Search Results - "Akers, Walter J."

Noninvasive Photoacoustic and Fluorescence Sentinel Lymph Node Identification using Dye-Loaded Perfluorocarbon Nanoparticles by Akers, Walter J, Kim, Chulhong, Berezin, Mikhail, Guo, Kevin, Fuhrhop, Ralph, Lanza, Gregory M, Fischer, Georg M, Daltrozzo, Ewald, Zumbusch, Andreas, Cai, Xin, Wang, Lihong V, Achilefu, Samuel

“…The contrast mechanisms used for photoacoustic tomography (PAT) and fluorescence imaging differ in subtle, but significant, ways. The design of contrast agents…”
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Optical See-Through Cancer Vision Goggles Enable Direct Patient Visualization and Real-Time Fluorescence-Guided Oncologic Surgery by Mondal, Suman B., Gao, Shengkui, Zhu, Nan, Habimana-Griffin, LeMoyne, Akers, Walter J., Liang, Rongguang, Gruev, Viktor, Margenthaler, Julie, Achilefu, Samuel

“…Background The inability to visualize the patient and surgical site directly, limits the use of current near infrared fluorescence-guided surgery systems for…”
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Optical Imaging of Mammary and Prostate Tumors in Living Animals using a Synthetic Near Infrared Zinc(II)-Dipicolylamine Probe for Anionic Cell Surfaces by Smith, Bryan A, Akers, Walter J, Leevy, W. Matthew, Lampkins, Andrew J, Xiao, Shuzhang, Wolter, William, Suckow, Mark A, Achilefu, Samuel, Smith, Bradley D

“…In vivo optical imaging shows that a fluorescent imaging probe, comprised of a near-infrared fluorophore attached to an affinity group containing two…”
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An integrated single-cell RNA-seq map of human neuroblastoma tumors and preclinical models uncovers divergent mesenchymal-like gene expression programs by Chapple, Richard H, Liu, Xueying, Natarajan, Sivaraman, Alexander, Margaret I M, Kim, Yuna, Patel, Anand G, LaFlamme, Christy W, Pan, Min, Wright, William C, Lee, Hyeong-Min, Zhang, Yinwen, Lu, Meifen, Koo, Selene C, Long, Courtney, Harper, John, Savage, Chandra, Johnson, Melissa D, Confer, Thomas, Akers, Walter J, Dyer, Michael A, Sheppard, Heather, Easton, John, Geeleher, Paul

“…Neuroblastoma is a common pediatric cancer, where preclinical studies suggest that a mesenchymal-like gene expression program contributes to chemotherapy…”
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Multispectral imaging in the extended near-infrared window based on endogenous chromophores by Cao, Qian, Zhegalova, Natalia G, Wang, Steven T, Akers, Walter J, Berezin, Mikhail Y

“…To minimize the problem with scattering in deep tissues while increasing the penetration depth, we explored the feasibility of imaging in the relatively…”
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Ablation of VLA4 in multiple myeloma cells redirects tumor spread and prolongs survival by Hathi, Deep, Chanswangphuwana, Chantiya, Cho, Nicholas, Fontana, Francesca, Maji, Dolonchampa, Ritchey, Julie, O’Neal, Julie, Ghai, Anchal, Duncan, Kathleen, Akers, Walter J., Fiala, Mark, Vij, Ravi, DiPersio, John F., Rettig, Michael, Shokeen, Monica

“…Multiple myeloma (MM) is a cancer of bone marrow (BM) plasma cells, which is increasingly treatable but still incurable. In 90% of MM patients, severe…”
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Dual-radiolabeled nanoparticle SPECT probes for bioimaging by Black, Kvar C L, Akers, Walter J, Sudlow, Gail, Xu, Baogang, Laforest, Richard, Achilefu, Samuel

“…A gold nanoparticle was radiolabeled with (125)I and (111)In and functionalized with an MMP9-cleavable peptide to form a multispectral SPECT imaging contrast…”
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Hands-free, wireless goggles for near-infrared fluorescence and real-time image-guided surgery by Liu, Yang, BS, Bauer, Adam Q., PhD, Akers, Walter J., DVM, PhD, Sudlow, Gail, BS, Liang, Kexian, BS, Shen, Duanwen, PhD, Berezin, Mikhail Y., PhD, Culver, Joseph P., PhD, Achilefu, Samuel, PhD

“…Background Current cancer management faces several challenges, including the occurrence of a residual tumor after resection, the use of radioactive materials…”
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Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes by Kim, Chulhong, Erpelding, Todd N, Maslov, Konstantin, Jankovic, Ladislav, Akers, Walter J, Song, Liang, Achilefu, Samuel, Margenthaler, Julie A, Pashley, Michael D, Wang, Lihong V

“…By modifying a clinical ultrasound array system, we develop a novel handheld photoacoustic probe for image-guided needle biopsy. The integration of optical…”
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Protonation and Trapping of a Small pH-Sensitive Near-Infrared Fluorescent Molecule in the Acidic Tumor Environment Delineate Diverse Tumors in Vivo by Gilson, Rebecca C, Tang, Rui, Som, Avik, Klajer, Chloe, Sarder, Pinaki, Sudlow, Gail P, Akers, Walter J, Achilefu, Samuel

“…Enhanced glycolysis and poor perfusion in most solid malignant tumors create an acidic extracellular environment, which enhances tumor growth, invasion, and…”
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Breaking the depth dependency of phototherapy with Cerenkov radiation and low-radiance-responsive nanophotosensitizers by Kotagiri, Nalinikanth, Sudlow, Gail P., Akers, Walter J., Achilefu, Samuel

“…The combination of light and photosensitizers for phototherapeutic interventions, such as photodynamic therapy, has transformed medicine and biology. However,…”
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Long Fluorescence Lifetime Molecular Probes Based on Near Infrared Pyrrolopyrrole Cyanine Fluorophores for In Vivo Imaging by Berezin, Mikhail Y., Akers, Walter J., Guo, Kevin, Fischer, Georg M., Daltrozzo, Ewald, Zumbusch, Andreas, Achilefu, Samuel

“…Fluorescence lifetime (FLT) properties of organic molecules provide a new reporting strategy for molecular imaging in the near infrared (NIR) spectral region…”
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All-near-infrared multiphoton microscopy interrogates intact tissues at deeper imaging depths than conventional single- and two-photon near-infrared excitation microscopes by Sarder, Pinaki, Yazdanfar, Siavash, Akers, Walter J, Tang, Rui, Sudlow, Gail P, Egbulefu, Christopher, Achilefu, Samuel

“…The era of molecular medicine has ushered in the development of microscopic methods that can report molecular processes in thick tissues with high spatial…”
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An End-To-End Pipeline for Fully Automatic Morphological Quantification of Mouse Brain Structures From MRI Imagery by Alam, Shahinur, Eom, Tae-Yeon, Steinberg, Jeffrey, Ackerman, David, Schmitt, J Eric, Akers, Walter J, Zakharenko, Stanislav S, Khairy, Khaled

“…Segmentation of mouse brain magnetic resonance images (MRI) based on anatomical and/or functional features is an important step towards morphogenetic brain…”
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Evaluation of Inflammatory Response to Acute Ischemia Using Near-Infrared Fluorescent Reactive Oxygen Sensors by Magalotti, Selena, Gustafson, Tiffany P., Cao, Qian, Abendschein, Dana R., Pierce, Richard A., Berezin, Mikhail Y., Akers, Walter J.

“…Purpose Ischemia-related processes associated with the generation of inflammatory molecules such as reactive oxygen species (ROS) are difficult to detect at…”
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Detection of enzyme activity in orthotopic murine breast cancer by fluorescence lifetime imaging using a fluorescence resonance energy transfer-based molecular probe by Solomon, Metasebya, Guo, Kevin, Sudlow, Gail P, Berezin, Mikhail Y, Edwards, W. Barry, Achilefu, Samuel, Akers, Walter J

“…Cancer-related enzyme activity can be detected noninvasively using activatable fluorescent molecular probes. In contrast to "always-on" fluorescent molecular…”
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Multimodal Imaging of Integrin Receptor-Positive Tumors by Bioluminescence, Fluorescence, Gamma Scintigraphy, and Single-Photon Emission Computed Tomography Using a Cyclic RGD Peptide Labeled with a Near-Infrared Fluorescent Dye and a Radionuclide by Edwards, W. Barry, Akers, Walter J., Ye, Yunpeng, Cheney, Philip P., Bloch, Sharon, Xu, Baogang, Laforest, Richard, Achilefu, Samuel

“…Integrins, particularly the αvβ3 heterodimers, play important roles in tumor-induced angiogenesis and invasiveness. To image the expression pattern of the αvβ3…”
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Interleukin-15 Enhances Anti-GD2 Antibody-Mediated Cytotoxicity in an Orthotopic PDX Model of Neuroblastoma by Nguyen, Rosa, Moustaki, Ardiana, Norrie, Jacqueline L, Brown, Shantel, Akers, Walter J, Shirinifard, Abbas, Dyer, Michael A

“…Immunotherapy with IL2, GM-CSF, and an anti-disialoganglioside (GD2) antibody significantly increases event-free survival in children with high-risk…”
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Dynamic noninvasive monitoring of renal function in vivo by fluorescence lifetime imaging by Goiffon, Reece J, Akers, Walter J, Berezin, Mikhail Y, Lee, Hyeran, Achilefu, Samuel

“…Kidneys normally filter the blood of excess salts and metabolic products, such as urea, while retaining plasma proteins. In diseases such as multiple myeloma…”
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Monitoring of Biodistribution and Persistence of Conditionally Replicative Adenovirus in a Murine Model of Ovarian Cancer Using Capsid-Incorporated mCherry and Expression of Human Somatostatin Receptor Subtype 2 Gene by Dmitriev, Igor P., Kashentseva, Elena A., Kim, Kenneth H., Matthews, Qiana L., Krieger, Stephanie S., Parry, Jesse J., Nguyen, Kim N., Akers, Walter J., Achilefu, Samuel, Rogers, Buck E., Alvarez, Ronald D., Curiel, David T.

“…A significant limiting factor to the human clinical application of conditionally replicative adenovirus (CRAd)-based virotherapy is the inability to…”
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