Search Results - "Akers, Austin"

Flavors Enhance Nicotine Vapor Self-administration in Male Mice by Cooper, Skylar Y, Akers, Austin T, Henderson, Brandon J

“…Abstract Introduction Although the use of combustible cigarettes has decreased in many urban regions of America, the use of electronic nicotine delivery…”
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Anticancer Activity of Natural and Synthetic Capsaicin Analogs by Friedman, Jamie R, Nolan, Nicholas A, Brown, Kathleen C, Miles, Sarah L, Akers, Austin T, Colclough, Kate W, Seidler, Jessica M, Rimoldi, John M, Valentovic, Monica A, Dasgupta, Piyali

“…The nutritional compound capsaicin is the major spicy ingredient of chili peppers. Although traditionally associated with analgesic activity, recent studies…”
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Acetylcholine signaling system in progression of lung cancers by Friedman, Jamie R., Richbart, Stephen D., Merritt, Justin C., Brown, Kathleen C., Nolan, Nicholas A., Akers, Austin T., Lau, Jamie K., Robateau, Zachary R., Miles, Sarah L., Dasgupta, Piyali

“…The neurotransmitter acetylcholine (ACh) acts as an autocrine growth factor for human lung cancer. Several lines of evidence show that lung cancer cells…”
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Why flavored vape products may be attractive: Green apple tobacco flavor elicits reward-related behavior, upregulates nAChRs on VTA dopamine neurons, and alters midbrain dopamine and GABA neuron function by Avelar, Alicia J., Akers, Austin T., Baumgard, Zachary J., Cooper, Skylar Y., Casinelli, Gabriella P., Henderson, Brandon J.

“…While nicotine is the primary addictive component in tobacco products, additional flavors have become a concern with the growing popularity of electronic…”
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Novel Putative Positive Modulators of α4β2 nAChRs Potentiate Nicotine Reward-Related Behavior by Cooper, Skylar Y, Akers, Austin T, Journigan, Velvet Blair, Henderson, Brandon J

“…The popular tobacco and e-cigarette chemical flavorant (-)-menthol acts as a nonselective, noncompetitive antagonist of nicotinic acetylcholine receptors…”
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Anti‐invasive and anti‐metastatic activity of capsaicin and natural capsaicin‐like compounds in lung adenocarcinoma by Richbart, Stephen D., Nolan, Nicholas A., Akers, Austin T., Brown, Kathleen C., Denning, Krista L., Egleton, Richard D., Dasgupta, Piyali

“…Lung adenocarcinoma (LAC) accounts for about 65% of all non‐small cell lung cancer (NSCLC) cases. A considerable proportion of LAC patients present (in the…”
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The choline acetyltransferase inhibitor BW813U inhibits angiogenesis and tumor growth in human lung adenocarcinoma by Dasgupta, Piyali, Richbart, Stephen D., Akers, Austin T., Friedman, Jamie R., Miles, Sarah L., Bow, Eric W., Rimoldi, John M., Chen, Yi Charlie

“…Angiogenesis refers to the development of new blood vessels from preexisting blood vessels. The angiogenic pathway is essential for the growth and progression…”
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Spherical Invasion Assay: A novel method to measure the pro‐invasive activity of cancer cells by Sugrue, Amanda M., Nolan, Nicholas A., Richbart, Stephen D., Akers, Austin T., Brown, Kathleen C., Dasgupta, Piyali

“…Tumor invasion refers to the process by which cancer cells penetrate the basement membrane into surrounding stroma, neighboring blood vessels and lymph nodes…”
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Capsaicin synergizes with camptothecin to induce increased apoptosis in human small cell lung cancers via the calpain pathway by Friedman, Jamie R., Perry, Haley E., Brown, Kathleen C., Gao, Ying, Lin, Ju, Stevenson, Cathyrn D., Hurley, John D., Nolan, Nicholas A., Akers, Austin T., Chen, Yi Charlie, Denning, Krista L., Brown, Linda G., Dasgupta, Piyali

“…[Display omitted] Small cell lung cancer (SCLC) is characterized by excellent initial response to chemotherapy and radiation therapy with a majority of the…”
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Green Apple e-Cigarette Flavorant Farnesene Triggers Reward-Related Behavior by Promoting High-Sensitivity nAChRs in the Ventral Tegmental Area by Cooper, Skylar Y, Akers, Austin T, Henderson, Brandon J

“…While combustible cigarette smoking has declined, the use of electronic nicotine delivery systems (ENDS) has increased. ENDS are popular among adolescents, and…”
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Upregulation of nAChRs and Changes in Excitability on VTA Dopamine and GABA Neurons Correlates to Changes in Nicotine-Reward-Related Behavior by Akers, Austin T, Cooper, Skylar Y, Baumgard, Zachary J, Casinelli, Gabriella P, Avelar, Alicia J, Henderson, Brandon J

“…Previous reports indicate that nicotine reward is mediated through α4β2*, α6β2*, and α4α6β2* nicotinic acetylcholine receptors (nAChRs; * indicates that…”
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Non-pungent long chain capsaicin-analogs arvanil and olvanil display better anti-invasive activity than capsaicin in human small cell lung cancers by Hurley, John D., Akers, Austin T., Friedman, Jamie R., Nolan, Nicholas A., Brown, Kathleen C., Dasgupta, Piyali

“…The nutritional compound capsaicin inhibits the invasion of many types of human cancers. The clinical development of capsaicin as an anti-cancer drug is…”
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Capsaicinoids enhance chemosensitivity to chemotherapeutic drugs by Friedman, Jamie R, Richbart, Stephen D, Merritt, Justin C, Perry, Haley E, Brown, Kathleen C, Akers, Austin T, Nolan, Nicholas A, Stevenson, Cathryn D, Hurley, John D, Miles, Sarah L, Tirona, Maria T, Valentovic, Monica A, Dasgupta, Piyali

“…Cytotoxic chemotherapy is the mainstay of cancer treatment. Conventional chemotherapeutic agents do not distinguish between normal and neoplastic cells. This…”
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Anti‐invasive and Anti‐metastatic activity of Capsaicin and its natural analogs in Human Lung Adenocarcinoma by Nolan, Nicholas, Akers, Austin, Colclough, Kate, Friedman, Jamie, Brown, Kathleen, Denning, Krista, egleton, Richard, Dasgupta, Piyali

“…Lung cancer is a spectrum of diverse malignancies. In the past several decades, the incidence of lung adenocarcinoma (LAC) has increased greatly and it…”
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N‐AVAM‐Capsaicin Analogs: Potential applications in lung cancer therapy by Dasgupta, Piyali, Gadepalli, Rama, Friedman, Jamie, Akers, Austin, Nolan, Nicholas, Brown, Kathleen, Rimoldi, John

“…The nutritional compound capsaicin is the hot spicy pungent ingredient of chili peppers. Capsaicin is a pain‐relieving agent and is found in several over‐the…”
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Blocking H1/H2 histamine receptors inhibits damage/fibrosis in Mdr2–/– mice and human cholangiocarcinoma tumorigenesis by Kennedy, Lindsey, Hargrove, Laura, Demieville, Jennifer, Karstens, Walker, Jones, Hannah, DeMorrow, Sharon, Meng, Fanyin, Invernizzi, Pietro, Bernuzzi, Francesca, Alpini, Gianfranco, Smith, Steven, Akers, Austin, Meadows, Vik, Francis, Heather

“…Primary sclerosing cholangitis (PSC) patients are at risk of developing cholangiocarcinoma (CCA). We have shown that (1) histamine increases biliary…”
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Effects of nicotine + morphine on reward‐related behavior and nicotinic acetylcholine receptor regulation in mouse midbrain by Avelar, Alicia Jo, Akers, Austin T., Cooper, Skylar Y., Kasireddy, Vishnupriya, Henderson, Brandon J.

“…Abstract only In the United States about 480,000 deaths/year are caused by cigarette smoking and about 50,000 due to opioid abuse. Co‐use of more than one drug…”
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The Synthetic Capsaicin‐analog Arvanil sensitizes Cisplatin‐Resistant Human Lung Cancer Cells to the pro‐apoptotic activity of Irinotecan by Friedman, Jamie, Perry, Haley, Colclough, Kate, Akers, Austin, Nolan, Nicholas, Brown, Kathleen, Chen, Yi Charlie, Dasgupta, Piyali

“…Cisplatin‐based combination therapy is the standard of care for the treatment of human lung cancer. Initially, cisplatin shows excellent therapeutic response…”
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Green Apple Tobacco Flavorant Farnesol Enhances Nicotine Reward‐related Behavior by Avelar, Alicia Jo, Akers, Austin T, Cooper, Skylar Y, Baumgard, Zack J, Henderson, Brandon J

“…Previous investigations have shown that menthol, the most popular tobacco flavor, can enhance nicotine reward and reinforcement. With the growing popularity of…”
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Capsaicin enhances the pro‐apoptotic activity of Camptothecin in human small cell lung cancer by Merritt, Justin, Friedman, Jamie, Perry, Haley, Colclough, Kate, Akers, Austin, Nolan, Nicholas, Brown, Kathleen, Chen, Yi Charlie, Denning, Krista, Dasgupta, Piyali

“…Small cell lung cancer (SCLC) accounts for 20% of all lung cancer cases and has a dismal five‐ year survival rate of less than 5%. Cisplatin‐based combination…”
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