Search Results - "Akhter, Ariz"
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Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphoma
Published in Haematologica (Roma) (01-03-2022)“…B-cell non-Hodgkin lymphoma (B-NHL) encompasses multiple clinically and phenotypically distinct subtypes of malignancy with unique molecular etiologies. Common…”
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A bioclinical prognostic model using MYC and BCL2 predicts outcome in relapsed/refractory diffuse large B-cell lymphoma
Published in Haematologica (Roma) (01-02-2018)“…The objective of this study was to create a bioclinical model, based on clinical and molecular predictors of event-free and overall survival for…”
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"Losing the Brakes"-Suppressed Inhibitors Triggering Uncontrolled Wnt / ß-Catenin Signaling May Provide a Potential Therapeutic Target in Elderly Acute Myeloid Leukemia
Published in Current issues in molecular biology (09-01-2023)“…Dysregulated Wnt/β-catenin signal transduction is implicated in initiation, propagation, and poor prognosis in AML. Epigenetic inactivation is central to…”
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Curability and transferability of atopy with allogeneic hematopoietic cell transplantation
Published in Bone marrow transplantation (Basingstoke) (01-07-2020)“…Atopy is excessive production of IgE in response to allergens. We evaluated in patients undergoing allogeneic hematopoietic cell transplantation (HCT) the…”
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The KIR-HLA-CD16a Immunogenetic Profile Influences NK Cell-Mediated ADCC and Response to Rituximab Therapy in B-Cell Lymphomas
Published in Blood (02-11-2023)“…Rituximab-based chemoimmunotherapy (R-CHOP) is the standard of care in most B-cell lymphomas, however there is marked interpatient heterogeneity in treatment…”
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Unraveling the molecular landscape: a comparative analysis of PI3K and MAPK signaling pathways in plasmablastic lymphoma and diffuse large B-cell lymphoma with therapeutic implications
Published in Human pathology (01-11-2023)“…Plasmablastic lymphoma (PBL) is a rare and aggressive subtype of non-Hodgkin lymphoma that shares features with diffuse large B-cell lymphoma (DLBCL). While…”
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Acute Myeloid Leukaemia in Elderly: Expression Analysis of DNA Damage Response (DDR) and Anti-Apoptosis Genes Identify Novel Targets for Potential “Synergistic Lethality”
Published in Blood (05-11-2020)“…Background: Genetic instability and heterogeneity are fundamental to AML biology and pivotal to its prognosis. Acute myeloid leukaemia (AML) is most frequent…”
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Plasmablastic Lymphoma: Synergism between Wnt/B-Catenin and the RAS S ignalling Molecules May Identify Potential Targets for Therapy
Published in Blood (05-11-2020)“…Background:Plasmablastic lymphoma (PBL), is a rare aggressive B-cell lymphoma that shares many overlapping characteristics with activated B-cell type diffuse…”
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Plasmablastic Lymphoma: Synergism betweenWnt/B-Cateninand theRAS Signalling Molecules May Identify Potential Targets for Therapy
Published in Blood (05-11-2020)“…Background:Plasmablastic lymphoma (PBL), is a rare aggressive B-cell lymphoma that shares many overlapping characteristics with activated B-cell type diffuse…”
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Identification of Potential Therapeutic Targets for Plasmablastic Lymphoma Through Gene Expression Analysis: Insights into RAS and Wnt Signaling Pathways
Published in Modern pathology (01-08-2023)“…Plasmablastic lymphoma (PBL) is a rare and aggressive B-cell lymphoma with overlapping characteristics with diffuse large B-cell lymphoma (DLBCL) and multiple…”
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Up-regulation of BAALC/MN1/MLLT11/EVI1 gene cluster in relation to MYC / BCL2 protein co-expression and poor overall survival in acute myeloid leukemia (AML)
Published in Journal of clinical oncology (20-05-2016)“…Abstract only…”
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Primary testicular lymphoma demonstrates overexpression of the Wilms tumor 1 gene and different mRNA and miRNA expression profiles compared to nodal diffuse large B‐cell lymphoma
Published in Hematological oncology (01-12-2023)“…Diffuse large B‐cell lymphoma (DLBCL) shows a high degree of clinical and biological heterogeneity. Primary testicular lymphoma (PTL) is an extranodal variant…”
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Differential Expression of Immunity Related Genes and Early Prediction of Severe Graft Versus Host Disease after Allogeneic Hematopoietic Cell Transplantation
Published in Blood (02-12-2016)“…Background: Allogeneic hematopoietic cell transplantation (HCT) is curative for hematological malignancies. However, Graft versus host disease (GVHD) is the…”
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Differential Gene Expression Using RNA Sequencing Between Elderly Acute Myeloid Leukemia (AML) Patients with Long Versus Short-Term Survival
Published in Blood (02-12-2016)“…Introduction Advances in genetic sequencing have shed light on the biological underpinnings of AML, however, the vast majority of previous work has focused on…”
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OR45 Influence of NK cell receptors on rituximab-mediated ADCC against different types of lymphomas
Published in Human immunology (01-09-2019)Get full text
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Expression of “DNA damage response” pathway genes in diffuse large B‐cell lymphoma: The potential for exploiting synthetic lethality
Published in Hematological oncology (01-01-2024)“…Diffuse large B‐cell lymphoma (DLBCL) and follicular lymphoma (FL) are two of the most prevalent non‐Hodgkin's lymphoma subtypes. Despite advances, treatment…”
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CD10-positive mantle cell lymphoma: biologically distinct entity or an aberrant immunophenotype? Insight, through gene expression profile in a unique case series
Published in Journal of clinical pathology (01-10-2015)“…Mantle cell lymphoma (MCL) is an aggressive disease with genetic heterogeneity and discrete clinical subtypes. MCL is rarely CD10 positive. These cases raise…”
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OR11 Low content of activating killer immunoglobulin-like receptors predispose to hematological malignancies
Published in Human immunology (01-09-2017)“…Natural killer (NK) cells are critical in surveillance against viral infections and malignancies. Central to the regulation of NK cells is incredible diversity…”
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P027 FCGRIIIA gene variant influences differential rituximab mediated NK cell response against different B-cell lymphoma targets
Published in Human immunology (01-09-2017)“…Rituximab based therapy is the frontline treatment for aggressive B-cell malignancies (Diffuse large B cell lymphoma, DLBCL, Mantle Cell lymphoma, MCL and…”
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