of Protein–Metal–Organic Frameworks by Bailey, Jake B, Zhang, Ling, Chiong, Jerika A, Ahn, Sunhyung, Tezcan, F. Akif

“…Previously, we adopted the construction principles of metal–organic frameworks (MOFs) to design a 3D crystalline protein lattice in which pseudospherical…”
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Protein Assembly by Design by Zhu, Jie, Avakyan, Nicole, Kakkis, Albert, Hoffnagle, Alexander M, Han, Kenneth, Li, Yiying, Zhang, Zhiyin, Choi, Tae Su, Na, Youjeong, Yu, Chung-Jui, Tezcan, F. Akif

“…Proteins are nature’s primary building blocks for the construction of sophisticated molecular machines and dynamic materials, ranging from protein complexes…”
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Constructing protein polyhedra via orthogonal chemical interactions by Golub, Eyal, Subramanian, Rohit H., Esselborn, Julian, Alberstein, Robert G., Bailey, Jake B., Chiong, Jerika A., Yan, Xiaodong, Booth, Timothy, Baker, Timothy S., Tezcan, F. Akif

“…Many proteins exist naturally as symmetrical homooligomers or homopolymers 1 . The emergent structural and functional properties of such protein assemblies…”
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Hyperexpandable, self-healing macromolecular crystals with integrated polymer networks by Zhang, Ling, Bailey, Jake B., Subramanian, Rohit H., Groisman, Alexander, Tezcan, F. Akif

“…The formation of condensed matter typically involves a trade-off between structural order and flexibility. As the extent and directionality of interactions…”
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A Metal Organic Framework with Spherical Protein Nodes: Rational Chemical Design of 3D Protein Crystals by Sontz, Pamela A, Bailey, Jake B, Ahn, Sunhyung, Tezcan, F. Akif

“…We describe here the construction of a three-dimensional, porous, crystalline framework formed by spherical protein nodes that assemble into a prescribed…”
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Metal-directed, chemically tunable assembly of one-, two- and three-dimensional crystalline protein arrays by Brodin, Jeffrey D., Ambroggio, X. I., Tang, Chunyan, Parent, Kristin N., Baker, Timothy S., Tezcan, F. Akif

“…Proteins represent the most sophisticated building blocks available to an organism and to the laboratory chemist. Yet, in contrast to nearly all other types of…”
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Atomically Accurate Design of Metalloproteins with Predefined Coordination Geometries by Hoffnagle, Alexander M., Tezcan, F. Akif

“…We report a new computational protein design method for the construction of oligomeric protein assemblies around metal centers with predefined coordination…”
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Metal-Templated Design of Chemically Switchable Protein Assemblies with High-Affinity Coordination Sites by Kakkis, Albert, Gagnon, Derek, Esselborn, Julian, Britt, R. David, Tezcan, F. Akif

“…To mimic a hypothetical pathway for protein evolution, we previously tailored a monomeric protein (cyt cb562) for metal-mediated self-assembly, followed by…”
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Re-engineering protein interfaces yields copper-inducible ferritin cage assembly by Huard, Dustin J E, Kane, Kathleen M, Tezcan, F Akif

“…A new protein engineering approach inserts metal-coordination motifs to stabilize natural protein interfaces while other favorable contacts are removed,…”
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Importance of Scaffold Flexibility/Rigidity in the Design and Directed Evolution of Artificial Metallo-β-lactamases by Song, Woon Ju, Yu, Jaeseung, Tezcan, F. Akif

“…We describe the design and evolution of catalytic hydrolase activity on a supramolecular protein scaffold, Zn4:C96RIDC14, which was constructed from cytochrome…”
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