Search Results - "Akhigbe, Roland Eghoghosoa"

Codeine-induced sperm DNA damage is mediated predominantly by oxidative stress rather than apoptosis by Ajayi, Ayodeji Folorunso, Akhigbe, Roland Eghoghosoa

“…Background: Opioids have been implicated to induce infertility. Although codeine remains the most used opioid for recreational purpose, no study has documented…”
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Psychoactive drugs and male fertility: impacts and mechanisms by Hamed, Moses Agbomhere, Ekundina, Victor Olukayode, Akhigbe, Roland Eghoghosoa

“…Although psychoactive drugs have their therapeutic values, they have been implicated in the pathogenesis of male infertility. This study highlights…”
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Restoration of Hepatic and Intestinal Integrity by Phyllanthus amarus Is Dependent on Bax/Caspase 3 Modulation in Intestinal Ischemia-/Reperfusion-Induced Injury by Afolabi, Ayobami Oladele, Akhigbe, Tunmise Maryanne, Odetayo, Adeyemi Fatai, Anyogu, Davinson Chuka, Hamed, Moses Agbomhere, Akhigbe, Roland Eghoghosoa

“…Ethnopharmacological relevance: Oxidative stress is a key player in intestinal ischemia/reperfusion (I/R) injury (IIRI) with a tendency to trigger systemic…”
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L-Arginine reverses maternal and pre-pubertal codeine exposure-induced sexual dysfunction via upregulation of androgen receptor gene and NO/cGMP signaling by Akhigbe, Roland Eghoghosoa, Afolabi, Oladele A, Ajayi, Ayodeji F

“…Background Although codeine has been reported to enhance sexual activity by improving penile reflexes, it has been shown to impair fertility indices. Also,…”
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Toxic impacts of arsenic bioaccumulation on urinary arsenic metabolites and semen quality: A systematic and meta-analysis by Akhigbe, Roland Eghoghosoa, Akhigbe, Tunmise Maryanne, Adegbola, Cecilia Adedeji, Oyedokun, Precious Adeoye, Adesoye, Oluwatosin Bukola, Adeogun, Adetomiwa Ezekiel

“…This study aims to investigate the effect of arsenic exposure on urinary levels of arsenic metabolites, semen parameters, and testosterone concentrations. A…”
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Zinc improves sexual performance and erectile function by preventing penile oxidative injury and upregulating circulating testosterone in lead-exposed rats by Besong, Elizabeth Enohnyket, Akhigbe, Tunmise Maryanne, Ashonibare, Precious Jesutofunmi, Oladipo, Abimbola Ayoola, Obimma, Jacinta Nkechi, Hamed, Moses Agbomhere, Adeyemi, Damilare Hakeem, Akhigbe, Roland Eghoghosoa

“…The present study evaluated the effect of lead exposure with and without zinc therapy on male sexual and erectile function. Twenty male Wistar rats were…”
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L-Arginine abrogates maternal and pre-pubertal codeine exposure-induced impaired spermatogenesis and sperm quality by modulating the levels of mRNA encoding spermatogenic genes by Akhigbe, Roland Eghoghosoa, Afolabi, Oladele A, Ajayi, Ayodeji Folorusho

“…Although, codeine has been demonstrated to lower sperm quality; the effects of maternal and prepubertal codeine exposure on male offspring is yet to be…”
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Gut microbiota-gonadal axis: the impact of gut microbiota on reproductive functions by Ashonibare, Victory J, Akorede, Bolaji A, Ashonibare, Precious J, Akhigbe, Tunmise M, Akhigbe, Roland Eghoghosoa

“…The influence of gut microbiota on physiological processes is rapidly gaining attention globally. Despite being under-studied, there are available data…”
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Irisin, Energy Homeostasis and Male Reproduction by Sengupta, Pallav, Dutta, Sulagna, Karkada, Ivan Rolland, Akhigbe, Roland Eghoghosoa, Chinni, Suresh V.

“…Irisin is a novel skeletal muscle- and adipose tissue-secreted peptide. It is conventionally regarded as an adipomyokine and is a cleaved fragment of…”
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Acetate attenuates lead-induced dysregulation of testicular steroidogenesis and spermatogenesis by targeting oxidative stress, inflammatory cytokines, and apoptosis by Besong, Elizabeth Enohnyket, Akhigbe, Tunmise Maryanne, Oyedokun, Precious Adeoye, Hamed, Moses Agbomhere, Akhigbe, Roland Eghoghosoa

“…Lead exposure has been implicated in the aetiopathogenesis of male infertility via an oxidative stress-sensitive pathway. Conversely, acetate has been shown to…”
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Omega-3 fatty acids abrogates oxido-inflammatory and mitochondrial dysfunction-associated apoptotic responses in testis of tamoxifen-treated rats by Odetayo, Adeyemi Fatai, Akhigbe, Roland Eghoghosoa, Hamed, Moses Agbomhere, Balogun, Morufu Eyitayo, Oluwole, David Tolulope, Olayaki, Luqman Aribidesi

“…Tamoxifen (TAM) is a widely used drug in patients with gynecomastia and breast cancer. TAM exerts its anticancer effects via its antiestrogenic activities…”
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A systematic review and meta-analysis of the impact of triclosan exposure on human semen quality by Adegbola, Cecilia Adedeji, Akhigbe, Tunmise Maryanne, Adeogun, Adetomiwa Ezekiel, Tvrdá, Eva, Pizent, Alica, Akhigbe, Roland Eghoghosoa

“…Triclosan is an antibacterial and antifungal compound that is frequently found in personal care and consumer products, and its its impact on male reproductive…”
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Does pyrethroid exposure lower human semen quality? a systematic review and meta-analysis by Akhigbe, Roland Eghoghosoa, Oyedokun, Precious Adeoye, Akhigbe, Tunmise Maryanne, Adenike, Suliat, Oladipo, Ayoola Abimbola, Hughes, Jennifer Rose

“…Pyrethroids are natural organic compounds extracted from flowers of pyrethrums and commonly used as domestic and commercial insecticides. Although it is…”
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Estrogen replacement therapy reverses spatial memory loss and pyramidal cell neurodegeneration in the prefrontal cortex of lead-exposed ovariectomized Wistar rats by Lasisi-Sholola, Abiodun Shukrat, Hammed, Sodiq Opeyemi, Ajike, Richard Adedamola, Akhigbe, Roland Eghoghosoa, Afolabi, Oladele Ayobami

“…[Display omitted] •Lead exposure in ovariectomized rats impaired spatial memory.•This was associated with a decline in serum dopamine level and pyramidal…”
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Staging of the estrous cycle and induction of estrus in experimental rodents: an update by Ajayi, Ayodeji Folorunsho, Akhigbe, Roland Eghoghosoa

“…Determination of the phases of the estrous cycle and induction of estrus (heat) in experimental animals remains useful, especially in reproductive function…”
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The physiology of male reproduction: Impact of drugs and their abuse on male fertility by Ajayi, Ayodeji Folorunsho, Akhigbe, Roland Eghoghosoa

“…Male factor accounts for about 30–50% of infertility. A common cause of male infertility is drug abuse; either illicit or prolonged use of prescribed drugs…”
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Sodium acetate prevents testicular damage in Wistar rats subjected to testicular ischaemia/reperfusion injury by Besong, Elizabeth Enohnyket, Akhigbe, Roland Eghoghosoa

“…The aim of this study was to investigate the potential antioxidant, anti-inflammatory, and sperm function-preserving properties of sodium acetate (ACE), a…”
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Histopathological evaluation of infertility: Lessons from laboratory rodents by Ricken, Albert Markus, Hamed, Moses Agbomhere, Akhigbe, Roland Eghoghosoa

“…Infertility is a growing challenge globally with emerging risk factors. There are effective laboratory tests to evaluate infertility in humans, nevertheless,…”
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Rohypnol‐induced sexual dysfunction is via suppression of hypothalamic‐pituitary‐testicular axis: An experimental study in rats by Oluwole, David Tolulope, Akhigbe, Roland Eghoghosoa, Ajayi, Ayodeji Folorunsho

“…Sexual activity is an essential part of reproductive functions and needed for the maintenance of fertility. Drugs, particularly substances of abuse, impair…”
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HAART and anti‐Koch’s impair sexual competence, sperm quality and offspring quality when used singly and in combination in male Wistar rats by Akhigbe, Roland Eghoghosoa, Hamed, Moses Agbomhere, Odetayo, Adeyemi Fatai

“…This study investigated the impact of the administration of HAART and anti‐Koch's, singly and in combination, on sexual competence and birth statistics. Adult…”
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