Impact of the indexed effective orifice area on mid-term cardiac-related mortality after aortic valve replacement

There has been ongoing controversy as to whether prosthesis-patient mismatch (PPM, defined as indexed effective orifice area (EOAI) <0.85 m(2)/cm(2)) influences mortality after aortic valve replacement (AVR). In most studies, PPM is anticipated by reference tables based on mean EOAs as opposed to...

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Bibliographic Details
Published in:	Heart (British Cardiac Society) Vol. 96; no. 11; p. 865
Main Authors:	Bleiziffer, Sabine, Ali, Ayyaz, Hettich, Ina M, Akdere, Deniz, Laubender, Rüdiger P, Ruzicka, Daniel, Boehm, Johannes, Lange, Rüdiger, Eichinger, Walter
Format:	Journal Article
Language:	English
Published:	England 01-06-2010
Subjects:	Aged Aortic Valve - diagnostic imaging Aortic Valve - surgery Aortic Valve Stenosis - diagnostic imaging Aortic Valve Stenosis - mortality Aortic Valve Stenosis - surgery Body Size Epidemiologic Methods Female Heart Valve Prosthesis Heart Valve Prosthesis Implantation - adverse effects Heart Valve Prosthesis Implantation - mortality Humans Male Prosthesis Fitting - mortality Ultrasonography
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Summary:	There has been ongoing controversy as to whether prosthesis-patient mismatch (PPM, defined as indexed effective orifice area (EOAI) <0.85 m(2)/cm(2)) influences mortality after aortic valve replacement (AVR). In most studies, PPM is anticipated by reference tables based on mean EOAs as opposed to individual assessment. These reference values may not reflect the actual in vivo EOAI and hence, the presence or absence of PPM may be based on false assumptions. To assess the impact of small prosthesis EOA on survival after aortic valve replacement AVR. 645 patients had undergone an AVR between 2000 and 2007 entered the study. All patients underwent transthoracic echocardiography for determination of the actual EOAI within 6 months postoperatively. In order to predict time from surgery to death a proportional hazards model for competing risks (cardiac death vs death from other causes) was used. EOAI was entered as a continuous variable. PPM occurred in 40% of the patients. After a median follow-up of 2.35 years, 92.1% of the patients were alive. The final Cox regression model showed a significantly increased risk for cardiac death among patients with a smaller EOAI (HR=0.32, p=0.022). The effect of EOAI on the 2-5 year mortality risk was demonstrated by risk plots. In contrast to previous studies these EOAI values were obtained through postoperative echocardiography, substantially improving the accuracy of measurement, and the EOAI was modelled as a continuous variable. There was a significantly improved survival for larger EOAIs following AVR. Strategies to avoid PPM should become paramount during AVR.
ISSN:	1468-201X
DOI:	10.1136/hrt.2009.177220