Search Results - "Akerley, Brian J"

High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism by Griffin, Jennifer E, Gawronski, Jeffrey D, Dejesus, Michael A, Ioerger, Thomas R, Akerley, Brian J, Sassetti, Christopher M

“…The pathways that comprise cellular metabolism are highly interconnected, and alterations in individual enzymes can have far-reaching effects. As a result,…”
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Underlying Glycans Determine the Ability of Sialylated Lipooligosaccharide To Protect Nontypeable Haemophilus influenzae from Serum IgM and Complement by Jackson, Mary Darby, Wong, Sandy M, Akerley, Brian J

“…Nontypeable (NTHi) efficiently colonizes the human nasopharynx asymptomatically but also causes respiratory mucosal infections, including otitis media,…”
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Tracking insertion mutants within libraries by deep sequencing and a genome-wide screen for Haemophilus genes required in the lung by Gawronski, Jeffrey D, Wong, Sandy M.S, Giannoukos, Georgia, Ward, Doyle V, Akerley, Brian J

“…Rapid genome-wide identification of genes required for infection would expedite studies of bacterial pathogens. We developed genome-scale "negative selection"…”
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Genome-wide fitness profiling reveals adaptations required by Haemophilus in coinfection with influenza A virus in the murine lung by Wong, Sandy M., Bernui, Mariana, Shen, Hao, Akerley, Brian J.

“…Bacterial coinfection represents a major cause of morbidity and mortality in epidemics of influenza A virus (IAV). The bacterium Haemophilus influenzae…”
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Outer Membrane Protein P5 Is Required for Resistance of Nontypeable Haemophilus influenzae to Both the Classical and Alternative Complement Pathways by Rosadini, Charles V, Ram, Sanjay, Akerley, Brian J

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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No-Go Zones for Mariner Transposition by Akerley, Brian J

“…The property of transposons to randomly insert into target DNA has long been exploited for generalized mutagenesis and forward genetic screens. Newer…”
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Memory Th17 cell-mediated protection against lethal secondary pneumococcal pneumonia following influenza infection by Li, Yong, Yang, Ying, Chen, Dafan, Wang, Yan, Zhang, Xinyun, Li, Wenchao, Chen, Shengsen, Wong, Sandy M, Shen, Mengwen, Akerley, Brian J, Shen, Hao

“…( ) frequently causes secondary pneumonia after influenza A virus (IAV) infection, leading to high morbidity and mortality worldwide. Concomitant pneumococcal…”
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Suppression of Alternative Lipooligosaccharide Glycosyltransferase Activity by UDP-Galactose Epimerase Enhances Murine Lung Infection and Evasion of Serum IgM by Wong, Sandy M, Jackson, Mary Darby, Akerley, Brian J

“…In pathogens that produce lipooligosaccharide (LOS), sugar residues within the surface-exposed LOS outer core mediate interactions with components of the host…”
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Defining the Binding Region in Factor H to Develop a Therapeutic Factor H-Fc Fusion Protein against Non-Typeable Haemophilus influenzae by Wong, Sandy M, Shaughnessy, Jutamas, Ram, Sanjay, Akerley, Brian J

“…Non-typeable Haemophilus influenzae (NTHi) cause a range of illnesses including otitis media, sinusitis, and exacerbation of chronic obstructive pulmonary…”
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A Novel Zinc Binding System, ZevAB, Is Critical for Survival of Nontypeable Haemophilus influenzae in a Murine Lung Infection Model by ROSADINI, Charles V, GAWRONSKI, Jeffrey D, RAIMUNDA, Daniel, ARGIIELLO, Jose M, AKERLEY, Brian J

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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ArcA regulon and oxidative stress resistance in Haemophilus influenzae by Wong, Sandy M.S, Alugupalli, Kishore R, Ram, Sanjay, Akerley, Brian J

“…Haemophilus influenzae transits between niches within the human host that are predicted to differ in oxygen levels. The ArcAB two-component signal transduction…”
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ArcA-Regulated Glycosyltransferase Lic2B Promotes Complement Evasion and Pathogenesis of Nontypeable Haemophilus influenzae by WONG, Sandy M. S, MICHAEL, Frank St, COX, Andrew, RAM, Sanjay, AKERLEY, Brian J

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Copper Efflux System Required in Murine Lung Infection by Haemophilus influenzae Composed of a Canonical ATPase Gene and Tandem Chaperone Gene Copies by Wong, Sandy M, Gawronski, Jeffrey, Akerley, Brian J

“…Copper is an essential micronutrient but is toxic at high concentrations. In Haemophilus influenzae mechanisms of copper resistance and its role in…”
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Resistance of Haemophilus influenzae to Reactive Nitrogen Donors and Gamma Interferon-Stimulated Macrophages Requires the Formate-Dependent Nitrite Reductase Regulator-Activated ytfE Gene by Harrington, Jane C, Wong, Sandy M.S, Rosadini, Charles V, Garifulin, Oleg, Boyartchuk, Victor, Akerley, Brian J

“…Haemophilus influenzae efficiently colonizes and persists at the human nasopharyngeal mucosa, causing disease when it spreads to other sites. Nitric oxide (NO)…”
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Transposon mutagenesis of Campylobacter jejuni identifies a bipartite energy taxis system required for motility by Hendrixson, David R., Akerley, Brian J., DiRita, Victor J.

“…Campylobacter jejuni constitutes the leading cause of bacterial gastroenteritis in the United States and a major cause of diarrhoea worldwide. Little is known…”
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Sialic Acid Protects Nontypeable Haemophilus influenzae from Natural IgM and Promotes Survival in Murine Respiratory Tract by Jackson, Mary Darby, Wong, Sandy M, Akerley, Brian J

“…Nontypeable (NTHi), a common inhabitant of the human nasopharynx and upper airways, causes opportunistic respiratory tract infections that are frequently…”
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A Transcriptional Activator of Ascorbic Acid Transport in Streptococcus pneumoniae Is Required for Optimal Growth in Endophthalmitis in a Strain-Dependent Manner by Benton, Angela H, Jackson, Mary Darby, Wong, Sandy M, Dees, Justine L, Akerley, Brian J, Marquart, Mary E

“…is among the top causes of bacterial endophthalmitis, an infectious disease of the intraocular fluids. The mechanisms by which grows and thrives in the…”
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In vivo Transposition of mariner-Based Elements in Enteric Bacteria and Mycobacteria by Rubin, Eric J., Akerley, Brian J., Novik, Veronica N., Lampe, David J., Husson, Robert N., Mekalanos, John J.

“…mariner family transposons are widespread among eukaryotic organisms. These transposons are apparently horizontally transmitted among diverse eukaryotes and…”
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Genome-scale approaches to identify genes essential for Haemophilus influenzae pathogenesis by Wong, Sandy M S, Akerley, Brian J

“…Haemophilus influenzae is a Gram-negative bacterium that has no identified natural niche outside of the human host. It primarily colonizes the nasopharyngeal…”
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Systematic Identification of Essential Genes by in vitro mariner Mutagenesis by Akerley, Brian J., Rubin, Eric J., Camilli, Andrew, Lampe, David J., Robertson, Hugh M., Mekalanos, John J.

“…Although the complete DNA sequences of several microbial genomes are now available, nearly 40% of the putative genes lack identifiable functions. Comprehensive…”
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