New phenanthroline nickel(II) organodithio-phosphorus complexes: Syntheses, structural characterizations and in vitro cytotoxic activity studies

New phenanthroline nickel(II) organodithio-phosphorus complexes were synthesized and structurally characterized by single crystal X-ray diffraction analysis. The in vitro cytotoxic activities of the phenanthroline nickel(II) organodithio-phosphorus complexes were studied for the first time. [Display...

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Bibliographic Details
Published in:	Polyhedron Vol. 199; p. 115097
Main Authors:	Sağlam, Ertuğrul Gazi, Akkoç, Senem, Zorlu, Yunus, Bulat, Elif, Akgün, Aziz
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 01-05-2021
Subjects:	Anticancer Antiproliferative activity Cytotoxic activity Phenanthroline dithiophosphinate complexes Phenanthroline dithiophosphonate complexes Single crystal X-ray analysis Phenanthroline dithiophosphonate complexes Single crystal X-ray analysis Antiproliferative activity Anticancer Phenanthroline dithiophosphinate complexes Cytotoxic activity
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Summary:	New phenanthroline nickel(II) organodithio-phosphorus complexes were synthesized and structurally characterized by single crystal X-ray diffraction analysis. The in vitro cytotoxic activities of the phenanthroline nickel(II) organodithio-phosphorus complexes were studied for the first time. [Display omitted] •New phenanthroline nickel(II) organodithio-phosphorus complexes were synthesized and characterized.•X-ray structure analyses were done.•In vitro cytotoxic activity of phenanthroline nickel(II) organodithio-phosphorus complexes were studied for the first time. Seven different dithiophosphonato Ni(II) complexes, [Ni(Xn)2], (Xn = (4-MeO-C6H4)PS2(OR) where R = 3-pentyl-, X1; R = 1-phenyl-1-propyl-, X2; R = 4-tert-butyl benzyl-, X3; R = diphenylmethyl-, X4; R = 4-tert-butyl cyclohexyl-, X5; R = 3-phenyl-1-propyl-, X6; R = 3-methyl-1-butyl-, X7) and three different dithiophosphinato Ni(II) complexes, [Ni(Yn)2], (Yn = (4-MeO-C6H4)PS2(R) where R = 3-methyl-1-butyl-, Y1; R = 2-methyl propyl-, Y2; R = 1-methyl propyl-, Y3) were prepared by the reaction of NiCl2·6H2O and the ammonium salts of the corresponding dithiophosphonic and dithiophosphinic acids, [NH4][Xn] and [NH4][Yn], respectively. Starting with these complexes, that were known previously, new organo-dithiophosphonate salts of tris-phenanthroline Ni(II), [Ni(Phen)3][(Xn)2] and organo-dithiophosphinate salts of the same complex, [Ni(Phen)3][(Yn)2], were synthesized and characterized. Structural studies were based on spectroscopic methods (mass spectrometry (ESI), FT-IR, Raman spectroscopy), magnetic susceptibility measurements and elemental analysis. The crystal structures of [Ni(Phen)3][(X1)2], [Ni(Phen)3][(X3)2], [Ni(Phen)3][(X4)2] and [Ni(Phen)3][(Y2)2] were determined by single crystal X-ray diffraction analysis. All the complexes were screened against human cell lines for assessing their cytotoxicity. Especially, [Ni(Phen)3][(Y3)2] had the highest cytotoxic potency towards the HepG2 cell line, with an IC50 value comparable to oxaliplatin. Moreover, [Ni(Phen)3][(X1)2]-[Ni(Phen)3][(X3)2] were found to have significant cytotoxic activity against the breast cancer cell line with IC50 values of 51.64, 54.19 and 48.58 μM, respectively.
ISSN:	0277-5387
DOI:	10.1016/j.poly.2021.115097