Search Results - "Akerberg, Brynn N"

A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers by Akerberg, Brynn N., Gu, Fei, VanDusen, Nathan J., Zhang, Xiaoran, Dong, Rui, Li, Kai, Zhang, Bing, Zhou, Bin, Sethi, Isha, Ma, Qing, Wasson, Lauren, Wen, Tong, Liu, Jinhua, Dong, Kunzhe, Conlon, Frank L., Zhou, Jiliang, Yuan, Guo-Cheng, Zhou, Pingzhu, Pu, William T.

“…Mapping the chromatin occupancy of transcription factors (TFs) is a key step in deciphering developmental transcriptional programs. Here we use biotinylated…”
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The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis by Chen, Heidi I, Sharma, Bikram, Akerberg, Brynn N, Numi, Harri J, Kivelä, Riikka, Saharinen, Pipsa, Aghajanian, Haig, McKay, Andrew S, Bogard, Patrick E, Chang, Andrew H, Jacobs, Andrew H, Epstein, Jonathan A, Stankunas, Kryn, Alitalo, Kari, Red-Horse, Kristy

“…Identifying coronary artery progenitors and their developmental pathways could inspire novel regenerative treatments for heart disease. Multiple sources of…”
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Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor by Guo, Yuxuan, Jardin, Blake D., Zhou, Pingzhu, Sethi, Isha, Akerberg, Brynn N., Toepfer, Christopher N, Ai, Yulan, Li, Yifei, Ma, Qing, Guatimosim, Silvia, Hu, Yongwu, Varuzhanyan, Grigor, VanDusen, Nathan J., Zhang, Donghui, Chan, David C., Yuan, Guo-Cheng, Seidman, Christine E., Seidman, Jonathan G., Pu, William T.

“…After birth, cardiomyocytes (CM) acquire numerous adaptations in order to efficiently pump blood throughout an animal’s lifespan. How this maturation process…”
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YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like Receptor Genes by Gao, Yunan, Sun, Yan, Ercan-Sencicek, Adife Gulhan, King, Justin S, Akerberg, Brynn N, Ma, Qing, Kontaridis, Maria I, Pu, William T, Lin, Zhiqiang

“…Toll-like receptors (TLRs) are a family of pattern recognition receptors (PRRs) that modulate innate immune responses and play essential roles in the…”
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Mapping cell type-specific transcriptional enhancers using high affinity, lineage-specific Ep300 bioChIP-seq by Zhou, Pingzhu, Gu, Fei, Zhang, Lina, Akerberg, Brynn N, Ma, Qing, Li, Kai, He, Aibin, Lin, Zhiqiang, Stevens, Sean M, Zhou, Bin, Pu, William T

“…Understanding the mechanisms that regulate cell type-specific transcriptional programs requires developing a lexicon of their genomic regulatory elements. We…”
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Genetic and Epigenetic Control of Heart Development by Akerberg, Brynn N, Pu, William T

“…A transcriptional program implemented by transcription factors and epigenetic regulators governs cardiac development and disease. Mutations in these factors…”
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TEAD1 protects against necroptosis in postmitotic cardiomyocytes through regulation of nuclear DNA-encoded mitochondrial genes by Liu, Jinhua, Wen, Tong, Dong, Kunzhe, He, Xiangqin, Zhou, Hongyi, Shen, Jian, Fu, Zurong, Hu, Guoqing, Ma, Wenxia, Li, Jie, Wang, Wenjuan, Wang, Liang, Akerberg, Brynn N., Xu, Jiqian, Osman, Islam, Zheng, Zeqi, Wang, Wang, Du, Quansheng, Pu, William T., Xiang, Meixiang, Chen, Weiqin, Su, Huabo, Zhang, Wei, Zhou, Jiliang

“…The Hippo signaling effector, TEAD1 plays an essential role in cardiovascular development. However, a role for TEAD1 in postmitotic cardiomyocytes (CMs)…”
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In Vivo Dissection of Chamber-Selective Enhancers Reveals Estrogen-Related Receptor as a Regulator of Ventricular Cardiomyocyte Identity by Cao, Yangpo, Zhang, Xiaoran, Akerberg, Brynn N., Yuan, Haiyun, Sakamoto, Tomoya, Xiao, Feng, VanDusen, Nathan J., Zhou, Pingzhu, Sweat, Mason E., Wang, Yi, Prondzynski, Maksymilian, Chen, Jian, Zhang, Yan, Wang, Peizhe, Kelly, Daniel P., Pu, William T.

“…Cardiac chamber-selective transcriptional programs underpin the structural and functional differences between atrial and ventricular cardiomyocytes (aCMs and…”
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Endocardial Brg1 disruption illustrates the developmental origins of semilunar valve disease by Akerberg, Brynn N., Sarangam, Maithri L., Stankunas, Kryn

“…The formation of intricately organized aortic and pulmonic valves from primitive endocardial cushions of the outflow tract is a remarkable accomplishment of…”
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Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease by Kathiriya, Irfan S., Rao, Kavitha S., Iacono, Giovanni, Devine, W. Patrick, Blair, Andrew P., Hota, Swetansu K., Lai, Michael H., Garay, Bayardo I., Thomas, Reuben, Gong, Henry Z., Wasson, Lauren K., Goyal, Piyush, Sukonnik, Tatyana, Hu, Kevin M., Akgun, Gunes A., Bernard, Laure D., Akerberg, Brynn N., Gu, Fei, Li, Kai, Speir, Matthew L., Haeussler, Maximilian, Pu, William T., Stuart, Joshua M., Seidman, Christine E., Seidman, J.G., Heyn, Holger, Bruneau, Benoit G.

“…Haploinsufficiency of transcriptional regulators causes human congenital heart disease (CHD); however, the underlying CHD gene regulatory network (GRN)…”
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GATA4 Regulates Developing Endocardium Through Interaction With ETS1 by Zhou, Pingzhu, Zhang, Yan, Sethi, Isha, Ye, Lincai, Trembley, Michael A., Cao, Yangpo, Akerberg, Brynn N., Xiao, Feng, Zhang, Xiaoran, Li, Kai, Jardin, Blake D., Mazumdar, Neil, Ma, Qing, He, Aibin, Zhou, Bin, Pu, William T.

“…The pioneer transcription factor (TF) GATA4 (GATA Binding Protein 4) is expressed in multiple cardiovascular lineages and is essential for heart development…”
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CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene programs in the developing heart by Robbe, Zachary L, Shi, Wei, Wasson, Lauren K, Scialdone, Angel P, Wilczewski, Caralynn M, Sheng, Xinlei, Hepperla, Austin J, Akerberg, Brynn N, Pu, William T, Cristea, Ileana M, Davis, Ian J, Conlon, Frank L

“…The nucleosome remodeling and deacetylase (NuRD) complex is one of the central chromatin remodeling complexes that mediates gene repression. NuRD is essential…”
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In Vivo Dissection of Chamber-Selective Enhancers Reveals Estrogen-Related Receptor as a Regulator of Ventricular Cardiomyocyte Identity by Cao, Yangpo, Zhang, Xiaoran, Akerberg, Brynn N., Yuan, Haiyun, Sakamoto, Tomoya, Xiao, Feng, VanDusen, Nathan J., Zhou, Pingzhu, Sweat, Mason E., Wang, Yi, Prondzynski, Maksymilian, Chen, Jian, Zhang, Yan, Wang, Peizhe, Kelly, Daniel P., Pu, William T.

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