Search Results - "Akella, Lakshmi"

A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion by Kopp, Felix, Stratton, Christopher F, Akella, Lakshmi B, Tan, Derek S

“…Macrocycles are well represented in natural product structures but have been challenging to access for inclusion in synthetic libraries. A new method uses ring…”
Get full text

Cheminformatics approaches to analyze diversity in compound screening libraries by Akella, Lakshmi B, DeCaprio, David

“…As high-throughput screening matures as a discipline, cheminformatics is playing an increasingly important role in selecting new compounds for diverse…”
Get full text

NetiNeti: discovery of scientific names from text using machine learning methods by Akella, Lakshmi Manohar, Norton, Catherine N, Miller, Holly

“…A scientific name for an organism can be associated with almost all biological data. Name identification is an important step in many text mining tasks aiming…”
Get full text

Fragment-based domain shuffling approach for the synthesis of pyran-based macrocycles by Comer, Eamon, Liu, Haibo, Joliton, Adrien, Clabaut, Alexandre, Johnson, Christopher, Akella, Lakshmi B., Marcaurelle, Lisa A., Schreiber, Stuart L.

“…Complexity and the presence of stereogenic centers have been correlated with success as compounds transition from discovery through the clinic. Here we…”
Get full text

Application of a Catalytic Asymmetric Povarov Reaction using Chiral Ureas to the Synthesis of a Tetrahydroquinoline Library by Gerard, Baudouin, O’Shea, Morgan Welzel, Donckele, Etienne, Kesavan, Sarathy, Akella, Lakshmi B, Xu, Hao, Jacobsen, Eric N, Marcaurelle, Lisa A

“…A 2328-membered library of 2,3,4-trisubstituted tetrahydroquinolines was produced using a combination of solution- and solid-phase synthesis techniques. A…”
Get full text

Application of a Sparse Matrix Design Strategy to the Synthesis of DOS Libraries by Akella, Lakshmi B, Marcaurelle, Lisa A

“…We have implemented an interactive and practical sparse matrix design strategy for the synthesis of DOS libraries, which facilitates the selection of diverse…”
Get full text

Build/Couple/Pair Strategy for the Synthesis of Stereochemically Diverse Macrolactams via Head-to-Tail Cyclization by Fitzgerald, Mark E, Mulrooney, Carol A, Duvall, Jeremy R, Wei, Jingqiang, Suh, Byung-Chul, Akella, Lakshmi B, Vrcic, Anita, Marcaurelle, Lisa A

“…A build/couple/pair (B/C/P) strategy was employed to generate a library of 7936 stereochemically diverse 12-membered macrolactams. All 8 stereoisomers of a…”
Get full text

Synthesis of a Stereochemically Diverse Library of Medium-Sized Lactams and Sultams via SNAr Cycloetherification by Gerard, Baudouin, Duvall, Jeremy R, Lowe, Jason T, Murillo, Tiffanie, Wei, Jingqiang, Akella, Lakshmi B, Marcaurelle, Lisa A

“…We have implemented an aldol-based “build/couple/pair” (B/C/P) strategy for the synthesis of stereochemically diverse 8-membered lactam and sultam scaffolds…”
Get full text

Synthesis of Stereochemically and Skeletally Diverse Fused Ring Systems from Functionalized C‑Glycosides by Gerard, Baudouin, Lee, Maurice D, Dandapani, Sivaraman, Duvall, Jeremy R, Fitzgerald, Mark E, Kesavan, Sarathy, Lowe, Jason T, Marié, Jean-Charles, Pandya, Bhaumik A, Suh, Byung-Chul, O’Shea, Morgan Welzel, Dombrowski, Michael, Hamann, Diane, Lemercier, Berenice, Murillo, Tiffanie, Akella, Lakshmi B, Foley, Michael A, Marcaurelle, Lisa A

“…A diversity-oriented synthesis (DOS) strategy was developed for the synthesis of stereochemically diverse fused-ring systems containing a pyran moiety. Each…”
Get full text

An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors by Marcaurelle, Lisa A, Comer, Eamon, Dandapani, Sivaraman, Duvall, Jeremy R, Gerard, Baudouin, Kesavan, Sarathy, Lee, Maurice D, Liu, Haibo, Lowe, Jason T, Marie, Jean-Charles, Mulrooney, Carol A, Pandya, Bhaumik A, Rowley, Ann, Ryba, Troy D, Suh, Byung-Chul, Wei, Jingqiang, Young, Damian W, Akella, Lakshmi B, Ross, Nathan T, Zhang, Yan-Ling, Fass, Daniel M, Reis, Surya A, Zhao, Wen-Ning, Haggarty, Stephen J, Palmer, Michelle, Foley, Michael A

“…An aldol-based build/couple/pair (B/C/P) strategy was applied to generate a collection of stereochemically and skeletally diverse small molecules. In the build…”
Get full text

Synthesis and Profiling of a Diverse Collection of Azetidine-Based Scaffolds for the Development of CNS-Focused Lead-like Libraries by Lowe, Jason T, Lee, Maurice D, Akella, Lakshmi B, Davoine, Emeline, Donckele, Etienne J, Durak, Landon, Duvall, Jeremy R, Gerard, Baudouin, Holson, Edward B, Joliton, Adrien, Kesavan, Sarathy, Lemercier, Berenice C, Liu, Haibo, Marié, Jean-Charles, Mulrooney, Carol A, Muncipinto, Giovanni, Welzel-O’Shea, Morgan, Panko, Laura M, Rowley, Ann, Suh, Byung-Chul, Thomas, Meryl, Wagner, Florence F, Wei, Jingqiang, Foley, Michael A, Marcaurelle, Lisa A

“…The synthesis and diversification of a densely functionalized azetidine ring system to gain access to a wide variety of fused, bridged, and spirocyclic ring…”
Get full text

Correction to Application of a Catalytic Asymmetric Povarov Reaction using Chiral Ureas to the Synthesis of a Tetrahydroquinoline Library by Gerard, Baudouin, O’Shea, Morgan Welzel, Donckele, Etienne, Kesavan, Sarathy, Akella, Lakshmi B, Xu, Hao, Jacobsen, Eric N, Marcaurelle, Lisa A

Get full text

An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries by Mulrooney, Carol A., Lahr, David L., Quintin, Michael J., Youngsaye, Willmen, Moccia, Dennis, Asiedu, Jacob K., Mulligan, Evan L., Akella, Lakshmi B., Marcaurelle, Lisa A., Montgomery, Philip, Bittker, Joshua A., Clemons, Paul A., Brudz, Stephen, Dandapani, Sivaraman, Duvall, Jeremy R., Tolliday, Nicola J., De Souza, Andrea

“…Integration of flexible data-analysis tools with cheminformatics methods is a prerequisite for successful identification and validation of “hits” in…”
Get full text

Structural Unit Analysis Identifies Lead Series and Facilitates Scaffold Hopping in Combinatorial Chemistry by Wolohan, Philippa R. N, Akella, Lakshmi B, Dorfman, Roman J, Nell, Peter G, Mundt, Stefan M, Clark, Robert D

“…Combinatorial chemistry and high-throughput screening technologies produce huge amounts of data on a regular basis. Sieving through these libraries of…”
Get full text

High-throughput single particle tracking reveals estrogen receptor protein interaction landscape in living cells by McSwiggen, David, Liu, Helen, Chen, Hanzhe, Heckert, Alec, Ho, Jaclyn, Johnson, Stephanie L., Akella, Lakshmi, Gonzalez, Eric, Hanuka, Adi, Li, Yan, Sule, Akshay, Pierce, Sarah, Tan, Ruensern, Beck, Hilary, Anderson, Daniel

Get full text

An advanced deep learning method to detect and classify diabetic retinopathy based on color fundus images by Akella, Prasanna Lakshmi, Kumar, R.

“…Background In this article, we present a computerized system for the analysis and assessment of diabetic retinopathy (DR) based on retinal fundus photographs…”
Get full text

SeMoP: A New Computational Strategy for the Unrestricted Search for Modified Peptides Using LC−MS/MS Data by Baumgartner, Christian, Rejtar, Tomas, Kullolli, Majlinda, Akella, Lakshmi Manohar, Karger, Barry L

“…A novel computational approach, termed Search for Modified Peptides (SeMoP), for the unrestricted discovery and verification of peptide modifications in…”
Get full text

Fragment-based domain shuffling approach for the synthesis of pyranbased macrocycles by Comer, Eamon, Liu, Haibo, Joliton, Adrien, Clabaut, Alexandre, Johnson, Christopher, Akella, Lakshmi B, Marcaurelle, Lisa A

“…Complexity and the presence of stereogenic centers have been correlated with success as compounds transition from discovery through the clinic. Here we…”
Get full text

CLUE-TIPS, Clustering Methods for Pattern Analysis of LC−MS Data by Akella, Lakshmi Manohar, Rejtar, Tomas, Orazine, Christina, Hincapie, Marina, Hancock, William S

“…Liquid Chromatography Mass Spectrometry (LC−MS) based proteomics is an important tool in detecting changes in peptide/protein abundances in samples potentially…”
Get full text

Application of a Catalytic Asymmetric Povarov Reaction using Chiral Ureas to the Synthesis of a Tetrahyroquinoline Library by Gerard, Baudouin, O’Shea, Morgan Welzel, Donckele, Etienne, Kesavan, Sarathy, Akella, Lakshmi B., Xu, Hao, Jacobsen, Eric N., Marcaurelle, Lisa A.

“…A 2328-membered library of 2,3,4-trisubstituted tetrahydroquinolines was produced using a combination of solution- and solid-phase synthesis techniques. A…”
Get full text