Search Results - "Akerman, Colin J."

Random synaptic feedback weights support error backpropagation for deep learning by Lillicrap, Timothy P., Cownden, Daniel, Tweed, Douglas B., Akerman, Colin J.

“…The brain processes information through multiple layers of neurons. This deep architecture is representationally powerful, but complicates learning because it…”
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Disrupting Epileptiform Activity by Preventing Parvalbumin Interneuron Depolarization Block by Călin, Alexandru, Ilie, Andrei S, Akerman, Colin J

“…Inhibitory synaptic mechanisms oppose epileptic network activity in the brain. The breakdown in this inhibitory restraint and propagation of seizure activity…”
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Excitatory effects of parvalbumin-expressing interneurons maintain hippocampal epileptiform activity via synchronous afterdischarges by Ellender, Tommas J, Raimondo, Joseph V, Irkle, Agnese, Lamsa, Karri P, Akerman, Colin J

“…Epileptic seizures are characterized by periods of hypersynchronous, hyperexcitability within brain networks. Most seizures involve two stages: an initial…”
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A role for the cortex in sleep–wake regulation by Krone, Lukas B., Yamagata, Tomoko, Blanco-Duque, Cristina, Guillaumin, Mathilde C. C., Kahn, Martin C., van der Vinne, Vincent, McKillop, Laura E., Tam, Shu K. E., Peirson, Stuart N., Akerman, Colin J., Hoerder-Suabedissen, Anna, Molnár, Zoltán, Vyazovskiy, Vladyslav V.

“…Cortical and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global state control, respectively. Here we…”
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Ion dynamics during seizures by Raimondo, Joseph V, Burman, Richard J, Katz, Arieh A, Akerman, Colin J

“…Changes in membrane voltage brought about by ion fluxes through voltage and transmitter-gated channels represent the basis of neural activity. As such,…”
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Chloride dynamics alter the input-output properties of neurons by Currin, Christopher B, Trevelyan, Andrew J, Akerman, Colin J, Raimondo, Joseph V

“…Fast synaptic inhibition is a critical determinant of neuronal output, with subcellular targeting of synaptic inhibition able to exert different…”
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All-optical reporting of inhibitory receptor driving force in the nervous system by Selfe, Joshua S., Steyn, Teresa J. S., Shorer, Eran F., Burman, Richard J., Düsterwald, Kira M., Kraitzick, Ariel Z., Abdelfattah, Ahmed S., Schreiter, Eric R., Newey, Sarah E., Akerman, Colin J., Raimondo, Joseph V.

“…Ionic driving forces provide the net electromotive force for ion movement across receptors, channels, and transporters, and are a fundamental property of all…”
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Embryonic progenitor pools generate diversity in fine-scale excitatory cortical subnetworks by Ellender, Tommas J., Avery, Sophie V., Mahfooz, Kashif, Scaber, Jakub, von Klemperer, Alexander, Nixon, Sophie L., Buchan, Matthew J., van Rheede, Joram J., Gatti, Aleksandra, Waites, Cameron, Pavlou, Hania J., Sims, David, Newey, Sarah E., Akerman, Colin J.

“…The mammalian neocortex is characterized by a variety of neuronal cell types and precise arrangements of synaptic connections, but the processes that generate…”
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Calcium-dependent neuroepithelial contractions expel damaged cells from the developing brain by Herrgen, Leah, Voss, Oliver P., Akerman, Colin J.

“…Both developing and adult organisms need efficient strategies for wound repair. In adult mammals, wounding triggers an inflammatory response that can…”
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Pro-maturational Effects of Human iPSC-Derived Cortical Astrocytes upon iPSC-Derived Cortical Neurons by Hedegaard, Anne, Monzón-Sandoval, Jimena, Newey, Sarah E., Whiteley, Emma S., Webber, Caleb, Akerman, Colin J.

“…Astrocytes influence neuronal maturation and function by providing trophic support, regulating the extracellular environment, and modulating signaling at…”
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Refining the roles of GABAergic signaling during neural circuit formation by Akerman, Colin J, Cline, Hollis T

“…Our understanding of the role of GABA signaling in circuit development is rapidly expanding. Here, we review three recent refinements in our understanding of…”
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Effects of clozapine-N-oxide and compound 21 on sleep in laboratory mice by Traut, Janine, Mengual, Jose Prius, Meijer, Elise J, McKillop, Laura E, Alfonsa, Hannah, Hoerder-Suabedissen, Anna, Song, Seo Ho, Fehér, Kristoffer D, Riemann, Dieter, Molnar, Zoltan, Akerman, Colin J, Vyazovskiy, Vladyslav V, Krone, Lukas B

“…Designer receptors exclusively activated by designer drugs (DREADDs) are chemogenetic tools for remote control of targeted cell populations using chemical…”
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sUPRa is a dual-color reporter for unbiased quantification of the unfolded protein response with cellular resolution by Chakrabarty, Atreyi, Newey, Sarah E., Promi, Maisha M., Agbetiameh, Belinda K., Munro, Daniella, Brodersen, Paul J. N., Gothard, Gemma, Mahfooz, Kashif, Mengual, Jose P., Vyazovskiy, Vladyslav V., Akerman, Colin J.

“…The unfolded protein response (UPR) maintains proteostasis upon endoplasmic reticulum (ER) stress, and is initiated by a range of physiological and…”
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Higher-order thalamocortical circuits are specified by embryonic cortical progenitor types in the mouse brain by Buchan, Matthew J., Gothard, Gemma, Mahfooz, Kashif, van Rheede, Joram J., Avery, Sophie V., Vourvoukelis, Alexios, Demby, Alexander, Ellender, Tommas J., Newey, Sarah E., Akerman, Colin J.

“…The sensory cortex receives synaptic inputs from both first-order and higher-order thalamic nuclei. First-order inputs relay simple stimulus properties from…”
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Chemogenetic Recruitment of Specific Interneurons Suppresses Seizure Activity by Cǎlin, Alexandru, Stancu, Mihai, Zagrean, Ana-Maria, Jefferys, John G R, Ilie, Andrei S, Akerman, Colin J

“…Current anti-epileptic medications that boost synaptic inhibition are effective in reducing several types of epileptic seizure activity. Nevertheless, these…”
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Sensory-Evoked Spiking Behavior Emerges via an Experience-Dependent Plasticity Mechanism by van Rheede, Joram J., Richards, Blake A., Akerman, Colin J.

“…The ability to generate action potentials (spikes) in response to synaptic input determines whether a neuron participates in information processing. How a…”
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Biophysical models reveal the relative importance of transporter proteins and impermeant anions in chloride homeostasis by Düsterwald, Kira M, Currin, Christopher B, Burman, Richard J, Akerman, Colin J, Kay, Alan R, Raimondo, Joseph V

“…Fast synaptic inhibition in the nervous system depends on the transmembrane flux of Cl ions based on the neuronal Cl driving force. Established theories…”
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Backpropagation and the brain by Lillicrap, Timothy P., Santoro, Adam, Marris, Luke, Akerman, Colin J., Hinton, Geoffrey

“…During learning, the brain modifies synapses to improve behaviour. In the cortex, synapses are embedded within multilayered networks, making it difficult to…”
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Somnotate: A probabilistic sleep stage classifier for studying vigilance state transitions by Brodersen, Paul J N, Alfonsa, Hannah, Krone, Lukas B, Blanco-Duque, Cristina, Fisk, Angus S, Flaherty, Sarah J, Guillaumin, Mathilde C C, Huang, Yi-Ge, Kahn, Martin C, McKillop, Laura E, Milinski, Linus, Taylor, Lewis, Thomas, Christopher W, Yamagata, Tomoko, Foster, Russell G, Vyazovskiy, Vladyslav V, Akerman, Colin J

“…Electrophysiological recordings from freely behaving animals are a widespread and powerful mode of investigation in sleep research. These recordings generate…”
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The Role of TRESK in Discrete Sensory Neuron Populations and Somatosensory Processing by Weir, Greg A, Pettingill, Philippa, Wu, Yukyee, Duggal, Galbha, Ilie, Andrei-Sorin, Akerman, Colin J, Cader, M Zameel

“…Two-pore domain K (K ) channels generate K leak current, which serves a vital role in controlling and modulating neuronal excitability. This diverse family of…”
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