Search Results - "Akie, Thomas E."

Direct Recruitment of Polycomb Repressive Complex 1 to Chromatin by Core Binding Transcription Factors by Yu, Ming, Mazor, Tali, Huang, Hui, Huang, Hsuan-Ting, Kathrein, Katie L., Woo, Andrew J., Chouinard, Candace R., Labadorf, Adam, Akie, Thomas E., Moran, Tyler B., Xie, Huafeng, Zacharek, Sima, Taniuchi, Ichiro, Roeder, Robert G., Kim, Carla F., Zon, Leonard I., Fraenkel, Ernest, Cantor, Alan B.

“…Polycomb repressive complexes (PRCs) play key roles in developmental epigenetic regulation. Yet the mechanisms that target PRCs to specific loci in mammalian…”
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OXPHOS-Mediated Induction of NAD+ Promotes Complete Oxidation of Fatty Acids and Interdicts Non-Alcoholic Fatty Liver Disease by Akie, Thomas E, Liu, Lijun, Nam, Minwoo, Lei, Shi, Cooper, Marcus P

“…OXPHOS is believed to play an important role in non-alcoholic fatty liver disease (NAFLD), however, precise mechanisms whereby OXPHOS influences lipid…”
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Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation by Liu, Lijun, Nam, Minwoo, Fan, Wei, Akie, Thomas E, Hoaglin, David C, Gao, Guangping, Keaney, Jr, John F, Cooper, Marcus P

“…Sirtuin 3 (SIRT3), an important regulator of energy metabolism and lipid oxidation, is induced in fasted liver mitochondria and implicated in metabolic…”
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β3-Adrenergic Receptor Stimulation Induces E-Selectin-mediated Adipose Tissue Inflammation by Roth Flach, Rachel J., Matevossian, Anouch, Akie, Thomas E., Negrin, Kimberly A., Paul, Marina T., Czech, Michael P.

“…Inflammation induced by wound healing or infection activates local vascular endothelial cells to mediate leukocyte rolling, adhesion, and extravasation by…”
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Mitochondrial retrograde signaling connects respiratory capacity to thermogenic gene expression by Nam, Minwoo, Akie, Thomas E., Sanosaka, Masato, Craige, Siobhan M., Kant, Shashi, Keaney Jr, John F., Cooper, Marcus P.

“…Mitochondrial respiration plays a crucial role in determining the metabolic state of brown adipose tissue (BAT), due to its direct roles in thermogenesis, as…”
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Differentiation-Dependent Interactions between RUNX-1 and FLI-1 during Megakaryocyte Development by Huang, Hui, Yu, Ming, Akie, Thomas E., Moran, Tyler B., Woo, Andrew J., Tu, Nathan, Waldon, Zachary, Lin, Yin Yin, Steen, Hanno, Cantor, Alan B.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor BCL11A by Sankaran, Vijay G, Menne, Tobias F, Xu, Jian, Akie, Thomas E, Lettre, Guillaume, Van Handel, Ben, Mikkola, Hanna K.A, Hirschhorn, Joel N, Cantor, Alan B, Orkin, Stuart H

“…Differences in the amount of fetal hemoglobin (HbF) that persists into adulthood affect the severity of sickle cell disease and the β-thalassemia syndromes…”
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Physical Examination Sensitivity for Skull Fracture in Pediatric Patients With Blunt Head Trauma: A Secondary Analysis of the National Emergency X-Radiography Utilization Study II Head Computed Tomography Validation Study by Akie, Thomas E., Gupta, Malkeet, Rodriguez, Robert M., Hendey, Gregory W., Wilson, Jake L., Quinones, Alexandra K., Mower, William R.

“…We evaluated the emergency department (ED) providers’ ability to detect skull fractures in pediatric patients presenting with blunt head trauma. This was a…”
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Blunt Head Injury in the Elderly: Analysis of the NEXUS II Injury Cohort by Mower, William R., Akie, Thomas E., Morizadeh, Naseem, Gupta, Malkeet, Hendey, Gregory W., Wilson, Jake L., Leonid Duvergne, Lorenzo Pierre, Ma, Phillip, Krishna, Pravin, Rodriguez, Robert M.

“…Changes with aging make older patients vulnerable to blunt head trauma and alter the potential for injury and the injury patterns seen among this expanding…”
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Characteristics of Intracranial Injuries in Pediatric Patients Following Blunt Head Trauma by Akie, Thomas E, Gupta, Malkeet, Rodriguez, Robert M, Hendey, Gregory W, Wilson, Jake L, Quinones, Alexandra K, Mower, William R

“…Pediatric head trauma is a frequent reason for presentation to the emergency department. Despite this, there are few reports on specific characteristics and…”
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Determination of Fatty Acid Oxidation and Lipogenesis in Mouse Primary Hepatocytes by Akie, Thomas E, Cooper, Marcus P

“…Lipid metabolism in liver is complex. In addition to importing and exporting lipid via lipoproteins, hepatocytes can oxidize lipid via fatty acid oxidation, or…”
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Infantile Myelofibrosis and Myeloproliferation with CDC42 Dysfunction by Verboon, Jeffrey M., Mahmut, Dilnar, Kim, Ah Ram, Nakamura, Mitsutoshi, Abdulhay, Nour J., Nandakumar, Satish K., Gupta, Namrata, Akie, Thomas E., Geddis, Amy E., Manes, Becky, Kapp, Meghan E., Hofmann, Inga, Gabriel, Stacey B., Klein, Daryl E., Williams, David A., Frangoul, Haydar A., Parkhurst, Susan M., Crane, Genevieve M., Cantor, Alan B., Sankaran, Vijay G.

“…Studies of genetic blood disorders have advanced our understanding of the intrinsic regulation of hematopoiesis. However, such genetic studies have only…”
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Developmental differences in IFN signaling affect GATA1s-induced megakaryocyte hyperproliferation by Woo, Andrew J, Wieland, Karen, Huang, Hui, Akie, Thomas E, Piers, Taylor, Kim, Jonghwan, Cantor, Alan B

“…About 10% of Down syndrome (DS) infants are born with a transient myeloproliferative disorder (DS-TMD) that spontaneously resolves within the first few months…”
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Traumatic injury to the posterior fossa: a secondary analysis and description of case series from the NEXUS head injury dataset by Cooper, Richelle J., Akie, Thomas E., Gujral, Tarika, Rana, Shivam, Bui, Kyle, Factora, Ryan, Quinones, Alexandra, Gupta, Malkeet, Hendey, Gregory W., Rodriguez, Robert M., Mower, William R.

“…Traumatic brain injuries involving the posterior fossa are rare and case reports indicate they often result in severe outcomes. We seek to describe…”
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TIF1γ Controls Erythroid Cell Fate by Regulating Transcription Elongation by Bai, Xiaoying, Kim, Jonghwan, Yang, Zhongan, Jurynec, Michael J., Akie, Thomas E., Lee, Joseph, LeBlanc, Jocelyn, Sessa, Anna, Jiang, Hong, DiBiase, Anthony, Zhou, Yi, Grunwald, David J., Lin, Shuo, Cantor, Alan B., Orkin, Stuart H., Zon, Leonard I.

“…Recent genome-wide studies have demonstrated that pausing of RNA polymerase II (Pol II) occurred on many vertebrate genes. By genetic studies in the zebrafish…”
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Traumatic injury to the posterior fossa: a secondary analysis and description of case series from the NEXUS head injury datasetResearch in context by Richelle J. Cooper, Thomas E. Akie, Tarika Gujral, Shivam Rana, Kyle Bui, Ryan Factora, Alexandra Quinones, Malkeet Gupta, Gregory W. Hendey, Robert M. Rodriguez, William R. Mower

“…Background: Traumatic brain injuries involving the posterior fossa are rare and case reports indicate they often result in severe outcomes. We seek to describe…”
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Determination of Fatty Acid Oxidation and Lipogenesis in Mouse Primary Hepatocytes by Akie, Thomas E., Cooper, Marcus P.

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OXPHOS-Mediated Induction of NAD.sup.+ Promotes Complete Oxidation of Fatty Acids and Interdicts Non-Alcoholic Fatty Liver Disease by Akie, Thomas E, Liu, Lijun, Nam, Minwoo, Lei, Shi, Cooper, Marcus P

“…OXPHOS is believed to play an important role in non-alcoholic fatty liver disease (NAFLD), however, precise mechanisms whereby OXPHOS influences lipid…”
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An SCF-FBXW7 Ubiquitin Ligase Mediated Feedback Loop Facilitates GATA Factor Switching and Reinforces Commitment to Terminal Erythroid Maturation by Ghamari, Alireza, Jaensch, Elizabeth, Giadone, Richard, Akie, Thomas E, Xu, Jian, Bauer, Daniel, Orkin, Stuart H., Cantor, Alan B.

“…The GATA family transcription factors GATA2 and GATA1 play reciprocal roles during terminal erythroid and megakaryocytic maturation. GATA2 is expressed early…”
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Differentiation-Dependent Interactions Between Runx-1 and Fli-1 during Megakaryocyte Development by Huang, Hui, Yu, Ming, Moran, Tyler B, Tu, Nathan, Akie, Thomas E, Cantor, Alan B

“…The transcription factor Runx-1 is required for the ontogeny of all definitive hematopoiesis, and plays a specific role in megakaryopoiesis during later stages…”
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