Search Results - "Akgün, Eyup"

Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5) by Akgün, Eyup, Javed, Muhammad I, Lunzer, Mary M, Powers, Michael D, Sham, Yuk Y, Watanabe, Yoshikazu, Portoghese, Philip S

“…Chemokine release promotes cross-talk between opioid and chemokine receptors that in part leads to reduced efficacy of morphine in the treatment of chronic…”
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Bivalent Ligands That Target μ Opioid (MOP) and Cannabinoid1 (CB1) Receptors Are Potent Analgesics Devoid of Tolerance by Le Naour, Morgan, Akgün, Eyup, Yekkirala, Ajay, Lunzer, Mary M, Powers, Mike D, Kalyuzhny, Alexander E, Portoghese, Philip S

“…Given that μ opioid (MOP) and canabinoid (CB1) receptors are colocalized in various regions of the central nervous system and have been reported to associate…”
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Heteromer Induction: An Approach to Unique Pharmacology? by Portoghese, Philip S, Akgün, Eyup, Lunzer, Mary M

“…It is proposed that two types of opioid receptor heteromers exist: a) those that are constitutive and b) those that are induced by bivalent ligands. Mu opioid…”
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Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception by Akgün, Eyup, Javed, Muhammad I., Lunzer, Mary M., Smeester, Branden A., Beitz, Al J., Portoghese, Philip S.

“…The low effectiveness of morphine and related mu opioid analgesics for the treatment of chronic inflammatory pain is a result of opioid-induced release of…”
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Induced Association of μ Opioid (MOP) and Type 2 Cholecystokinin (CCK2) Receptors by Novel Bivalent Ligands by Zheng, Yaguo, Akgün, Eyup, Harikumar, Kaleeckal G, Hopson, Jessika, Powers, Michael D, Lunzer, Mary M, Miller, Laurence J, Portoghese, Philip S

“…Both μ-opioid (MOP) and type 2 cholecystokinin (CCK2) receptors are present in areas of the central nervous system that are involved in modulation of pain…”
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Synthesis and in Vitro Characterization of Radioiodinatable Benzodiazepines Selective for Type 1 and Type 2 Cholecystokinin Receptors by Akgün, Eyup, Körner, Meike, Gao, Fan, Harikumar, Kaleeckal G, Waser, Beatrice, Reubi, Jean Claude, Portoghese, Philip S, Miller, Laurence J

“…Radiolabeled antagonists of specific peptide receptors identify a higher number of receptor binding sites than agonists and may thus be preferable for in vivo…”
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Supramolecular assembled Keggin based porous material: Synthesis, crystal structure, electrochemical and spectroscopic properties by Akgün, Eyüp, Köse, Muhammet, Tümer, Mehmet

“…[Display omitted] •A Keggin polyoxometalate (POM)-sulfadiazine porous material has been prepared.•The hybrid compound (A) showed irreversible redox processes…”
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Synthesis, structural characterization, electrochemical, photophysical and DNA binding properties of two Anderson POM-based hybrids by Akgün, Eyüp, Mısır, Büşra Albayrak, Köse, Muhammet, Tümer, Mehmet

“…•Two new hybrid compounds (MA and DA) that are composed of Anderson polyoxometalate, metformin and dicyandiamide were synthesized.•Crystal structures of the…”
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FBNTI, a DOR-Selective Antagonist That Allosterically Activates MOR within a MOR–DOR Heteromer by Akgün, Eyup, Lunzer, Mary M, Tian, Defeng, Ansonoff, Michael, Pintar, John, Bruce, Daniel, Hawkinson, Jon E, Wilcox, George L, Portoghese, Philip S

“…This report describes the unique pharmacological profile of FBNTI, a potent DOR antagonist that acts as a MOR agonist via an allosteric mechanism. Binding of…”
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MMG22 Potently Blocks Hyperalgesia in Cisplatin-treated Mice by Cataldo, Giuseppe, Lunzer, Mary M., Akgün, Eyup, Wong, Henry L., Portoghese, Philip S., Simone, Donald A.

“…•The bivalent ligand MMG22 consists of a MOR agonist and mGluR5 antagonist.•MMG22 reduced mechanical hyperalgesia produced by cisplatin in mice.•MMG22 reduced…”
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Combined Glia Inhibition and Opioid Receptor Agonism Afford Highly Potent Analgesics without Tolerance by Akgün, Eyup, Lunzer, Mary M, Portoghese, Philip S

“…Commonly prescribed opioid analgesics produce tolerance upon chronic use due in part to induction of hyperalgesia. Given that two reported bivalent ligands…”
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A bivalent compound targeting CCR5 and the mu opioid receptor treats inflammatory arthritis pain in mice without inducing pharmacologic tolerance by Dutta, Raini, Lunzer, Mary M, Auger, Jennifer L, Akgün, Eyup, Portoghese, Philip S, Binstadt, Bryce A

“…Pain accompanies rheumatoid arthritis and other chronic inflammatory conditions and is difficult to manage. Although opioids provide potent analgesia, chronic…”
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The bivalent ligand MCC22 potently attenuates hyperalgesia in a mouse model of cisplatin-evoked neuropathic pain without tolerance or reward by Cataldo, Giuseppe, Erb, Samuel J., Lunzer, Mary M., Luong, Nhungoc, Akgün, Eyup, Portoghese, Philip S., Olson, Julie K., Simone, Donald A.

“…Cisplatin and other widely employed platinum-based anticancer agents produce chemotherapy-induced peripheral neuropathy (CIPN) that often results in pain and…”
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The bivalent ligand, MMG22, reduces neuropathic pain after nerve injury without the side effects of traditional opioids by Speltz, Rebecca, Lunzer, Mary M., Shueb, Sarah S., Akgün, Eyup, Reed, Rachelle, Kalyuzhny, Alex, Portoghese, Philip S., Simone, Donald A.

“…Functional interactions between the mu opioid receptor (MOR) and the metabotropic glutamate receptor 5 (mGluR5) in pain and analgesia have been well…”
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Targeting putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer model by Smeester, Branden A., Lunzer, Mary M., Akgün, Eyup, Beitz, Alvin J., Portoghese, Philip S.

“…The therapeutic management of chronic pain associated with many cancers is problematic due to the development of tolerance and other adverse effects during the…”
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Combination of a δ-opioid Receptor Agonist and Loperamide Produces Peripherally-mediated Analgesic Synergy in Mice by Bruce, Daniel J, Peterson, Cristina D, Kitto, Kelley F, Akgün, Eyup, Lazzaroni, Sophia, Portoghese, Phillip S, Fairbanks, Carolyn A, Wilcox, George L

“…WHAT WE ALREADY KNOW ABOUT THIS TOPICThe adverse effects of opioids are largely mediated by central μ-opioid receptorsCentral μ- and δ-opioid receptors…”
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Bivalent ligand that activates mu opioid receptor and antagonizes mGluR5 receptor reduces neuropathic pain in mice by Peterson, Cristina D., Kitto, Kelley F., Akgün, Eyup, Lunzer, Mary M., Riedl, Maureen S., Vulchanova, Lucy, Wilcox, George L., Portoghese, Philip S., Fairbanks, Carolyn A.

“…The mu opioid receptor (MOR) and metabotropic glutamate receptor 5 (mGluR5) are well-established pharmacological targets in the management of chronic pain…”
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Synthesis, characterization, X-ray structure and photoluminescence properties of two Ce(III) complexes derived from pentadentate ligands by Köse, Muhammet, Akgün, Eyup, Ceyhan, Gökhan

“…In this study, two new Ce(III) complexes [Ce(L1)(NO3)3]∙H2O and [Ce(L2)(NO3)3]∙H2O were synthesized and characterized by spectroscopic and analytical methods…”
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Bivalent ligand MCC22 potently attenuates nociception in a murine model of sickle cell disease by Cataldo, Giuseppe, Lunzer, Mary M., Olson, Julie K., Akgün, Eyup, Belcher, John D., Vercellotti, Gregory M., Portoghese, Philip S., Simone, Donald A.

“…Sickle cell disease (SCD) is a chronic inflammatory disorder accompanied by chronic pain. In addition to ongoing pain and hyperalgesia, vaso-occlusive…”
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A novel Schiff base: Synthesis, structural characterisation and comparative sensor studies for metal ion detections by Köse, Muhammet, Purtas, Savas, Güngör, Seyit Ali, Ceyhan, Gökhan, Akgün, Eyup, McKee, Vickie

“…[Display omitted] •A novel Schiff base compound (L) was synthesised and characterised.•Molecular structure of the compound was determined by single crystal…”
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