Search Results - "Akhigbe, R E"

Impact of hypoxia on male reproductive functions by Oyedokun, P. A., Akhigbe, R. E., Ajayi, L. O., Ajayi, A. F.

“…Male reproductive functions, which include testicular steroidogenesis, spermatogenesis, and sexual/erectile functions are key in male fertility, but may be…”
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SARS-CoV-2 impairs male fertility by targeting semen quality and testosterone level: A systematic review and meta-analysis by V J, Ashonibare, P J, Ashonibare, T M, Akhigbe, Akhigbe, R E

“…Since the discovery of COVID-19 in December 2019, the novel virus has spread globally causing significant medical and socio-economic burden. Although the…”
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Sodium acetate ameliorates doxorubicin-induced cardiac injury via upregulation of Nrf2/HO-1 signaling and downregulation of NFkB-mediated apoptotic signaling in Wistar rats by Adeyemi, D. H., Obembe, O. O., Hamed, M. A., Akhigbe, R. E.

“…Despite the effectiveness of doxorubicin (DOX) in the management of a wide range of cancers, a major challenge is its cardio-toxic effect. Oxidative stress,…”
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Impact of COVID 19 on erectile function by Adeyemi, D. H., Odetayo, A. F., Hamed, M. A., Akhigbe, R. E.

“…Purpose: COVID-19, a novel infection, presented with several complications, including socioeconomical and reproductive health challenges such as erectile…”
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Penile erection and cardiovascular function: effects and pathophysiology by Akorede, B A, Hassan, S A, Akhigbe, R E

“…Penile erection (PE) is a hemodynamic event that results from a neuroendocrine process, and it is influenced by the cardiovascular status of the patient…”
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Metabolic Derangement by Arsenic: a Review of the Mechanisms by Bibha, K., Akhigbe, T. M., Hamed, M. A., Akhigbe, R. E.

“…Studies have implicated arsenic exposure in various pathological conditions, including metabolic disorders, which have become a global phenomenon, affecting…”
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Acetate Abates Arsenic-Induced Male Reproductive Toxicity by Suppressing HDAC and Uric Acid–Driven Oxido-inflammatory NFkB/iNOS/NO Response in Rats by Besong, E. E., Akhigbe, T. M., Obimma, J. N., Obembe, O. O., Akhigbe, R. E.

“…Arsenic is associated with male reproductive toxicity through histone deacetylation and oxido-inflammatory injury. Notwithstanding, short-chain fatty acids…”
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Zinc protects against lead-induced testicular damage via modulation of steroidogenic and xanthine oxidase/uric acid/caspase 3-mediated apoptotic signaling in male Wistar rats by Besong, E. E., Ashonibare, P. J., Obembe, O. O., Folawiyo, M. A., Adeyemi, D. H., Hamed, M. A., Akhigbe, T. M., Akhigbe, R. E.

“…This study evaluated the effect of lead, with or without zinc co-administration, on steroidogenic and xanthine oxidase (XO)/uric acid (UA)/caspase 3-mediated…”
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Sodium acetate abates lead-induced sexual dysfunction by upregulating testosterone-dependent eNOS/NO/cGMP signaling and activating Nrf2/HO-1 in male Wistar rat by Besong, E. E., Ashonibare, P. J., Akhigbe, T. M., Obimma, J. N., Akhigbe, R. E.

“…Oxidative stress has been linked with lead toxicity, including lead-induced sexual dysfunction. On the contrary, sodium acetate has been proven to exert…”
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Zinc improves sexual and erectile function in HAART-treated rats via the upregulation of erectogenic enzymes and maintenance of redox balance by Akhigbe, R. E., Hamed, M. A., Odetayo, A. F., Akhigbe, T. M., Oyedokun, P. A.

“…HAART has been shown to impair sexual function and penile erection via perturbation of penile redox balance, while zinc has been established to exert…”
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Atorvastatin-mediated downregulation of VCAM-1 and XO/UA/caspase 3 signaling averts oxidative damage and apoptosis induced by ovarian ischaemia/reperfusion injury by Afolabi, O. A., Hamed, M. A., Anyogu, D. C., Adeyemi, D. H., Odetayo, A. F., Akhigbe, R. E.

“…Oxidative damage is critical in the pathogenesis of ovarian ischaemia/reperfusion (I/R) injury, and statins have been reported to exert antioxidant activity…”
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Co-administration of HAART and antikoch triggers cardiometabolic dysfunction through an oxidative stress-mediated pathway by Akhigbe, R E, Hamed, M A

“…Antikoch and highly active anti-retroviral therapy are effective drugs in the management of tuberculosis and Human Immunodeficiency Virus, respectively…”
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Methanolic Moringa oleifera leaf extract protects against epithelial barrier damage and enteric bacterial translocation in intestinal I/R: Possible role of caspase 3 by Afolabi, O A., Akhigbe, T M., Akhigbe, R E., Alabi, B A., Gbolagun, O T., Taiwo, M E., Fakeye, O O., Yusuf, E O.

“…Background: Activation of caspase 3 has been implicated in the pathogenesis of I/R injury in various organs, but there is a paucity of data on its role in…”
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Codeine exerts cardiorenal injury via upregulation of adenine deaminase/xanthine oxidase and caspase 3 signaling by Akhigbe, R.E., Ajayi, L.O., Ajayi, A.F.

“…Codeine treatment has been shown to be associated with glucolipid deregulation, though data reporting this are inconsistent and the mechanisms are not well…”
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Suppression of glutathione system and upregulation of caspase 3-dependent apoptosis mediate rohypnol-induced gastric injury by Akhigbe, R. E., Oluwole, D. T., Adegoke, T. E., Hamed, M. A., Anyogu, D. C., Ajayi, A. F.

“…Objectives: This study investigated the impact of rohypnol on gastric tissue integrity. Methods: Forty male Wistar rats were randomized into control, low dose…”
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Upregulation of Uric Acid Production and Caspase 3 Signalling Mediates Rohypnol-Induced Cardiorenal Damage by Akhigbe, R. E., Oladipo, A. A., Oyedokun, P. A., Hamed, M. A., Okeleji, L. O., Ajayi, A. F.

“…The global prevalence of illicit drug use is on the increase with attendant complications like cardiorenal collapse. One such substance of abuse is rohypnol…”
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Andrographis paniculata improves glucose regulation by enhancing insulin sensitivity and upregulating GLUT 4 expression in Wistar rats by Saka, W. A., Oyekunle, O. S., Akhigbe, T. M., Oladipo, O. O., Ajayi, M. B., Adekola, A. T., Omole, A. I., Akhigbe, R. E.

“…Context Although the hypoglycaemic effect of Andrographis paniculata (Burm.f.) Nees [Acanthaceae] has been documented, reports on its effect in an apparently…”
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HAART exacerbates testicular damage and impaired spermatogenesis in anti-Koch-treated rats via dysregulation of lactate transport and glutathione content by Akhigbe, R.E., Hamed, M.A., Aremu, A.O.

“…•Antikoch led to significant reductions in testicular and penile weight.•This is accompanied by alterations in testicular cytoarchitecture and impaired…”
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Zinc normalizes hepatic lipid handling via modulation of ADA/XO/UA pathway and caspase 3 signaling in highly active antiretroviral therapy-treated Wistar rats by Hamed, M.A., Akhigbe, R.E., Aremu, A.O., Odetayo, A.F

“…Although highly active antiretroviral therapy (HAART) is effective in the management of HIV, it has been reported to induce hepatic injury and non-alcoholic…”
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Sexual dysfunction in dichlorvos-exposed male Wistar rat is ameliorated by curcumin and associated with the upregulation of testosterone by Saka, W A, Oladipo, A A, Kolawole, O R, Olayioye, A, Akhigbe, R E

“…Dichlorvos is an organophosphate pesticide that is commonly used for agricultural and domestic control of pests and insects. Despite its usefulness, it exerts…”
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