Search Results - "Akhmametyeva, Elena M"

Evolution and origin of merlin, the product of the Neurofibromatosis type 2 (NF2) tumor-suppressor gene by Golovnina, Kseniya, Blinov, Alexander, Akhmametyeva, Elena M, Omelyanchuk, Leonid V, Chang, Long-Sheng

“…Merlin, the product of the Neurofibromatosis type 2 (NF2) tumor suppressor gene, belongs to the ezrin-radixin-moesin (ERM) subgroup of the protein 4.1…”
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Histone Deacetylase Inhibitor AR-42 Differentially Affects Cell-cycle Transit in Meningeal and Meningioma Cells, Potently Inhibiting NF2-Deficient Meningioma Growth by BURNS, Sarah S, AKHMAMETYEVA, Elena M, OBLINGER, Janet L, BUSH, Matthew L, JIE HUANG, SENNER, Volker, CHEN, Ching-Shih, JACOB, Abraham, BRADLEY WELLING, D, CHANG, Long-Sheng

“…Meningiomas constitute about 34% of primary intracranial tumors and are associated with increased mortality in patients with neurofibromatosis type 2 (NF2). To…”
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Components of the eIF4F complex are potential therapeutic targets for malignant peripheral nerve sheath tumors and vestibular schwannomas by Oblinger, Janet L, Burns, Sarah S, Akhmametyeva, Elena M, Huang, Jie, Pan, Li, Ren, Yulin, Shen, Rulong, Miles-Markley, Beth, Moberly, Aaron C, Kinghorn, A Douglas, Welling, D Bradley, Chang, Long-Sheng

“…The eukaryotic initiation factor 4F (eIF4F) complex plays a pivotal role in protein translation initiation; however, its importance in malignant and benign…”
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Multiple Transcription Initiation Sites, Alternative Splicing, and Differential Polyadenylation Contribute to the Complexity of Human Neurofibromatosis 2 Transcripts by Chang, Long-Sheng, Akhmametyeva, Elena M., Wu, Yong, Zhu, Lingyun, Welling, D.Bradley

“…Northern blot analysis has shown that the human neurofibromatosis type 2 (NF2) cDNA hybridizes to multiple RNA species. To examine whether these hybridizing…”
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Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells by Lee, Tina X, Packer, Mark D, Huang, Jie, Akhmametyeva, Elena M, Kulp, Samuel K, Chen, Ching-Shih, Giovannini, Marco, Jacob, Abraham, Welling, D. Bradley, Chang, Long-Sheng

“…Abstract Background Vestibular schwannomas (VS) frequently express high levels of activated AKT. Small-molecule inhibitors of AKT signalling may have…”
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AR42, a novel histone deacetylase inhibitor, as a potential therapy for vestibular schwannomas and meningiomas by Bush, Matthew L., Oblinger, Janet, Brendel, Victoria, Santarelli, Griffin, Huang, Jie, Akhmametyeva, Elena M., Burns, Sarah S., Wheeler, Justin, Davis, Jeremy, Yates, Charles W., Chaudhury, Abhik R., Kulp, Samuel, Chen, Ching-Shih, Chang, Long-Sheng, Welling, D. Bradley, Jacob, Abraham

“…Neurofibromatosis type 2 (NF2) is an autosomal-dominant disease that results in the formation of bilateral vestibular schwannomas (VSs) and multiple…”
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Regulation of the Neurofibromatosis 2 gene promoter expression during embryonic development by Akhmametyeva, Elena M., Mihaylova, Maria M., Luo, Huijun, Kharzai, Sadeq, Welling, D. Bradley, Chang, Long‐Sheng

“…Mutations in the Neurofibromatosis 2 (NF2) gene are associated with predisposition to vestibular schwannomas, spinal schwannomas, meningiomas, and ependymomas…”
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The role of Drosophila Merlin in spermatogenesis by Dorogova, Natalia V, Akhmametyeva, Elena M, Kopyl, Sergei A, Gubanova, Natalia V, Yudina, Olga S, Omelyanchuk, Leonid V, Chang, Long-Sheng

“…Drosophila Merlin, the homolog of the human Neurofibromatosis 2 (NF2) gene, is important for the regulation of cell proliferation and receptor endocytosis…”
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Growth of Benign and Malignant Schwannoma Xenografts in Severe Combined Immunodeficiency Mice by Chang, Long-Sheng, Abraham, Jacob, Lorenz, Mark, Rock, Jonathan, Akhmametyeva, Elena M., Mihai, Georgeta, Schmalbrock, Petra, Chaudhury, Abhik R., Lopez, Raul, Yamate, Jyoji, John, Markus R., Wickert, Hannes, Neff, Brian A., Dodson, Edward, Welling, D Bradley

“…Objectives: Models for the development of new treatment options in vestibular schwannoma (VS) treatment are lacking. The purpose of this study is to establish…”
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Induction of apoptosis by the p53-related p73 and partial inhibition by the baculovirus-encoded p35 in neuronal cells by Lo, Warren D., Akhmametyeva, Elena M., Zhu, Lingyun, Friesen, Paul D., Chang, Long-Sheng

“…To better understand whether the p53-related p73 gene could induce neuronal apoptosis, we tested whether p73 induced cell killing in three neuronal cell lines…”
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Over-expression of p73β results in apoptotic death of post-mitotic hNT neurons by Jiang, Yuying, Lo, Warren, Akhmametyeva, Elena M., Chang, Long-Sheng

“…The p53-related p73 protein is an important mediator of apoptosis, development and tumorigenesis. Previously, we showed that over-expression of the p73β…”
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Retinoblastoma-Cyclin-Dependent Kinase Pathway Deregulation in Vestibular Schwannomas by Lasak, John M., Welling, D. Bradley, Akhmametyeva, Elena M., Salloum, Mariah, Chang, Long-Sheng

“…Objectives The purpose of the study was to identify genes of the retinoblastoma protein (pRb)–cyclin‐dependent kinase (CDK) pathway that are deregulated in…”
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Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells by LEE, Tina X, PACKER, Mark D, JIE HUANG, AKHMAMETYEVA, Elena M, KULP, Samuel K, CHEN, Ching-Shih, GIOVANNINI, Marco, JACOB, Abraham, BRADLEY WELLING, D, CHANG, Long-Sheng

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Over-expression of p73beta results in apoptotic death of post-mitotic hNT neurons by Jiang, Yuying, Lo, Warren, Akhmametyeva, Elena M, Chang, Long-Sheng

“…The p53-related p73 protein is an important mediator of apoptosis, development and tumorigenesis. Previously, we showed that over-expression of the p73beta…”
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Analysis of the human neurofibromatosis type 2 gene promoter and its expression by Welling, D.Bradley, Akhmametyeva, Elena M., Daniels, Robert L., Lasak, John M., Zhu, Lingyun, Miles-Markley, Beth A., Chang, Long-Sheng

“…Objective: It is hypothesized that transcriptional regulation plays an important role for neurofibromatosis type 2 (NF2) expression in Schwann cells and other…”
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