Search Results - "Akhter, Anwari"

Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice by Oladunni, Fatai S., Park, Jun-Gyu, Pino, Paula A., Gonzalez, Olga, Akhter, Anwari, Allué-Guardia, Anna, Olmo-Fontánez, Angélica, Gautam, Shalini, Garcia-Vilanova, Andreu, Ye, Chengjin, Chiem, Kevin, Headley, Colwyn, Dwivedi, Varun, Parodi, Laura M., Alfson, Kendra J., Staples, Hilary M., Schami, Alyssa, Garcia, Juan I., Whigham, Alison, Platt, Roy Neal, Gazi, Michal, Martinez, Jesse, Chuba, Colin, Earley, Stephanie, Rodriguez, Oscar H., Mdaki, Stephanie Davis, Kavelish, Katrina N., Escalona, Renee, Hallam, Cory R. A., Christie, Corbett, Patterson, Jean L., Anderson, Tim J. C., Carrion, Ricardo, Dick, Edward J., Hall-Ursone, Shannan, Schlesinger, Larry S., Alvarez, Xavier, Kaushal, Deepak, Giavedoni, Luis D., Turner, Joanne, Martinez-Sobrido, Luis, Torrelles, Jordi B.

“…Vaccine and antiviral development against SARS-CoV-2 infection or COVID-19 disease would benefit from validated small animal models. Here, we show that…”
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Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis by Abdulrahman, Basant A., Khweek, Arwa Abu, Akhter, Anwari, Caution, Kyle, Kotrange, Sheetal, Abdelaziz, Dalia H.A., Newland, Christie, Rosales-Reyes, Roberto, Kopp, Benjamin, McCoy, Karen, Montione, Richard, Schlesinger, Larry S., Gavrilin, Mikhail A., Wewers, Mark D., Valvano, Miguel A., Amer, Amal O.

“…Cystic fibrosis (CF) is the most common inherited lethal disease of Caucasians which results in multi organ dysfunction. However, 85% of the deaths are due to…”
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Activation of the pyrin inflammasome by intracellular Burkholderia cenocepacia by Gavrilin, Mikhail A, Abdelaziz, Dalia H A, Mostafa, Mahmoud, Abdulrahman, Basant A, Grandhi, Jaykumar, Akhter, Anwari, Abu Khweek, Arwa, Aubert, Daniel F, Valvano, Miguel A, Wewers, Mark D, Amer, Amal O

“…Burkholderia cenocepacia is an opportunistic pathogen that causes chronic infection and induces progressive respiratory inflammation in cystic fibrosis…”
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Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection by Akhter, Anwari, Gavrilin, Mikhail A, Frantz, Laura, Washington, Songcerae, Ditty, Cameron, Limoli, Dominique, Day, Colby, Sarkar, Anasuya, Newland, Christie, Butchar, Jonathan, Marsh, Clay B, Wewers, Mark D, Tridandapani, Susheela, Kanneganti, Thirumala-Devi, Amer, Amal O

“…Legionella pneumophila (L. pneumophila), the causative agent of a severe form of pneumonia called Legionnaires' disease, replicates in human monocytes and…”
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Proteomic analysis of lung responses to SARS-CoV-2 infection in aged non-human primates: clinical and research relevance by Garcia-Vilanova, Andreu, Allué-Guardia, Anna, Chacon, Nadine M., Akhter, Anwari, Singh, Dhiraj Kumar, Kaushal, Deepak, Restrepo, Blanca I., Schlesinger, Larry S., Turner, Joanne, Weintraub, Susan T., Torrelles, Jordi B.

“…With devastating health and socioeconomic impact worldwide, much work is left to understand the Coronavirus Disease 2019 (COVID-19), with emphasis in the…”
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A bacterial protein promotes the recognition of the Legionella pneumophila vacuole by autophagy by Khweek, Arwa A., Caution, Kyle, Akhter, Anwari, Abdulrahman, Basant A., Tazi, Mia, Hassan, Hoda, Majumdar, Neal, Doran, Andrew, Guirado, Evelyn, Schlesinger, Larry S., Shuman, Howard, Amer, Amal O.

“…Legionella pneumophila (L. pneumophila) is an intracellular bacterium of human alveolar macrophages that causes Legionnaires’ disease. In contrast to humans,…”
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Extracellular Delivery of Functional Mitochondria Rescues the Dysfunction of CD4+ T Cells in Aging by Headley, Colwyn A., Gautam, Shalini, Olmo‐Fontanez, Angelica, Garcia‐Vilanova, Andreu, Dwivedi, Varun, Akhter, Anwari, Schami, Alyssa, Chiem, Kevin, Ault, Russell, Zhang, Hao, Cai, Hong, Whigham, Alison, Delgado, Jennifer, Hicks, Amberlee, Tsao, Philip S., Gelfond, Jonathan, Martinez‐Sobrido, Luis, Wang, Yufeng, Torrelles, Jordi B., Turner, Joanne

“…Mitochondrial dysfunction alters cellular metabolism, increases tissue oxidative stress, and may be principal to the dysregulated signaling and function of…”
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Apoptosis-associated Speck-like Protein (ASC) Controls Legionella pneumophila Infection in Human Monocytes by Abdelaziz, Dalia H., Gavrilin, Mikhail A., Akhter, Anwari, Caution, Kyle, Kotrange, Sheetal, Khweek, Arwa Abu, Abdulrahman, Basant A., Grandhi, Jaykumar, Hassan, Zeinab A., Marsh, Clay, Wewers, Mark D., Amer, Amal O.

“…The ability of Legionella pneumophila to cause pneumonia is determined by its capability to evade the immune system and grow within human monocytes and their…”
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Determinant roles of dendritic cell-expressed Notch Delta-like and Jagged ligands on anti-tumor T cell immunity by Tchekneva, Elena E, Goruganthu, Mounika U L, Uzhachenko, Roman V, Thomas, Portia L, Antonucci, Anneliese, Chekneva, Irina, Koenig, Michael, Piao, Longzhu, Akhter, Anwari, de Aquino, Maria Teresa P, Ranganathan, Parvathi, Long, Nicholas, Magliery, Thomas, Valujskikh, Anna, Evans, Jason V, Arasada, Rajeswara R, Massion, Pierre P, Carbone, David P, Shanker, Anil, Dikov, Mikhail M

“…Notch intercellular communication instructs tissue-specific T-cell development and function. In this study, we explored the roles of dendritic cell…”
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Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1β production in macrophages by Kotrange, Sheetal, Kopp, Benjamin, Akhter, Anwari, Abdelaziz, Dalia, Abu Khweek, Arwa, Caution, Kyle, Abdulrahman, Basant, Wewers, Mark D., McCoy, Karen, Marsh, Clay, Loutet, Slade A., Ortega, Ximena, Valvano, Miguel A., Amer, Amal O.

“…B. cenocepacia O antigen, host TLR4 and caspase‐1 contribute to IL‐1β production by infected macrophage. Burkholderia cenocepacia infections in CF patients…”
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Correction to: Determinant roles of dendritic cell-expressed Notch Delta-like and Jagged ligands on anti-tumor T-cell immunity by Tchekneva, Elena E, Goruganthu, Mounika U L, Uzhachenko, Roman V, Thomas, Portia L, Antonucci, Anneliese, Chekneva, Irina, Koenig, Michael, Piao, Longzhu, Akhter, Anwari, de Aquino, Maria Teresa P, Ranganathan, Parvathi, Long, Nicholas, Magliery, Thomas, Valujskikh, Anna, Evans, Jason V, Arasada, Rajeswara R, Massion, Pierre P, Carbone, David P, Shanker, Anil, Dikov, Mikhail M

“…Following publication of the original article [1], the author reported the wrong version of Figs. 5 and 7 have been published. The correct version of the…”
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Animal Models of COVID-19: Transgenic Mouse Model by Park, Jun-Gyu, Pino, Paula A, Akhter, Anwari, Alvarez, Xavier, Torrelles, Jordi B, Martinez-Sobrido, Luis

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), emerged in December 2019 in Wuhan,…”
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HIV infection associated oxidation of innate immune proteins in the human lung mucosa alters the host response to Mycobacterium tuberculosis infection by Akhter, Anwari, Olmo-Fontánez, Angélica, Moliva, Juan, Azad, Abul, Kelley, Holden, Scordo, Julia, Gavrilin, Mikhail, Wewers, Mark, Torrelles, Jordi

“…Abstract Tuberculosis (TB) is the leading killer of people with HIV infection. Limited studies have considered HIV infection associated changes to the soluble…”
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The Lung Mucosa Environment in the Elderly Increases Host Susceptibility to Mycobacterium tuberculosis Infection by Moliva, Juan I, Duncan, Michael A, Olmo-Fontánez, Angélica, Akhter, Anwari, Arnett, Eusondia, Scordo, Julia M, Ault, Russell, Sasindran, Smitha J, Azad, Abul K, Montoya, Maria J, Reinhold-Larsson, Nicole, Rajaram, Murugesan V S, Merrit, Robert E, Lafuse, William P, Zhang, Liwen, Wang, Shu-Hua, Beamer, Gillian, Wang, Yufeng, Proud, Kevin, Maselli, Diego Jose, Peters, Jay, Weintraub, Susan T, Turner, Joanne, Schlesinger, Larry S, Torrelles, Jordi B

“…As we age, there is an increased risk for the development of tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) infection. Few studies consider that…”
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Abstract 5468: Expression of aquaporin 11 as a potential predictor of cisplatin sensitivity by Evans, Jason V., Akhter, Anwari, Carbone, David P., Dikov, Mikhail M., Tchekneva, Elena E.

“…Abstract Platinum-based combination is a standard of care treatment for lung cancer patients. Accumulating evidence indicates that aquaporins are emerging…”
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Multivalent Forms of the Notch Ligand DLL-1 Enhance Antitumor T-cell Immunity in Lung Cancer and Improve Efficacy of EGFR-Targeted Therapy by Biktasova, Asel K, Dudimah, Duafalia F, Uzhachenko, Roman V, Park, Kyungho, Akhter, Anwari, Arasada, Rajeswara R, Evans, Jason V, Novitskiy, Sergey V, Tchekneva, Elena E, Carbone, David P, Shanker, Anil, Dikov, Mikhail M

“…Activation of Notch signaling in hematopoietic cells by tumors contributes to immune escape. T-cell defects in tumors can be reversed by treating tumor-bearing…”
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Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization by Akhter, Anwari, Caution, Kyle, Abu Khweek, Arwa, Tazi, Mia, Abdulrahman, Basant A., Abdelaziz, Dalia H.A., Voss, Oliver H., Doseff, Andrea I., Hassan, Hoda, Azad, Abul K., Schlesinger, Larry S., Wewers, Mark D., Gavrilin, Mikhail A., Amer, Amal O.

“…Inflammasomes are multiprotein complexes that include members of the NLR (nucleotide-binding domain leucine-rich repeat containing) family and caspase-1. Once…”
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HIV infection impairs the host response to Mycobacterium tuberculosis infection by altering surfactant protein D function in the human lung alveolar mucosa by Akhter, Anwari, Moliva, Juan I., Azad, Abul K., Olmo-Fontánez, Angélica, Garcia-Vilanova, Andreu, Scordo, Julia M., Gavrilin, Mikhail A., Diaz, Phillip T., Endsley, Janice J., Weintraub, Susan T., Schlesinger, Larry S., Wewers, Mark D., Torrelles, Jordi B.

“…Tuberculosis is the leading cause of death for people living with HIV (PLWH). We hypothesized that altered functions of innate immune components in the human…”
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Abstract 1624: NOTCH ligand-based therapeutics for immunomodulation in cancer and organ transplantation by Tchekneva, Elena I., Antonucci, Anneliese E., Chekneva, Irina, Long, Nicholas, Evans, Jason V., Akhter, Anwari, Carbone, David P., Magliery, Thomas, Dikov, Mikhail M.

“…Abstract We demonstrated in human and mouse studies that tumor-induced modulation of Notch ligand expression and Notch signaling in hematopoietic compartment…”
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Depletion of the Ubiquitin-binding Adaptor Molecule SQSTM1/p62 from Macrophages Harboring cftr ΔF508 Mutation Improves the Delivery of Burkholderia cenocepacia to the Autophagic Machinery by Abdulrahman, Basant A., Khweek, Arwa Abu, Akhter, Anwari, Caution, Kyle, Tazi, Mia, Hassan, Hoda, Zhang, Yucheng, Rowland, Patrick D., Malhotra, Sankalp, Aeffner, Famke, Davis, Ian C., Valvano, Miguel A., Amer, Amal O.

“…Cystic fibrosis is the most common inherited lethal disease in Caucasians. It is caused by mutations in the cystic fibrosis transmembrane conductance regulator…”
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