Search Results - "Akhil Maheshwari"

Role of platelets in neonatal necrotizing enterocolitis by Maheshwari, Akhil

“…Necrotizing enterocolitis (NEC) is an inflammatory bowel necrosis of premature infants and is a leading cause of morbidity and mortality in infants born…”
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The role of integrins in inflammation and angiogenesis by Mezu-Ndubuisi, Olachi J., Maheshwari, Akhil

“…Integrins are heterodimeric transmembrane cell adhesion molecules made up of alpha (α) and beta (β) subunits arranged in numerous dimeric pairings. These…”
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Principles of Neonatology by Maheshwari, Akhil

“…Written by leading global experts in the field, Principles of Neonatology provides those on the NICU team with clinically focused, evidence-based guidance in…”
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Immunologic and Hematological Abnormalities in Necrotizing Enterocolitis by Maheshwari, Akhil, MD

“…Necrotizing enterocolitis (NEC) is a leading cause of mortality in preterm infants. This article reviews the immunologic and hematological abnormalities…”
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Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK by Wang, Yu, An, Hongying, Liu, Ting, Qin, Caolitao, Sesaki, Hiromi, Guo, Shaodong, Radovick, Sally, Hussain, Mehboob, Maheshwari, Akhil, Wondisford, Fredric E., O’Rourke, Brian, He, Ling

“…Impaired mitochondrial respiratory activity contributes to the development of insulin resistance in type 2 diabetes. Metformin, a first-line antidiabetic drug,…”
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Role of macrophages in fetal development and perinatal disorders by Mezu-Ndubuisi, Olachi J., Maheshwari, Akhil

“…In the fetus and the neonate, altered macrophage function has been implicated not only in inflammatory disorders but also in developmental abnormalities marked…”
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Intestinal dysbiosis and necrotizing enterocolitis: assessment for causality using Bradford Hill criteria by Fundora, Jennifer B., Guha, Pallabi, Shores, Darla R., Pammi, Mohan, Maheshwari, Akhil

“…In recent years, several studies have shown that premature infants who develop NEC frequently display enteric dysbiosis with increased Gram-negative bacteria…”
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Anemia of prematurity: how low is too low? by Cibulskis, Catherine C., Maheshwari, Akhil, Rao, Rakesh, Mathur, Amit M.

“…Anemia of prematurity (AOP) is a common condition with a well-described chronology, nadir hemoglobin levels, and timeline of recovery. However, the underlying…”
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The importance of the AMPK gamma 1 subunit in metformin suppression of liver glucose production by An, Hongying, Wang, Yu, Qin, Caolitao, Li, Mingsong, Maheshwari, Akhil, He, Ling

“…Metformin has been used to treat patients with type 2 diabetes for over 60 years, however, its mechanism of action is still not completely understood. Our…”
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A murine neonatal model of necrotizing enterocolitis caused by anemia and red blood cell transfusions by MohanKumar, Krishnan, Namachivayam, Kopperuncholan, Song, Tanjing, Jake Cha, Byeong, Slate, Andrea, Hendrickson, Jeanne E., Pan, Hua, Wickline, Samuel A., Oh, Joo-Yeun, Patel, Rakesh P., He, Ling, Torres, Benjamin A., Maheshwari, Akhil

“…Necrotizing enterocolitis (NEC) is an idiopathic, inflammatory bowel necrosis of premature infants. Clinical studies have linked NEC with antecedent red blood…”
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Probiotic Bacteria Induce Maturation of Intestinal Claudin 3 Expression and Barrier Function by Patel, Ravi M, Myers, Loren S, Kurundkar, Ashish R, Maheshwari, Akhil, Nusrat, Asma, Lin, Patricia W

“…An immature intestinal epithelial barrier may predispose infants and children to many intestinal inflammatory diseases, such as infectious enteritis,…”
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To transfuse or not transfuse a premature infant: the new complex question by Aucott, Susan W., Maheshwari, Akhil

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Clinical determinants of postoperative outcomes in surgical necrotizing enterocolitis by Garg, Parvesh M., Hitt, Mary M., Blackshear, Chad, Maheshwari, Akhil

“…Objective Investigate predictors of postoperative morbidity and mortality in surgical NEC. Study design We analyzed the clinical outcomes of infants with…”
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Non-coding RNAs in Necrotizing Enterocolitis- A New Frontier? by Nair, Jayasree, Maheshwari, Akhil

“…With the recognition that only 2% of the human genome encodes for a protein, a large part of the "non-coding" portion is now being evaluated for a regulatory…”
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Epigenetics in Necrotizing Enterocolitis by Nair, Jayasree, Maheshwari, Akhil

“…Epigenetic alterations in our genetic material can lead to heritable changes in the risk, clinical manifestations, course, and outcomes of many diseases…”
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Incomplete resection of necrotic bowel may increase mortality in infants with necrotizing enterocolitis by Garg, Parvesh Mohan, Bernieh, Anas, Hitt, Mary M., Kurundkar, Ashish, Adams, Kristen V., Blackshear, Chad, Maheshwari, Akhil, Saad, Ali G.

“…Background Infants with advanced necrotizing enterocolitis (NEC) often need surgical resection of necrotic bowel. We hypothesized that incomplete resection of…”
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Dichotomous development of the gut microbiome in preterm infants by Ho, Thao T B, Groer, Maureen W, Kane, Bradley, Yee, Alyson L, Torres, Benjamin A, Gilbert, Jack A, Maheshwari, Akhil

“…Preterm infants are at risk of developing intestinal dysbiosis with an increased proportion of Gammaproteobacteria. In this study, we sought the clinical…”
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Pathophysiology and Current Management of Necrotizing Enterocolitis by Kasivajjula, Himabindu, Maheshwari, Akhil

“…Necrotizing enterocolitis (NEC), an inflammatory bowel necrosis of preterm infants, is the most common gastrointestinal emergency and a major cause of…”
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Neonatal hyperglycemia induces CXCL10/CXCR3 signaling and microglial activation and impairs long-term synaptogenesis in the hippocampus and alters behavior in rats by Satrom, Katherine M, Ennis, Kathleen, Sweis, Brian M, Matveeva, Tatyana M, Chen, Jun, Hanson, Leif, Maheshwari, Akhil, Rao, Raghavendra

“…Hyperglycemia is common in extremely low gestational age newborns (ELGAN) and is associated with increased mortality and morbidity, including abnormal…”
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Plasma concentrations of inflammatory cytokines rise rapidly during ECMO-related SIRS due to the release of preformed stores in the intestine by McILwain, R Britt, Timpa, Joseph G, Kurundkar, Ashish R, Holt, David W, Kelly, David R, Hartman, Yolanda E, Neel, Mary Lauren, Karnatak, Rajendra K, Schelonka, Robert L, Anantharamaiah, G M, Killingsworth, Cheryl R, Maheshwari, Akhil

“…Extracorporeal membrane oxygenation (ECMO) is a life-saving support system used in neonates and young children with severe cardiorespiratory failure. Although…”
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